HUMAN CNTF
- CAS No.
- 133423-39-9
- Chemical Name:
- HUMAN CNTF
- Synonyms
- CNF;CNTF;Anti-HCNTF;HUMAN CNTF;CNTF, HUMAN;RECOMBINANT HUMAN CNTF;CILIARY NEUROTROPHIC FACTOR;HUMAN CILIARY NEUROTROPHIC FACTOR;CILIARY NEUROTROPHIC FACTOR, HUMAN;Anti-CNTF antibody produced in goat
- CBNumber:
- CB8755968
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00676720
- MOL File:
- Mol file
| storage temp. | −20°C |
|---|---|
| form | lyophilized powder |
| FDA UNII | CR102F038W |
HUMAN CNTF price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB2501382 | Anti-CNTF antibody produced in goat affinity isolated antibody, buffered aqueous solution | 133423-39-9 | 100μg | $568 | 2024-03-01 | Buy |
| Sigma-Aldrich | C3710 | Ciliary Neurotrophic Factor human CNTF, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture | 133423-39-9 | 10μG | $258 | 2023-06-20 | Buy |
| Sigma-Aldrich | C3710 | Ciliary Neurotrophic Factor human CNTF, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture | 133423-39-9 | 20μG | $367 | 2023-06-20 | Buy |
| Usbiological | 139731 | CNTF | 133423-39-9 | 200ul | $432 | 2021-12-16 | Buy |
| Usbiological | 382424 | CNTF | 133423-39-9 | 96Tests | $729 | 2021-12-16 | Buy |
HUMAN CNTF Chemical Properties,Uses,Production
Uses
Ciliary Neurotrophic Factor human has been used to study its effect on photoreceptor neuroprotection and Muller glial cell proliferation in zebrafish retina. It has also been used to study the effects of intravitreal injection of ciliary neurotrophic factor (CNTF) on photoreceptor injury and BRB (blood-retinal barrier) breakdown in transgenic model.
General Description
The CNTF (ciliary neurotrophic factor) gene encodes a cytokine, and is mapped to human chromosome 11q12.1.
Biochem/physiol Actions
Ciliary neurotrophic factor (CNTF) was first identified as a survival factor for neurons from the ciliary ganglion of chicken embryos. Most of its known actions are restricted to cells of the nervous system, including motor neurons, sympathetic ganglion neurons, sensory neurons, hippocampal neurons, and medial septal neurons. CNTF also prevents degeneration of motor axons after axotomy and promotes astrocyte differentiation and oligodendrocyte survival and maturation. Outside the nervous system, CNTF maintains embryonic stem cells in an undifferentiated, pluripotent state. CNTF is structurally related to leukemia inhibitory factor (LIF), interleukin-6 (IL-6), interleukin-11 (IL-11) and oncostatin M (OSM). CNTF exerts its actions through the activation of the high-affinity CTNF receptor complex, which contains the ligand-binding α-subunit (CNTF Rα) and two signal transducing β-subunits (LIF Rβ and gp130). The LIF Rβ subunit is also shared by receptors for LIF and OSM. The gp130 subunit is also shared by receptors for LIF, OSM, IL-6, and IL-11. CNTF is localized in the cell nucleus subsequent to receptor binding. Human and rat CNTF share ~83% sequence homology and show cross-reactivity in bioactivity.
HUMAN CNTF Preparation Products And Raw materials
Raw materials
Preparation Products
HUMAN CNTF Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Kanglang Biotechnology Co., Ltd. | 021-61998208 18217752821 | sales@klbio.cn | China | 9617 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | chenjw@absin.cn | China | 24734 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10054 | 58 |
| Shanghai Yaji Biological Technology Co., Ltd. | 021-34661275 15301693058 | yajikit@163.com | China | 7111 | 58 |
| Shanghai Yingxin Laboratory Equipment Co., Ltd. | 021-021-59178156 17002132182 | 3146474380@qq.com | China | 11609 | 58 |
| Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 | sales@shzbio.com | China | 9965 | 58 |
| ACROBiosystems | 18514007688 | jiaxin.zhao@acrobiosystems.com | China | 831 | 58 |