Tizanidine hydrochloride
- CAS No.
- 64461-82-1
- Chemical Name:
- Tizanidine hydrochloride
- Synonyms
- AB-021;Gibonz;Zanpeak;TERNELIN;SIRDALUD;ZANAFLEX;Enchinin;Astonelin;DS-103-282;TIZANIDINE HCL
- CBNumber:
- CB8480703
- Molecular Formula:
- C9H9Cl2N5S
- Molecular Weight:
- 290.17
- MDL Number:
- MFCD00798231
- MOL File:
- 64461-82-1.mol
| Melting point | 280 °C |
|---|---|
| Flash point | 9℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: ~29 mg/mL |
| form | solid |
| color | white |
| Merck | 14,9485 |
| CAS DataBase Reference | 64461-82-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | B53E3NMY5C |
| NCI Drug Dictionary | tizanidine hydrochloride |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DK9910000 | |||||||||
| HS Code | 2934990002 | |||||||||
| NFPA 704 |
|
Tizanidine hydrochloride price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T-085 | Tizanidine hydrochloride 500?μg/mL in methanol, certified reference material, Cerilliant? | 64461-82-1 | 1mL | $98.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1667905 | Tizanidine hydrochloride United States Pharmacopeia (USP) Reference Standard | 64461-82-1 | 200mg | $732 | 2024-03-01 | Buy |
| TCI Chemical | T2527 | Tizanidine Hydrochloride >98.0%(HPLC)(T) | 64461-82-1 | 5g | $64 | 2024-03-01 | Buy |
| TCI Chemical | T2527 | Tizanidine Hydrochloride >98.0%(HPLC)(T) | 64461-82-1 | 25g | $192 | 2024-03-01 | Buy |
| Alfa Aesar | J67149 | Tizanidine hydrochloride 99% | 64461-82-1 | 5g | $93.9 | 2023-06-20 | Buy |
Tizanidine hydrochloride Chemical Properties,Uses,Production
Description
As an adrenergic agonist with muscle relaxant activity, tizanidine hydrochloride belongs to the hydrochloride salt form of tizanidine, which is commonly used in the treatment of spasticity, a condition where muscles in human body spasm, cramp, or become tight induced by a variety of medical problems such as multiple sclerosis, spinal cord injury, Lou Gehrig's disease, spastic diplegia, back pain or certain other injuries to the spine or central nervous system. Besides, as a sleep aid and an anticonvulsant, tizanidine hydrochloride has off-label usage for migraine headaches and is effective for some symptoms of fibromyalgia.
As a short-acting muscle relaxer, the antinociceptive effect of tizanidine hydrochloride functions by blocking excess nerve impulses (pain sensations) of the nerve cells that are sent to the brain and control muscle movement, ultimately resulting in muscle relaxation and spasticity alleviation.
References
https://en.wikipedia.org/wiki/Tizanidine
http://www.webmd.com/drugs/2/drug-1024/tizanidine-oral/details
http://bodyandhealth.canada.com/drug/getdrug/pal-tizanidine
https://pubchem.ncbi.nlm.nih.gov/compound/114869#section=Top
https://www.drugs.com/tizanidine.html
Chemical Properties
Off-White to pale Yellow Solid
Originator
Nimzox,Rapross Pharmaceuticals Pvt. Ltd.,India
Uses
Anticoagulant
Uses
Tizanidine (Zanaflex) is a drug that is used as a muscle relaxant. It is a centrally acting α-2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, spastic diplegia,
Uses
An α2-adrenergic agonist; centrally active myotonolytic. A muscle relaxant (skeletal).
Definition
ChEBI: Tizanidine hydrochloride is a benzothiadiazole.
Manufacturing Process
14 ml of benzoyl chloride are added to a solution of 11.5 g of ammonium thiocyanate in 150 ml of acetone in an ice bath and the mixture is then stirred for 10 min. This solution is heated to the boil at reflux together with 19 g of 4-amino-5-chloro-2,1,3-benzothiadiazole. The solution is cooled to room temperature and diluted with a 4-fold quantity of water. The precipitate is filtered off and rapidly brought to a boil together with 150 ml of a 2 N aqueous sodium hydroxide solution and kept at the boil for 5 min. The solution is cooled to room temperature, is acidified weakly with glacial acetic acid, the precipitate is filtered off, washed with ether and recrystallized from methanol. The N-(5-chloro-2,1,3-benzothiadiazol-4-yl)thiourea, obtained and this is boiled for 1 h together with 9 g of methyl iodide in 150 ml of methanol. After concentrating by evaporation, crude S-methyl-N-(5-chloro-2,1,3- benzothiadiazol-4-yl)isothiuronium iodide is obtained. 9.8 g of S-methyl-N-(5- chloro-2,1,3-benzothiadiazol-4-yl)isothiuronium iodide are heated to the boil at reflux for 1 h together with 50 ml of methanol and 1.8 ml of ethylene diamine. The solvent is then removed by evaporation and the moist residue is boiled at reflux for 1 h together with 20 ml of n-amyl alcohol. The mixture is subsequently shaken with 50 ml of chloroform and 150 ml of water until all the material is dissolved. 40 ml of a 2 N aqueous sodium hydroxide solution are added to the aqueous phase and extraction is effected with 200 ml of chloroform. The organic phase is dried and concentrated by evaporation. After recrystallizing the residue from methanol with the addition of some active charcoal, 4-(2-imidazolin-2-yl-amino)-5-chloro-2,1,3-benzothiadiazole, having a melting point of 221-223°C, is obtained. The 4-(2-imidazolin-2-yl-amino)-5-chloro-2,1,3-benzothiadiazole hydrochloride may be obtained by the teaction of 4-(2-imidazolin-2-yl-amino)-5-chloro- 2,1,3-benzothiadiazole with hydrochloric acid.
brand name
Tizanidine is INN and BAN.
Therapeutic Function
Muscle relaxant, Spasmolytic
Biological Activity
α 2 -adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC 50 = 48 nM). Also binds to imidazoline receptor.
storage
Desiccate at RT
Tizanidine hydrochloride Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Dalian Richfortune Chemicals Co., Ltd | 0411-84820922 8613904096939 | sales@richfortunechem.com | China | 303 | 57 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3632 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
View Lastest Price from Tizanidine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-08-18 | Tizanidine hydrochloride
64461-82-1
|
US $60.00 / KG | 25KG | 99.99% | 200ton | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-06-15 | Tizanidine hydrochloride
64461-82-1
|
US $1300.00 / KG | 1KG | 99 | 1T | Baoji Guokang Bio-Technology Co., Ltd. | |
 |
2021-11-02 | Tizanidine hydrochloride
64461-82-1
|
US $1280.00 / Kg/Bag | 1KG | 99% | 1T | Baoji Guokang Healthchem co.,ltd |
-
- Tizanidine hydrochloride
64461-82-1
- US $60.00 / KG
- 99.99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Tizanidine hydrochloride
64461-82-1
- US $1300.00 / KG
- 99
- Baoji Guokang Bio-Technology Co., Ltd.
-
- Tizanidine hydrochloride
64461-82-1
- US $1280.00 / Kg/Bag
- 99%
- Baoji Guokang Healthchem co.,ltd
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