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4'-Hydroxypropiophenone

4'-Hydroxypropiophenone Structure
4'-Hydroxypropiophenone structure
CAS No.
70-70-2
Chemical Name:
4'-Hydroxypropiophenone
Synonyms
PHP;b360;B 360;H-365;Mepal;Frenon;Paroxon;VANATONE;Bio-Fren;Hypostat
CBNumber:
CB8854142
Molecular Formula:
C9H10O2
Molecular Weight:
150.17
MDL Number:
MFCD00008745
MOL File:
70-70-2.mol
MSDS File:
SDS
Last updated:2024-03-26 17:16:27
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4'-Hydroxypropiophenone Properties

Melting point 36-38 °C(lit.)
Boiling point 152-154 °C26 mm Hg(lit.)
Density 1.09 g/cm3 (20℃)
refractive index 1.5360 (estimate)
FEMA 2005 | ACETANISOLE
Flash point >230 °F
storage temp. Store below +30°C.
solubility methanol: 0.1 g/mL, clear
form Solid
pka 8.87±0.26(Predicted)
color White
Water Solubility 0.34 g/l (15 ºC)
Merck 14,7044
BRN 907511
LogP 2.030
CAS DataBase Reference 70-70-2(CAS DataBase Reference)
EWG's Food Scores 1
NCI Dictionary of Cancer Terms PHP
FDA UNII X9952001TG
NIST Chemistry Reference 1-Propanone, 1-(4-hydroxyphenyl)-(70-70-2)
EPA Substance Registry System 1-Propanone, 1-(4-hydroxyphenyl)- (70-70-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xn,Xi
Risk Statements  36/37/38
Safety Statements  37-24/25-36-26
WGK Germany  3
RTECS  UH1925000
TSCA  Yes
HS Code  29145000
Toxicity LD50 orally in Rabbit: 11800 mg/kg
NFPA 704
1
2 0

4'-Hydroxypropiophenone price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H55405 4′-Hydroxypropiophenone 98% 70-70-2 100g $39.96 2024-03-01 Buy
Sigma-Aldrich 8.20692 4′-Hydroxypropiophenone for synthesis 70-70-2 100g $70.4 2024-03-01 Buy
TCI Chemical H0299 4'-Hydroxypropiophenone >98.0%(GC) 70-70-2 25g $28 2024-03-01 Buy
TCI Chemical H0299 4'-Hydroxypropiophenone >98.0%(GC) 70-70-2 500g $161 2024-03-01 Buy
Alfa Aesar A15314 4'-Hydroxypropiophenone, 99% 70-70-2 100g $41.65 2024-03-01 Buy
Product number Packaging Price Buy
H55405 100g $39.96 Buy
8.20692 100g $70.4 Buy
H0299 25g $28 Buy
H0299 500g $161 Buy
A15314 100g $41.65 Buy

4'-Hydroxypropiophenone Chemical Properties,Uses,Production

Chemical Properties

white powder

Uses

p-Hydroxypropiophenone is a 4-hydroxyphenyl ketone used in the preparation of potential antitumor agents. p-Hydroxypropiophenone is a lignin degrradation product.

Uses

Intermediates of Liquid Crystals

Uses

gonadotropic hormone inhibitor

Preparation

Preparation by Fries rearrangement of phenyl propionate
with aluminium chloride in refluxing carbon disulfide ? then at 130–150° for 2–3 h after solvent elimination (45–50%)
with aluminium chloride in nitrobenzene at 50° for 18 h (72%) or at ? 20° for 48 h (60%)
with aluminium chloride in nitromethane at 20° for 7–8 days (80%)
with aluminium chloride in chlorobenzene using microwave irradiation for ? 3 min at 106° (62%)
with aluminium chloride in ethylene dichloride at 95° for 5 h or in heptane at ? 80–90° for 7 h (36%), in benzene or in tetrachloroethane at 80°; with aluminium chloride in the presence of propionyl chloride at 50–60° for ? 6 h (49%)
with aluminium chloride without solvent at 50° for 10 h
with titanium tetrachloride in nitromethane at 20° for 7 days (56%) or ? without solvent at 50° for 10 h (39%)
with polyphosphoric acid at 100° (61%)
with boron trifluoride at 50° for 3 h (46%)
with stannic chloride at 50° for 3 h (10%).

Definition

ChEBI: P-Hydroxypropiophenone is a member of acetophenones.

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 2491, 1965 DOI: 10.1021/jo01018a528

Safety Profile

Poison by intraperitoneal, subcutaneous, and parenteral routes. An experimental teratogen. Other experimental reproductive effects. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

target

Estrogen receptor

Purification Methods

4'-Hydroxypropiophenone [70-70-2] M 150.2, m 149o, b 140-145o/0.5mm, 8.05. Crystallise the phenone from H2O (m 149.8-150.2o) or EtOH (m 147o). The benzoyl derivative has m 117o, and the semicarbazone has m 183o (EtOH). [Beilstein 8 H 102, 8 II 104, 8 III 379.]

4'-Hydroxypropiophenone synthesis

79-03-8
108-95-2
70-70-2
Synthesis of 4'-Hydroxypropiophenone from Propionyl chloride and Phenol

4'-Hydroxypropiophenone Preparation Products And Raw materials

Raw materials

Carbon disulfide phenyl propionate Methoxypropiophenone Benzenemethanol, α-ethyl-4-hydroxy- 4-BENZYLOXYPROPIOPHENONE
4'-Bromopropiophenone 4-Propylphenol

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Preparation Products

2'-Hydroxypropiophenone 4-Propanoylphenyl 2,2-dimethylpropanoate 4-(4-hydroxyphenyl)-5-methyl-1,3-hiazol-2-amine 1-(3,5-Dibromo-4-hydroxyphenyl)-1-propanone 1-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]PROPAN-1-ONE
(E/Z)-1-[4-(2-Chloroethoxy)phenyl]-2-(4-hydroxyphenyl)-1-phenyl-1-butene 1-[4-(difluoromethoxy)phenyl]propan-1-amine

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4'-Hydroxypropiophenone Suppliers

Global( 561)Suppliers
Supplier Tel Email Country ProdList Advantage
Changzhou Ditong Chemical Co.,Ltd
+86-0519-88299272 info@edengenechem.com China 2169 58
ZHEJIANG JIUZHOU CHEM CO., LTD
+86-0576225566889 +86-13454675544 admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com China 20000 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12456 58
Dorne Chemical Technology co. LTD 		+86-13583358881 +86-18560316533 Ethan@dornechem.com China 294 58
Shandong Hanjiang Chemical Co., Ltd 		+86-0533-2066820 +8618369939125 hanson@sdhanjiang.com China 1527 58
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 885 50
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1807 55
Supplier Advantage
Changzhou Ditong Chemical Co.,Ltd
58
ZHEJIANG JIUZHOU CHEM CO., LTD
58
Hebei Mojin Biotechnology Co., Ltd 		58
Dorne Chemical Technology co. LTD 		58
Shandong Hanjiang Chemical Co., Ltd 		58
Frapp's ChemicalNFTZ Co., Ltd. 		50
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55

View Lastest Price from 4'-Hydroxypropiophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4'-Hydroxypropiophenone pictures 2024-04-25 4'-Hydroxypropiophenone
70-70-2
 US $10.00 / ASSAYS 1ASSAYS 99% 10 ton Dorne Chemical Technology co. LTD
4'-Hydroxypropiophenone pictures 2024-04-12 4'-Hydroxypropiophenone
70-70-2
 US $0.00 / kg 1kg 0.99 10T Shandong Hanjiang Chemical Co., Ltd
4'-Hydroxypropiophenone pictures 2024-01-08 4'-Hydroxypropiophenone
70-70-2
 US $35.00-30.00 / KG 1KG 99.9% 5 tons per week Wuhan Boyuan Import & Export Co., LTD

4'-Hydroxypropiophenone Spectrum

4'-Hydroxypropiophenone(70-70-2)1HNMR4'-Hydroxypropiophenone(70-70-2)IR14'-Hydroxypropiophenone(70-70-2)Raman

70-70-2(4'-Hydroxypropiophenone)Related Search:

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4-Hydroxyphenethyl alcohol Sodium 4-hydroxybenzenesulfonate 4-Hydroxyphenylacetic acid Tyramine 4-CHLORO-4'-HYDROXYBUTYROPHENONE
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PARA-ETHYLKETOPHENOL PARA-PROPIONYLPHENOL 4-HYDROXYPROPIOPHENONE / PAROXYPROPIONE 1-(4-hydroxyphenyl)propan-1-one 4''-HYDROXYPROPRIOPHENONE 4′-Hydroxypropiophen P-acetone 4'-Hydroxypropiophenone, 97+% 4'-Hydroxypropiophenone≥ 99.0% (HPLC) P-HYDROXYPROPIOPHENONE P-HYDROXYL PROPIOPHENONE P-METHOXYACETOPHENONE PAROXYPROPIONE PARA METHOXY ACETOPHENONE VANATONE 1-(4-hydroxyphenyl)-1-propanon 1-(4-Hydroxyphenyl)-1-propanone 1-(p-Hydroxyphenyl)-1-Propanone 4’-hydroxy-propiophenon LABOTEST-BB LT00855519 LABOTEST-BB LT01595901 ETHYL 4-HYDROXYPHENYL KETONE FEMA 2005 AURORA 5371 p-Methylbenzoic Acid Methyl Ether ACETANISOLE AKOS 90580 AKOS BBS-00003225 AKOS BBS-00003216 4-METHOXYPHENYLETHANONE 4-HYDROXYPHENYL ETHYL KETONE 4'-HYDROXYPROPIOPHENONE 4-HYDROXYPROPIOPHENONE 4-ACETOANISOLE 4-ACETYLANISOLE (4-Hydroxyphenyl)-1-propanone 4'-HYDROXY PROPIOPHENONE P-HYDROXYPHENYLETHYLKETONE 4-HydoxyPropiophenone 4'-Hydroxypropiophenone, 98+% P-Hydroxyl 1-Propanone, 1-(4-hydroxyphenyl)- P-HYDROXYPHENYLETHYLKETONE 1-(4-METHOXYPHENYL)ETHANONE hydrolytic polyacrylamide 4-Hydroxypropiophenon 4-Propanoylphenol 4-Propionylphenol B 360 b360 Bio-Fren Ethyl p-hydroxyphenyl ketone ethylp-hydroxyphenylketone Frenantol Frenohypon Frenon Frenormon H-365 Hydroxypropiophenone