3-Chloropropionyl chloride
- CAS No.
- 625-36-5
- Chemical Name:
- 3-Chloropropionyl chloride
- Synonyms
- 3-Chloropropanoyl chloride;Chloropropionyl chloride;oropropionyL;3-Chloropropionyl ch;3-Chlorpropionylchlorid;-Chloropropanoylchloride;3-Chloropropinyl chloride;3-chloro-propanoylchlorid;3-CHLOROPROPIONYL CHLORIDE;3-Chloropropionyl chlorode
- CBNumber:
- CB8691211
- Molecular Formula:
- C3H4Cl2O
- Molecular Weight:
- 126.97
- MDL Number:
- MFCD00000747
- MOL File:
- 625-36-5.mol
- MSDS File:
- SDS
| Melting point | -32 °C |
|---|---|
| Boiling point | 143-145 °C(lit.) |
| Density | 1.33 g/mL at 25 °C(lit.) |
| vapor pressure | 10.0 hPa |
| refractive index |
n |
| RTECS | UC3934000 |
| Flash point | 146 °F |
| storage temp. | Flammables area |
| solubility | Chloroform, Ethyl Acetate |
| form | liquid |
| color | red-brown |
| PH | <7 (H2O) |
| explosive limit | 8.8-20.2%(V) |
| Water Solubility | reacts |
| Sensitive | Moisture Sensitive |
| BRN | 635814 |
| Stability | Moisture Sensitive |
| InChIKey | INUNLMUAPJVRME-UHFFFAOYSA-N |
| CAS DataBase Reference | 625-36-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 24PO18998I |
| NIST Chemistry Reference | Propanoyl chloride, 3-chloro-(625-36-5) |
| EPA Substance Registry System | Propanoyl chloride, 3-chloro- (625-36-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H314-H330 | |||||||||
| Precautionary statements | P260-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 14-22-26-34-35-10 | |||||||||
| Safety Statements | 23-26-36/37/39-45-38-16-8 | |||||||||
| RIDADR | UN 3390 6.1/PG 1 | |||||||||
| WGK Germany | 1 | |||||||||
| F | 21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29159080 | |||||||||
| NFPA 704 |
|
3-Chloropropionyl chloride price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C69128 | 3-Chloropropionyl chloride 98% | 625-36-5 | 100g | $137 | 2024-03-01 | Buy |
| Sigma-Aldrich | 147443 | 3-Chloropropionyl chloride technical grade | 625-36-5 | 100ml | $56.4 | 2024-03-01 | Buy |
| Alfa Aesar | B25698 | 3-Chloropropionyl chloride, 97% | 625-36-5 | 100g | $78.8 | 2024-03-01 | Buy |
| TRC | C380600 | 3-Chloropropionyl chloride | 625-36-5 | 5g | $45 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC71810 | 3-Chloropropionyl chloride | 625-36-5 | 50g | $50 | 2021-12-16 | Buy |
3-Chloropropionyl chloride Chemical Properties,Uses,Production
Description
3-Chloropropionyl chloride is an important bifunctional reagent. It is capable of acylation and possesses a 2-chloro-ethyl fragment (CH2CH2Cl), which can be subjected to nucleophilic substitution and serves as a masked vinyl group. It can be used as a starting material in many reactions to construct a variety of (hetero)cyclic compounds.
Chemical Properties
Clear colorless to dark brown liquid. Soluble in ethanol, ether and chloroform. Slightly soluble in water.
Uses
3-Chloropropionyl chloride is a reagent used in the synthesis of Beclamide (B119400), which is a chlorinated benzylpropanamide used as an anticonvulsant drug. It is used in the treatment of tonic-clonic seizyres and has sedative properties.
Preparation
3-Chloropropionyl chloride (1) is commercially available and can be prepared from β-propiolactone (2) and thionyl chloride.1 Other standard methods available for the preparation of acyl chlorides can also be applied: the reaction of acrylic acid (3) or 3-chloropropionic acid (4) with thionyl chloride, phosphoryl chloride, phosgene, or phosphorus trichloride.
Reactions
(1) The Friedel¨CCrafts acylation of tert-butylbenzene (5) with 3-chloropropionyl chloride (1) followed by cyclization provid- ed indanone 6, which was further transformed into urea derivative 7, a potent TRPV1 antagonist. 
(2) A novel high-yielding one-pot microwave-assisted synthesis of condensed 5-substituted pyranoisoquinoline-1,6-diones 9 from 2-substituted isoquinoline-1,3-diones 8 and 3-chloropropionyl chloride (1) was reported. 
(3) Acylation of 2-aminophenol (12) with 3-chloropropionyl chloride (1), followed by cyclization in the presence of polyphosphoric acid (PPA), gave benzoxazole 13, which was further reacted with 4-chlorophenyl-1-piperazine to yield the target benzo[d]oxazole analogue 14, a selective dopamine D4 receptor ligand.
Flammability and Explosibility
Non flammable
Synthesis
3-Chloropropionyl chloride is produced by reaction of acrylic acid with hydrogen chloride and phosgene in the presence of, for example,dimethylformamide as catalyst, or by reaction of propiolactone with thionyl chloride.
Synthesis
3-Chloropropionyl chloride is produced by reaction of acrylic acid with hydrogen chloride and phosgene in the presence of, for example, dimethylformamide as catalyst, or by reaction of propiolactone with thionyl chloride.
3-Chloropropionyl chloride Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2169 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7786 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 6992 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
View Lastest Price from 3-Chloropropionyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-03 | 3-Chloropropionyl Chloride
625-36-5
|
US $140.00 / Kg | 1Kg | 99 % | 500 Kg | R&D Scientific Inc. | |
 |
2024-01-22 | 3-Chloropropionyl chloride
625-36-5
|
US $8.00-0.80 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-03-06 | Allylbenzene
625-36-5
|
US $9.10 / KG | 1KG | 99.% | 10 ton | Hebei Guanlang Biotechnology Co,.LTD |
-
- 3-Chloropropionyl Chloride
625-36-5
- US $140.00 / Kg
- 99 %
- R&D Scientific Inc.
-
- 3-Chloropropionyl chloride
625-36-5
- US $8.00-0.80 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Allylbenzene
625-36-5
- US $9.10 / KG
- 99.%
- Hebei Guanlang Biotechnology Co,.LTD
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