Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]-
![Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]- Structure](CAS/20210111/GIF/2225836-30-4.gif)
- CAS No.
- 2225836-30-4
- Chemical Name:
- Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]-
- Synonyms
- ACH-000143;Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]-;N-(2-(5-chloro-2,6-dimethoxy-1H-benzo[d]imidazol-1-yl)ethyl)acetamide;Melatonin Receptor,HFD,toxicity,low,steatosis,Inhibitor,ACH-000143,inhibit,ACH 000143,obese,ACH000143
- CBNumber:
- CB88376516
- Molecular Formula:
- C13H16ClN3O3
- Molecular Weight:
- 297.74
- MDL Number:
- MFCD34167540
- MOL File:
- 2225836-30-4.mol
Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0159650 | ACH-000143 | 2225836-30-4 | 5mg | $300 | 2021-12-16 | Buy |
| ChemScene | CS-0159650 | ACH-000143 | 2225836-30-4 | 10mg | $480 | 2021-12-16 | Buy |
| ChemScene | CS-0159650 | ACH-000143 | 2225836-30-4 | 25mg | $950 | 2021-12-16 | Buy |
| ChemScene | CS-0159650 | ACH-000143 | 2225836-30-4 | 50mg | $1450 | 2021-12-16 | Buy |
| ChemScene | CS-0159650 | ACH-000143 | 2225836-30-4 | 100mg | $2250 | 2021-12-16 | Buy |
Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]- Chemical Properties,Uses,Production
Biological Activity
ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively[1]. ACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats[1].ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate[1].ACH-000143 significantly reduces plasma glucose at 10 mg/kg (-16.4%, p < 0.05) and 30 mg/kg (-16.9%, p < 0.01)[1].
References
[1]. Marcos Antonio Ferreira Jr, et al. Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats. J Med Chem. 2021 Feb 25;64(4):1904-1929.
Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4691 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4182 | 55 | |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4740 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8015 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9833 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9242 | 58 |