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Meptazinol

CAS No.
54340-58-8
Chemical Name:
Meptazinol
Synonyms
MeptaMizol;MEPTAZINOL;Meptazinol A;Meptazinol-13C-d3;Meptazinol USP/EP/BP;MEPTAZINOL 54340-58-8;3-(3-ethyl-1-Methylazepan-3-yl)phenol;3-(1-Methyl-3-ethylhexahydro-1H-azepine-3-yl)phenol;3-(3-ethylhexahydro-1-methyl-1h-azepin-3-yl)-phenol;Phenol, 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-
CBNumber:
CB8841562
Molecular Formula:
C15H23NO
Molecular Weight:
233.35
MDL Number:
MFCD00864339
MOL File:
54340-58-8.mol
Last updated:2023-05-04 17:34:39

Meptazinol Properties

Melting point 127-133°C
Boiling point 354.8±35.0 °C(Predicted)
Density 0.997
pka 9.95±0.10(Predicted)
FDA UNII 18Y7S5JKZD
ATC code N02AX05

Pharmacokinetic data

Protein binding 27%
Excreted unchanged in urine <5%
Volume of distribution 3.1(L/kg)
Biological half-life 1.4-4 / -

Meptazinol price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0008709 MEPTAZINOL 95.00% 54340-58-8 1MG $460 2021-12-16 Buy
American Custom Chemicals Corporation API0008709 MEPTAZINOL 95.00% 54340-58-8 5MG $518 2021-12-16 Buy
American Custom Chemicals Corporation API0008709 MEPTAZINOL 95.00% 54340-58-8 10MG $574 2021-12-16 Buy
Chemenu CM200523 3-(3-ethyl-1-methylazepan-3-yl)phenol 97% 54340-58-8 5g $505 2021-12-16 Buy
Product number Packaging Price Buy
API0008709 1MG $460 Buy
API0008709 5MG $518 Buy
API0008709 10MG $574 Buy
CM200523 5g $505 Buy

Meptazinol Chemical Properties,Uses,Production

Originator

Meptid,Wyeth,UK,1983

Uses

Analgesic.

Definition

ChEBI: 3-(3-ethyl-1-methyl-3-azepanyl)phenol is a member of azepanes.

Manufacturing Process

2-(m-Methoxyphenyl)butyronitrile in dry ether was added to a stirred suspension of sodium amide in liquid ammonia. The mixture was stirred for 30 minutes then ethyl-4-iodobutyrate (99.25 g, 0.4 mol) in dry ether (200 ml) was added dropwise. The mixture was stirred at the temperature of refluxing liquid ammonia for 5 hours. Ammonium chloride (10 g) was added and the mixture allowed to warm to room temperature. Water (300 ml) was added, the organic layer separated, washed with water, 2 N sulfuric acid and water. After drying over magnesium sulfate and removing the ether, the product was distilled yielding ethyl 5-cyano-5-(mmethoxyphenyl)heptanoate.
That material was hydrogenated in cyclohexane using a Raney nickel catalyst. The product after distillation was recrystallized from ethyl acetate affording 10.0 g of 6-ethyl-(m-methoxyphenyl)hexahydro-2H-azepin-2one, MP 87°C to 88°C.
The azepinone (9.1 g) in dry tetrahydrofuran (50 ml) and ether (50 ml) was added dropwise to a stirred suspension of aluminum lithium hydride (7.5 g) in dry ether (50 ml). After heating under reflux for 3 hours the reaction mixture was worked up and distilled yielding 7.66 g of a compound which was a colorless oil, BP 108°C to 110°C/0.01 mm.
That product was then heated under reflux with 50% hydrobromic acid for 1.5 hours. The reaction mixture was evaporated to dryness and reevaporated with three portions of propan-2-ol. The oil obtained was dissolved in propan-2-ol and diluted with ether. 3-Ethyl-3-(m-hydroxyphenyl)hexahydro-1H-azepine was obtained. That material in turn was reductively methylated by hydrogenation in the presence of formaldehyde in absolute ethanol solution to give 3-ethyl-3-(m-methoxyphenyl)-1-methylhexahydro-1H-azepine.
The methoxy group was converted to a hydroxy group by refluxing with 80% HBr giving meptazinol hydrobromide.

Therapeutic Function

Analgesic

Clinical Use

Opioid analgesic used for moderate to severe pain

Drug interactions

Potentially hazardous interactions with other drugs
Antidepressants: possible CNS excitation or depression with MAOIs - avoid; possible CNS excitation or depression with moclobemide; possibly increased sedative effects with tricyclics.
Antihistamines: increased sedative effects with sedating antihistamines.
Antipsychotics: enhanced hypotensive and sedative effects.
Dopaminergics: avoid with selegiline.
Nalmefene: avoid concomitant use.
Sodium oxybate: enhanced effect of sodium oxybate - avoid

Metabolism

Meptazinol is extensively metabolised in the liver and is excreted mainly in the urine as the glucuronide conjugate. Less than 10% of a dose has been recovered from the faeces.

Meptazinol Preparation Products And Raw materials

Global( 57)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Standardpharm Co. Ltd.
86-714-3992388 overseasales1@yongstandards.com United States 14336 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569265 +86-18612256290 1056@dideu.com China 3959 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17368 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
AFINE CHEMICALS LIMITED
0571-85134551 info@afinechem.com CHINA 15377 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
LUYUNJIA CHEMISTRY XIAMEN LIMITED
+86-592-5360779 +86-13055435203 China 5996 58

View Lastest Price from Meptazinol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Meptazinol pictures 2022-02-18 Meptazinol
54340-58-8
US $0.00 / gram 1gram 99% 10kg Zhejiang J&C Biological Technology Co.,Limited
Meptazinol pictures 2021-07-20 Meptazinol
54340-58-8
US $1.00-1.00 / Kg/Bag 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
Meptazinol USP/EP/BP pictures 2021-06-11 Meptazinol USP/EP/BP
54340-58-8
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
  • Meptazinol pictures
  • Meptazinol
    54340-58-8
  • US $0.00 / gram
  • 99%
  • Zhejiang J&C Biological Technology Co.,Limited
  • Meptazinol pictures
  • Meptazinol
    54340-58-8
  • US $1.00-1.00 / Kg/Bag
  • 99%
  • Shaanxi Dideu Medichem Co. Ltd
MEPTAZINOL 3-(3-ethylhexahydro-1-methyl-1h-azepin-3-yl)-phenol 3-(1-Methyl-3-ethylhexahydro-1H-azepine-3-yl)phenol (+/-)-3-(3-ethyl-1-Methylhexahydro-1H-azepin-3-yl)phenol Meptazinol A 3-(3-ethyl-1-Methylazepan-3-yl)phenol MeptaMizol Meptazinol-13C-d3 Phenol, 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)- Meptazinol USP/EP/BP MEPTAZINOL 54340-58-8 54340-58-8