CZ415
- CAS No.
- 1429639-50-8
- Chemical Name:
- CZ415
- Synonyms
- CZ415;CS-2392;CZ 415;CZ-415;CZ415 (Free base);inhibit,Inhibitor,mTOR,CZ415,CZ-415,CZ 415,Mammalian target of Rapamycin;(S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea;Urea, N-[4-[5,7-dihydro-7,7-dimethyl-4-[(3S)-3-methyl-4-morpholinyl]-6,6-dioxidothieno[3,4-d]pyrimidin-2-yl]phenyl]-N'-ethyl-
- CBNumber:
- CB83146695
- Molecular Formula:
- C22H29N5O4S
- Molecular Weight:
- 459.56
- MDL Number:
- MFCD30533321
- MOL File:
- 1429639-50-8.mol
| Boiling point | 611.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.287±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:73.67(Max Conc. mg/mL);160.3(Max Conc. mM) DMSO:PBS (pH 7.2) (1:6):0.1(Max Conc. mg/mL);0.22(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);65.28(Max Conc. mM) Ethanol:10.0(Max Conc. mg/mL);21.76(Max Conc. mM) |
| form | A crystalline solid |
| pka | 13.79±0.46(Predicted) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H335-H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| NFPA 704 |
|
CZ415 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27668 | CZ415 | 1429639-50-8 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 27668 | CZ415 | 1429639-50-8 | 25mg | $586 | 2024-03-01 | Buy |
| Cayman Chemical | 27668 | CZ415 | 1429639-50-8 | 5mg | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 27668 | CZ415 | 1429639-50-8 | 10mg | $321 | 2024-03-01 | Buy |
| TRC | C998985 | CZ415 | 1429639-50-8 | 2.5mg | $210 | 2021-12-16 | Buy |
CZ415 Chemical Properties,Uses,Production
Description
CZ415 is an inhibitor of mammalian target of rapamycin (mTOR; Kd = 6.3 nM). It is 1,000-fold selective for mTOR over a panel of 285 kinases. CZ415 inhibits phosphorylation of S6 ribosomal protein (S6RP) and Akt in HEK293T cells (IC50s = 14.5 and 14.8 nM, respectively). It inhibits IFN-γ secretion in IL-2, anti-CD3, and anti-CD28 antibody-stimulated human whole blood (IC50 = 226 nM). CZ415 (10 mg/kg) reduces fore paw joint erythema and swelling in a mouse model of collagen-induced arthritis. It also inhibits intratumor mTOR activity and reduces tumor growth in an OCC-1 oral cavity carcinoma mouse xenograft model when administered at a dose of 20 mg/kg.
Uses
CZ415 is a selective and potent ATP-competitive mTOR inhibitor (1). It demonstrated in vivo efficacy in a semitherapeutic collagen induced arthritis (CIA) mouse model.
CZ415 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |