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Actinomycin D

Actinomycin D
Actinomycin D
CAS No.
50-76-0
Chemical Name:
Actinomycin D
Synonyms
ad;actd;acto-d;nsc3053;AD(VAN);cosmegen;Cosmogen;nci-c04682;nci-co4682;oncostatink
CBNumber:
CB8853701
Molecular Formula:
C62 H86 N12 O16
Formula Weight:
1255.44
MOL File:
50-76-0.mol

Actinomycin D Properties

Melting point:
251-253 °C
Flash point:
87℃
storage temp. 
2-8°C
solubility 
ethanol, DMSO: Stable in aqueous solutions at 2-8 °C.soluble
form 
powder
color 
red, powder
Water Solubility 
SOLUBLE
Merck 
13,2828
Stability:
Stable, but light sensitive, especially in dilute solution. Incompatible with strong acids, strong bases, strong oxidizing agents. Combustible.
CAS DataBase Reference
50-76-0(CAS DataBase Reference)
EPA Substance Registry System
Actinomycin D(50-76-0)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T+
Risk Statements  28-61-40-45-26/27/28
Safety Statements  53-36/37/39-45-1-36/37-28-22
RIDADR  UN 3462 6.1/PG 2
WGK Germany  3
RTECS  AU1575000
8-10-21
HazardClass  6.1(a)
PackingGroup  II
HS Code  29419000
Hazardous Substances Data 50-76-0(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H227 Combustible liquid Flammable liquids Category 4 Warning P210, P280, P370+P378, P403+P235,P501
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
Precautionary statements:
P201 Obtain special instructions before use.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P403+P235 Store in a well-ventilated place. Keep cool.

Actinomycin D price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 114666 Actinomycin D 50-76-0 1set $236 2017-11-08 Buy
Sigma-Aldrich 01815 Actinomycin D for fluorescence, ≥90% (HPLC), from 50-76-0 10mg-f $237 2017-11-08 Buy
Alfa Aesar J67160 Actinomycin D, 1 mg/ml in DMSO, sterile-filtered 50-76-0 1ml $73.5 2017-11-08 Buy
Alfa Aesar J60148 Actinomycin D 50-76-0 5mg $88.3 2017-11-08 Buy
Cayman Chemical 11421 Actinomycin D ≥95% 50-76-0 5mg $52 2017-11-08 Buy

Actinomycin D Chemical Properties,Uses,Production

Chemical Properties

red crystalline powder

Uses

An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent.

Uses

antineoplastic, intercalating agent

Uses

Actinomycin D is the most studied member of a family of unique bicyclic depsipeptides produced by several Streptomyces species. The depsipeptides are linked by a heterocyclic benzoxazone "anchor" that gives the metabolites a highly distinctive red/orange colour. Actinomycin D exhibits potent antibiotic and antitumour activity via DNA intercalation leading to the inhibition of nucleic acid synthesis. Tumour cell death has been demonstrated to occur by apoptosis.

Uses

Actinomycin D is the most studied member of a family of unique bicyclic depsipeptides produced by several Streptomyces species. The depsipeptides are linked by a heterocyclic benzoxazone "anchor" that gives the metabolites a highly distinctive red/orange colour. Actinomycin D exhibits potent antibiotic and antitumor activity via DNA intercalation leading to the inhibition of nucleic acid synthesis. Tumor cell death has been demonstrated to occur by apoptosis.

Uses

Antibiotic substance belonging to the actinomycin complex, produced by several Streptomyces spp. Antineoplastic

General Description

Bright red rhomboid prisms or red powder.

Air & Water Reactions

Water soluble.

Reactivity Profile

Actinomycin D can react with strong oxidizing agents, strong acids and strong bases.

Fire Hazard

Flash point data for Actinomycin D are not available. Actinomycin D is probably combustible.

Biological Activity

Anti-neoplastic antibiotic. Inhibits RNA polymerase and is a potent inducer of apoptosis.

Actinomycin D Preparation Products And Raw materials

Raw materials

Preparation Products


Actinomycin D Suppliers

Global( 182)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Chongqing Chemieliva Pharmaceutical Co., Ltd. +86 (23) 6777-0219
+86 (23) 6777-0220 jessica.hu@chemieliva.com China 212 60
Hangzhou J&H Chemical Co., Ltd. +86-0571-87396432 87396430
+86-0571-87396431 sales@jhechem.com China 14050 53
Nanjing Sunlida Biological Technology Co., Ltd. 025-58378339;025-57798810
025-57019371 sales@sunlidabio.com China 3856 55
Shanghai Hanjing Chemicals Co., Ltd. +86 (21) 5428 5032
+86 (21) 5443 7651 gerry.shu@hanjingchemicals.com China 52 55
Nanjing PengRui Biological Co., Ltd. 025-58885431 18912924980
025-58889303 571960571@qq.com China 840 58
Shanghai Boyle Chemical Co., Ltd. 86-15221043597
86-21-57758967 sales@boylechem.com China 2848 55
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 6019 61
BeiJing Hwrk Chemicals Limted 4006990298;010-57411839;0757-86311057;021-51691807
010-87653215;0757-86311057;021-55236763 sales@hwrkchemical.com China 15553 55
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1960 70
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32527 50

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