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Histrelin

Histrelin structure

CAS No.: 76712-82-8

Chemical Name:: Histrelin

Synonyms: histrelin acetate;PYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET;1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)-;N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)-1-pyrrolidinyl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-[1-(phenylmethyl)-4-imidazoly;orf17070;Supprelin;RWJ-17070;HISTRELIN;Amyridine;Histreline Acetate

CBNumber:: CB8480046

Molecular Formula:: C66H86N18O12

Molecular Weight:: 1323.53

MDL Number:: MFCD00133494

MOL File:: 76712-82-8.mol

Last updated:2023-11-16 17:07:08

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Histrelin Properties

alpha	D20 -33.9° (c = 1 in acetic acid)
Density	1.46±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
form	powder
pka	9.82±0.15(Predicted)
Stability	Hygroscopic
NCI Dictionary of Cancer Terms	histrelin acetate
FDA UNII	H50H3S3W74
NCI Drug Dictionary	histrelin acetate
ATC code	L02AE05
Proposition 65 List	Histrelin Acetate

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H360
Precautionary statements	P201-P308+P313
Hazard Codes	T
Risk Statements	60
Safety Statements	53-22-36/37/39-45
WGK Germany	3
RTECS	OK6370800
HS Code	3504009000

Histrelin price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	L2761	[des-Gly10, D-His(Bzl)6]-LH-RH ethylamide ≥97% (HPLC), powder	76712-82-8	0.5mg	$158	2024-03-01	Buy
Sigma-Aldrich	L2761	[des-Gly10, D-His(Bzl)6]-LH-RH ethylamide ≥97% (HPLC), powder	76712-82-8	1mg	$271	2024-03-01	Buy
American Custom Chemicals Corporation	API0002921	HISTRELIN 95.00%	76712-82-8	1MG	$645.9	2021-12-16	Buy
Biorbyt Ltd	orb372383	Histrelin Acetate > 95%	76712-82-8	1mg	$691.9	2021-12-16	Buy
Apolloscientific	BITH3026	Histrelin	76712-82-8	25mg	$719	2021-12-16	Buy

Product number	Packaging	Price	Buy
L2761	0.5mg	$158	Buy
L2761	1mg	$271	Buy
API0002921	1MG	$645.9	Buy
orb372383	1mg	$691.9	Buy
BITH3026	25mg	$719	Buy

Histrelin Chemical Properties,Uses,Production

Description

Histrelin, a synthetic gonadotrophin-releasing hormone (GnRH) agonist, was introduced as a first-line therapy for the treatment of central precocious puberty. When administered over a prolonged period, it suppresses the release of gonadotrophin, inhibits ovarian and testicular steroidogenesis, and prevents sexual maturation. Superior to the traditional therapy with progestational agents, histrelin appears to have decelerating effects on skeletal maturation allowing more statural growth and significantly increased final adult height. Histrelin has also been used to treat other disorders including endometriosis, polycystic ovarian disease, uterine leiomyomas, severe premenstrual syndrome and to prevent acute intermittent porphyria.

Originator

Johnson & Johnson (U.S.A.)

Uses

[des-Gly¹⁰, D-His(Bzl)⁶]-LH-RH ethylamide has been used:

for inducing Batrachoseps gravid females to oviposit
for comparing the effect of LHRH (luteinizing hormone-releasing hormone) agonists and dopamine antagonists in Lithobates pipiens
for inducing oviposition in females of Taricha granulosa and Ensatina eschscoltzii
to induce spawning in Spea hammondii adults

Uses

LHRH agonist.

Definition

ChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, 1-benzyl-D-histidyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotro in-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the diacetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.

brand name

Supprelin (Roberts Pharmaceutical).

Biochem/physiol Actions

Glp-His-Trp-Ser-Tyr-His(Bzl)-Leu-Arg-Pro-NHEt ([des-Gly10, D-His(Bzl)6]-LH-RH) is a GnRH (gonadotropin-releasing hormone) agonist, histerelin. GnRH (Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism. Histerelin is used for the treatment of central precocious puberty in children. It inhibits actions of sex steroids on the male and female reproductive organs.

Histrelin Preparation Products And Raw materials

Raw materials

Preparation Products

Histrelin Suppliers

Global( 144)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	Cecilia@youngshechem.com	China	2345	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	616	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	999	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10297	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58

Supplier	Advantage
Chengdu Youngshe Chemical Co., Ltd.	58
Nantong Guangyuan Chemicl Co,Ltd	58
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Cellmano Biotech Limited	58
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58
Hebei Mojin Biotechnology Co., Ltd	58

View Lastest Price from Histrelin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-03-08	Histrelin 76712-82-8	US $10.00 / kg	1kg	99%	1000kg	Nantong Guangyuan Chemicl Co,Ltd
2023-05-20	Histrelin 76712-82-8	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2023-01-13	Histrelin Acetate 76712-82-8	US $0.00 / g	1g	98%min	1000g	WUHAN FORTUNA CHEMICAL CO., LTD

Histrelin
76712-82-8
US $10.00 / kg
99%
Nantong Guangyuan Chemicl Co,Ltd

Histrelin
76712-82-8
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

Histrelin Acetate
76712-82-8
US $0.00 / g
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

76712-82-8(Histrelin)Related Search:

Benzyl acetate Butyl acetate Cellulose acetate Ammonium acetate Magnesium acetate

Goserelin acetate Vinyl acetate Sodium acetate Taltirelin Alarelin Acetate

Ethyl acetate LHRH (1-6) AMIDE FERTIRELIN ACETATE Histamine

L-Prolinamide (D-LEU7)-HISTRELIN Fertirelin acetate

1of4

Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt 5-oxo-L-pmlyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N^^-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-pmlinamide RWJ-17070 Supprelin 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-1-benzyl-D-His-L-Leu-L-Arg-L-Pro-N-ethyl-NH2 Histreline Acetate ((imbl)-d-his(sub6),pro(sub9)-net)lhrh (n-ethyl-l-prolinamide)-10-deglycinamide- 6-(1-(phenylmethyl)-d-histidine)-9-luteinizinghormonereleasingfactor(pig orf17070 PYR-HIS-TRP-SER-TYR-HIS(BZL)-LEU-ARG-PRO-NHET PGLU-HIS-TRP-SER-TYR-D-HIS[BZL]-LEU-ARG-PRO-NHET (HIS(BZL)6)-HISTRELIN HISTRELIN (DES-GLY10,HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LHRH (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE DES-GLY10,[D-HIS(BZL)6]-LH-RH ETHYLAMIDE (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LHRH [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LH-RH (HUMAN) (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE (HUMAN) Histrelin USP/EP/BP Histrelin Acetate(net) 1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)- PYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET histrelin acetate N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)-1-pyrrolidinyl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-[1-(phenylmethyl)-4-imidazoly Amyridine 76712-82-8 C66H86N18O12 Biochemicals and Reagents Amino Acids and Peptides BioChemical Peptides Releasing Factors LH-RH hormones Peptide