Famoxadone | 131807-57-3

Famoxadone Properties

Melting point	140.3～141.8℃
Boiling point	491.3±55.0 °C(Predicted)
Density	1.327±0.06 g/cm3(Predicted)
vapor pressure	6.4 x 10^-7 Pa (20 °C)
Flash point	2 °C
storage temp.	0-6°C
solubility	DMSO: 100 mg/mL (267.10 mM)
pka	0.63±0.40(Predicted)
form	Solid:particulate/powder
Water Solubility	0.243 mg^-1 (pH 5), 0.011 mg l^-1 (pH 7) at 20 °C
LogP	4.65-5.08 at 20℃ and pH4-7
Surface tension	73mN/m at 90μg/L and 20.4℃
EWG's Food Scores	1
FDA UNII	V1C07OR6II
EPA Substance Registry System	Famoxadone (131807-57-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS02,GHS07
Signal word	Danger
Hazard statements	H225-H302-H312-H319-H332
Precautionary statements	P210-P280-P305+P351+P338
Hazard Codes	Xn,N,F
Risk Statements	48/22-50/53-36-20/21/22-11
Safety Statements	46-60-61-36-26-16-36/37
RIDADR	UN1648 3/PG 2
WGK Germany	2
Toxicity	LD50 in rats (mg/kg): >5000 orally; >2000 dermally (Joshi, Sternberg)

Famoxadone price More Price(8)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	33495	Famoxadone solution 100?μg/mL in acetonitrile, PESTANAL?, analytical standard	131807-57-3	2ML	$86.2	2024-03-01	Buy
TRC	F102300	Famoxadone	131807-57-3	1g	$145	2021-12-16	Buy
TRC	F102300	Famoxadone	131807-57-3	10g	$305	2021-12-16	Buy
Medical Isotopes, Inc.	51328	Famoxadone	131807-57-3	1g	$620	2021-12-16	Buy
Medical Isotopes, Inc.	51328	Famoxadone	131807-57-3	50g	$875	2021-12-16	Buy

Product number	Packaging	Price	Buy
33495	2ML	$86.2	Buy
F102300	1g	$145	Buy
F102300	10g	$305	Buy
51328	1g	$620	Buy
51328	50g	$875	Buy

Famoxadone Chemical Properties,Uses,Production

Description

Famoxadone is an oxazolidinedione fungicide. Although famoxadone is not a strobilurin derivative, it shares the same mechanism of action. Famoxadone provides control of a broad spectrum of fungi but is particularly effective against downy mildew (P. viticola), late and early blights (Phytophthora infestans and Alternaria solani), the Septoria complex, and barley net blotch at rates of 50 to 200 g ai/ha. Target crops include vines, potatoes/tomatoes, cereals, sugar beets, canola, and cucumber. It shows good protectant, translaminar and residual control, with excellent rainfastness and good crop safety. As was seen for trifloxystrobin, it is particularly effective against grape downy mildew when applied in mixture with cymoxanil. The cereal disease spectrum and level of disease control are improved when famoxadone is mixed with triazole fungicides such as flusilazole.

Chemical Properties

Brown Solid

Uses

Famoxadone provides preventive control of a broad spectrum of fungal pathogens such as Plasmopara viticola (grape downy mildew), Phytophthora infestans (potato/ tomato late blight), Pseudoperonospora cubensis (cucumber downy mildew), Septoria tritici (wheat leaf blotch), S. nodorum (wheat glume blotch) and Alternaria solani (potato/tomato early blight).

Uses

Agricultural fungicide.

Uses

Famoxadone is a known fungicide used in the protection of agricultural products against various fungal diseases and other biotic stresses such as pests.

Definition

ChEBI: 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-1,3-oxazolidine-2,4-dione is a member of the class of oxazolidinones that is 1,3-oxazolidine-2,4-dione in which the hydrogen attached to the nitrogen is substituted by a phenylamino group and the hydrogens at position 5 are substituted by methyl and 4-phenoxyphenyl groups. It is an aromatic ether, a carbohydrazide and an oxazolidinone.

Agricultural Uses

Fungicide: Tanos 50-DF is recommended for use as a preventative fungicide for control of late blight and early blight on potatoes and field tomatoes.

Trade name

DPX-JE874®; FAMOXATE®; MEDLEY®; TANOS-50DF®

Pharmacology

Famoxadone inhibits activity of ubiquinol : cytochrome c oxidoreductase at the Qo site of complex III, the same target protein as the strobilurins (34,35). However, studies show a difference in the potency of various strobilurins compared with famoxadone in single amino acid mutants of the cytochrome b protein, suggesting that this compound may interact differently with the target protein (38).

Metabolic pathway

Famoxadone undergoes extensive degradation and metabolism in aqueous and soil environments, in wheat plants, rats, goats and hens via common pathways. The primary reactions include the hydrolytic opening of the oxazolidinedione ring, aryl hydroxylation, cleavage of the phenoxyphenyl and the oxazolidinedione-aminophenyl linkages and conjugation. More than 25 degradation products have been identified.

Degradation

Famoxadone is relatively stable to hydrolytic degradation under dark conditions in pH 5 buffer solution (DT₅₀ 41 days) (Jernberg et al., 1998a). It was hydrolysed rapidly at pH 7 and pH 9 at 25 °C (DT₅₀ values 2 days and <2 hours, respectively). No sigruficant sunlight-induced degradation was observed at pH 7. Hydrolytic degradation was catalysed in acidic conditions (pH 5) under natural sunlight (DT₅₀ 4.6 days in contrast to 41 days at pH 7). Primary hydrolytic degradation reactions include the opening of the oxazolidinedione ring [to yieldα-hydroxy-α-methyl-4-phenoxyphenylacetic acid 2-phenylhydrazide (2) and 1-carboxy-1-(4-phenoxy-phenyl) ethyl-2-phenylhydrazinecarboxylic acid (3)], and the cleavage of the oxazolidine-aminophenyl linkage to yield various products from both the phenoxyphenyl moiety [ 1-(4-phenoxyphenyl)ethanone (4) and α-hydroxy- α-methyl-4-phenoxyphenylacetiac acid (5)] and the aminophenyl moiety [small amounts of phenol (6), catechol (7) and benzene (8) via the proposed 2-phenylhydrazinecarboxylic acid intermediate (9)] (see Scheme 1).

Toxicity evaluation

Famoxadone has an acute oral LD₅₀ > 5,000 mg/kg and an acute percutaneous LD₅₀ > 2,000 mg/kg in rats. It is not a skin or eye irritant, is negative in the Ames test, and is nonteratogenic. It shows very little soil degradation, is nonmobile, and has a good ecotoxicological profile.

Famoxadone Preparation Products And Raw materials

Raw materials

3-METHOXYPROPIONIC ACID 4'-Phenoxyacetophenone

Preparation Products

Famoxadone Suppliers

Global( 162)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2141	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Longyan Tianhua Biological Technology Co., Ltd	0086 18039857276 18039857276		CHINA	2783	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Hubei Jusheng Technology Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Longyan Tianhua Biological Technology Co., Ltd	58

View Lastest Price from Famoxadone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2022-10-18	Famoxadone 131807-57-3	US $9.90 / kg	1kg	99%	1000kg	Hebei Duling International Trade Co. LTD
2021-07-13	Famoxadone 131807-57-3	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	Famoxadone 131807-57-3	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Famoxadone
131807-57-3
US $9.90 / kg
99%
Hebei Duling International Trade Co. LTD

Famoxadone
131807-57-3
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Famoxadone
131807-57-3
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

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Isoxazole Methyl Actidione

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3-anilino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-2,4-oxazolidinedione Famoxate Semicarbacide Hydrochloride, Vetranal famoxadone (bsi, pa iso) famoxadone solution Famoxadon Famoxadone 100mg [131807-57-3] famoxadone 3-anilino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione 3-pheny-lamino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione CCharisma DPX-JE 874 IN-JE 874 JE 874 FaMoxadone solutio 2,4-Oxazolidinedione,5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)- FAMOXADONE 3-ANILINO-5-METHYL-5-(4-PHENOXYPHENYL)OXAZOLIDINE-2,4-DIONE 5-Methyl-5-(4-phenoxyphenyl)-3-(phenylamino)oxazolidine-2,4-dione Famoxadone Solution, 1000ppm FamoxadoneSolution,100mg/L,1ml Famoxadone Reference Material Famoxadon@1000 μg/mL in Acetonitrile Famoxadon @100 μg/mL in Acetonitrile Famoxadone Solution in Methanol, 100μg/mL Fensulfothion Impurity 8 Famoxadone Solution in Methanol 131807-57-3 13180-57-3 API agrochemical Fungicide