Bilirubin
- CAS No.
- 635-65-4
- Chemical Name:
- Bilirubin
- Synonyms
- Cholerythrin;BILIRUBIN MIXED ISOMERS;Biliyubin;Bilibubin;filirubin;BILIRUBIN;hemetoidin;HEMATOIDIN;1,19-dioxo-;BilirubinGr
- CBNumber:
- CB8693422
- Molecular Formula:
- C33H36N4O6
- Molecular Weight:
- 584.66
- MDL Number:
- MFCD00005499
- MOL File:
- 635-65-4.mol
- MSDS File:
- SDS
| Melting point | 192 °C |
|---|---|
| Boiling point | 641.7°C (rough estimate) |
| Density | 1.2163 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | -20°C |
| solubility | aqueous acid: soluble |
| form | powder |
| pka | 4.62±0.10(Predicted) |
| color | orange |
| Water Solubility | practically insoluble |
| Sensitive | Light Sensitive |
| Merck | 14,1218 |
| BRN | 74376 |
| Stability | Stable. Refrigerate. |
| NCI Dictionary of Cancer Terms | bilirubin |
| FDA UNII | RFM9X3LJ49 |
| EPA Substance Registry System | Bilirubin (635-65-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 62-36/37/38-20/21/22 | |||||||||
| Safety Statements | 22-24/25-36-26 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DU3038000 | |||||||||
| F | 8 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29339990 | |||||||||
| NFPA 704 |
|
Bilirubin price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B4126 | Bilirubin ≥98% (EmM/453 = 60), powder | 635-65-4 | 1g | $383 | 2024-03-01 | Buy |
| Sigma-Aldrich | B4126 | Bilirubin ≥98% (EmM/453 = 60), powder | 635-65-4 | 5g | $1360 | 2024-03-01 | Buy |
| Sigma-Aldrich | 2011 | Bilirubin - CAS 635-65-4 - Calbiochem Principal pigment of bile and one of the major end products of hemoglobin decomposition. | 635-65-4 | 1g | $251 | 2024-03-01 | Buy |
| Alfa Aesar | A17522 | Bilirubin 97% | 635-65-4 | 1g | $172 | 2023-06-20 | Buy |
| Alfa Aesar | A17522 | Bilirubin 97% | 635-65-4 | 5g | $638 | 2023-06-20 | Buy |
Bilirubin Chemical Properties,Uses,Production
Description
Bilirubin is a yellow breakdown product of heme catabolism, formed when heme is cleaved by heme oxygenase. This reaction produces carbon monoxide and biliverdin, which is rapidly reduced to bilirubin by biliverdin reductase. Bilirubin has key roles as a free radical scavenger with antioxidant and anti-inflammatory actions. Free and albumin-bound bilirubin can also scavenge nitric oxide (NO) and NO-related species. Unconjugated bilirubin is highly water-insoluble and must be conjugated with glucuronides to become water soluble and subsequently excreted by the liver and kidney.
Chemical Properties
Light Orange to Deep Redish-Brown Crystalline Solid
Uses
Bilirubin has been used:
- in phantom preparation
- in in vitro experiments
- in the preparation of bilirubin solutions for infusion
Uses
Principal pigment of bile and constituent of many biliary calculi
Uses
Bilirubin is widely utilized to monitor the liver function and their disease, such as hepatitis or cirrhosis; or the effects of medicines which are damage the liver. It acts as a pigment in certain algae to capture light energy. Its double bonds are isomerizes in the presence of light, which is employed in phototherapy of jaundiced newborns babies. It is used to detect the blocking in bile ducts.
Definition
Red coloring matter of bile. Also occurs in blood serum as decomposition product of hemoglobin.
General Description
Bilirubin, a heme catabolism end-product is produced by the reduction of its metabolic precursor biliverdin by the action of enzyme biliverdin reductase.
Biochem/physiol Actions
Bilirubin is an active oxidative DNA cleaving agent as well as an effective antioxidant agent, a hydroxyl radical quencher. This bile pigment has both antioxidant and toxic properties. It is a natural inhibitor of vascular smooth muscle cell proliferation (VSMCs). It displays anti-inflammatory and anti-proliferative properties when used as a therapeutic agent in lung/vascular diseases. Serum bilirubin concentration slightly above the normal levels have shown a lesser incidence of heart disease. It is a potential therapeutic agent in heart transplantation and T-cell mediated immune disorders.
Purification Methods
An acyclic tetrapyrrole bile pigment with impurities which can be eliminated by successive Soxhlet extraction with diethyl ether and MeOH. It crystallises from CHCl3 as deep red-brown rhombs, plates or orange-red prisms from chlorobenzene (m 330o dec) and is dried to constant weight at 80o under vacuum. [Gray et al. J Chem Soc 2264, 2276 1961, Beilstein 26 III/IV 3268.]
Bilirubin Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Duly Biotech Co.,Ltd | +undefined18013301590 | melody@njduly.com | China | 2452 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12457 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7613 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
View Lastest Price from Bilirubin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-12 | Bilirubin
635-65-4
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | |
 |
2024-03-27 | Bilirubin
635-65-4
|
US $5.00-0.10 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-10-17 | Bilirubin
635-65-4
|
US $0.00 / kg | 1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. |
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