3-O-Ethyl-L-ascorbic acid
- CAS No.
- 86404-04-8
- Chemical Name:
- 3-O-Ethyl-L-ascorbic acid
- Synonyms
- ETHYL ASCORBIC ACID;VCE;vitaMin C ethyl ether;VC ethyl ether;3-O-Ethyl Ascorbyl Ether;3-0-Ethyl Ascorbic acid;Ethyl ascorbyl ether;(R)-5-((S)-1,2-dihydroxyethyl)-4-ethoxy-3-hydroxyfuran-2(5H)-one;(5r)-5-[(1s)-1,2-dihydroxyethyl]-4-ethoxy-3-hydroxy-5h-furan-2-one;LGB-VCE
- CBNumber:
- CB8511566
- Molecular Formula:
- C8H12O6
- Molecular Weight:
- 204.18
- MDL Number:
- MFCD09261382
- MOL File:
- 86404-04-8.mol
- MSDS File:
- SDS
| Melting point | 112.0 to 116.0 °C |
|---|---|
| Boiling point | 551.5±50.0 °C(Predicted) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| vapor pressure | 0-0Pa at 20-25℃ |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Methanol (Slightly), Water (Slightly) |
| pka | 8.89±0.40(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C8H12O6/c1-2-13-7-5(11)8(12)14-6(7)4(10)3-9/h4,6,9-11H,2-3H2,1H3/t4-,6+/m0/s1 |
| InChIKey | ZGSCRDSBTNQPMS-UJURSFKZSA-N |
| SMILES | O(CC)C1=C(O)C(=O)O[C@@H]1[C@H](CO)O |
| LogP | -0.8--0.64 at 20-25℃ and pH7 |
| Surface tension | 69-72.4mN/m at 1g/L and 20℃ |
| EWG's Food Scores | 1 |
| FDA UNII | 6MW60CB71P |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| HS Code | 2936.27.0000 | |||||||||
| NFPA 704 |
|
3-O-Ethyl-L-ascorbic acid price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E0926 | 3-O-Ethyl-L-ascorbic Acid >98.0%(HPLC)(T) | 86404-04-8 | 5g | $42 | 2024-03-01 | Buy |
| TCI Chemical | E0926 | 3-O-Ethyl-L-ascorbic Acid >98.0%(HPLC)(T) | 86404-04-8 | 25g | $144 | 2024-03-01 | Buy |
| TRC | E922013 | 3-O-Ethyl-L-ascorbic Acid | 86404-04-8 | 100mg | $85 | 2021-12-16 | Buy |
| AK Scientific | W8865 | 3-O-Ethyl-L-ascorbic Acid | 86404-04-8 | 10g | $86 | 2021-12-16 | Buy |
| Chem-Impex | 31932 | 3-O-Ethyl-L-ascorbicacid,99%(HPLC) 99%(HPLC) | 86404-04-8 | 25G | $89.6 | 2021-12-16 | Buy |
3-O-Ethyl-L-ascorbic acid Chemical Properties,Uses,Production
Description
3-O-Ethyl ascorbic acid ether, also called VC ethyl ether, is an ascorbic acid derivative. Ascorbic acid is a naturally occurring antioxidant and free radical scavenger, a reducing agent in the conversion process of biological enzymes, and has a preventive effect on some chronic diseases (cancer, diabetes and allergic skin diseases). From the molecular structure of ascorbic acid, it can be seen that compared to the 2-position enol hydroxyl group, the 3-position enol hydroxyl group has higher activity on electrophiles, and it is the product of 3-O-alkylation during O-alkylation modification. Mainly. 3-O-Ethyl ascorbate ether is a product of ascorbic acid-3-O-ethylation. It has a simple molecular structure and is easily absorbed by the skin. After entering the dermis through the stratum corneum of the skin, it is easily decomposed by the biological enzymes in the human body. The effect of ascorbic acid effectively solves the fat solubility problem of ascorbic acid, and is widely used in cosmetics as a whitening agent and antioxidant.
Uses
Vitamin C ethyl ether (VC ethyl ether) is a lipophilic and hydrophilic amphoteric vitamin C derivative. It not only retains the redox effect of vitamin C but is also very stable. It is a non-discoloring vitamin C derivative. It is a lipophilic and chemicalbook amphoteric substance, which not only makes it extremely convenient to use in the formula, but also makes it easy to penetrate the stratum corneum into the dermis. After entering the skin, it is easily decomposed by biological enzymes to play the role of vitamin C, thereby Improve its bioavailability.
Uses
3-O-Ethyl-L-ascorbic Acid could be a useful stabilizing agent for a para-hydroxyacetophenone solution. It could be a useful stabilizing agent for a para-?hydroxyacetophenone solution.
Definition
ChEBI: 3-O-ethyl-l-ascorbic acid (EA) is a butenolide. It is an l-ascorbic acid derivative with an ethyl group at the third carbon position.
Health effects
3-O-ethyl-L-ascorbic acid improves the molecules' stability and its transportation efficacy to the skin, being absorbed faster and better. Additionally, it is less irritating to the skin. Cosmetic case studies demonstrate that they have skin brightening, collagen stimulating, and antioxidant properties.
Mechanism of action
VC ethyl ether penetrates the stratum corneum to reach the melanocytes in the basal layer, inhibits tyrosinase activity, inhibits the formation of melanin, and restores melanin to colorless, thereby effectively whitening the skin. And Chemicalbook and VC ethyl ether can directly participate in the synthesis of collagen and repair skin cell activity after entering the dermis, increasing collagen, so that the skin becomes full and elastic, making the skin delicate and smooth.
Synthesis
The above 3-O-ethyl-5,6-O-isopropylideneascorbic acid 40g dissolved in 200ml of ethanol. 10g of cation-exchange resin was added and was refluxed for 2 hours. The catalyst was removed by an ion exchange resin and concentrated under reduced pressure. After drying, with ethyl acetate: hexane (3: 1) crystallization. After drying, obtained 33.3g 3-O-ethylascorbic acid, yield 94%. It was recrystallized in 100mL ethyl acetate giving 30.6g, yield 87%, mp: 112-114??C.
3-O-Ethyl-L-ascorbic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| QINGDAO HONG JIN CHEMCIAL CO.,LTD. | 532-83657313 | hjt@hong-jin.com | China | 228 | 58 |
| Jinan Jianfeng Chemical Co., Ltd | 0531-88110457; +8615562555968 | info@pharmachemm.com | China | 246 | 58 |
| Zhuhai Hairuide Bioscience and Technology Co., Ltd | +8618928027945 | sales3@zhhairuide.com | China | 97 | 58 |
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 6452 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 | sales@sdperfect.com | China | 294 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| Wuhan Quanjinci New Material Co.,Ltd. | +8615271838296 | kyra@quanjinci.com | China | 1532 | 58 |
| Shanghai Affida new material science and technology center | +undefined15081010295 | 2691956269@qq.com | China | 359 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
Related articles
- 3-O-Ethyl-L-ascorbic acid: Benefits and Side effects
- 3-O-Ethyl-L-ascorbic acid is a water-soluble antioxidant that has been used in personal care formulations for many years.
- Dec 13，2023
- Application of 3-O-ethyl-L-ascorbic acid
- 3-O-ethyl-l-ascorbic acid (EA) is an l-ascorbic acid derivative with an ethyl group at the third carbon position.
- Jun 15，2022
View Lastest Price from 3-O-Ethyl-L-ascorbic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-19 | 3-O-Ethyl-L-ascorbic acid
86404-04-8
|
US $140.00 / KG | 1KG | 99% | 1000kg/month | Hebei Yime New Material Technology Co., Ltd. | |
 |
2024-04-19 | 3-O-Ethyl-L-ascorbic acid
86404-04-8
|
US $0.00 / Kg/Drum | 1KG | ≥99% | 200mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2024-04-17 | 3-O-Ethyl-L-ascorbic acid
86404-04-8
|
US $0.00-0.00 / kg | 0.1kg | 99.5% | 20ton | Hangzhou Zelixir Biotech Co., Ltd. |
-
- 3-O-Ethyl-L-ascorbic acid
86404-04-8
- US $140.00 / KG
- 99%
- Hebei Yime New Material Technology Co., Ltd.
-
- 3-O-Ethyl-L-ascorbic acid
86404-04-8
- US $0.00 / Kg/Drum
- ≥99%
- Jinan Finer Chemical Co., Ltd
-
- 3-O-Ethyl-L-ascorbic acid
86404-04-8
- US $0.00-0.00 / kg
- 99.5%
- Hangzhou Zelixir Biotech Co., Ltd.
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