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UR-PI376
- CAS No.
- 1192559-94-6
- Chemical Name:
- UR-PI376
- Synonyms
- UR-PI376;URPI376,UR PI376;Guanidine, N-cyano-N''-[4-(1H-imidazol-5-yl)butyl]-N'-[2-(phenylthio)ethyl]-
- CBNumber:
- CB83304420
- Molecular Formula:
- C17H22N6S
- Molecular Weight:
- 342.46
- MDL Number:
- MOL File:
- 1192559-94-6.mol
Last updated:2023-03-31 09:12:58
UR-PI376 Chemical Properties,Uses,Production
Description
UR-PI376 is a histamine H4 receptor agonist ( hH4R agonist) (pEC50 = 7.47, alpha = 0.93) showing negligible hH1R and hH2R activities and significant selectivity over the hH3R (pKB = 6.00, alpha = -0.28), as determined in steady-state GTPase assays using membrane preparations of hH(x)R-expressing Sf9 cells. Modeling of the binding mode of UR-PI376 suggests that the cyanoguanidine moiety forms charge-assisted hydrogen bonds not only with the conserved Asp-94 but also with the hH4R-specific Arg-341 residue.
UR-PI376 Preparation Products And Raw materials
Raw materials
Preparation Products
UR-PI376 Suppliers
Global( 2)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
UR-PI376
URPI376,UR PI376
Guanidine, N-cyano-N''-[4-(1H-imidazol-5-yl)butyl]-N'-[2-(phenylthio)ethyl]-
1192559-94-6