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MRTX1133

MRTX1133 structure

CAS No.: 2621928-55-8

Chemical Name:: MRTX1133

Synonyms: MRTX1133;KRAS,Ras,MRTX 1133,G12D,cells,active,wild-type,phosphorylation,mutant,MRTX1133,inactive,ERK,inhibit,tumor,states,MRTX-1133,Inhibitor;4-(4-(3,8-Diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol;4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-Naphthalenol;2-Naphthalenol, 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-;4-[4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[[(2S,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoronaphthalen-2-ol

CBNumber:: CB89021600

Molecular Formula:: C33H31F3N6O2

Molecular Weight:: 600.63

MDL Number:: MFCD34567005

MOL File:: 2621928-55-8.mol

Last updated:2024-05-13 11:56:04

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MRTX1133 Properties

Density	1.49±0.1 g/cm3(Predicted)
solubility	DMSO:50.0(Max Conc. mg/mL);83.24(Max Conc. mM)
form	A solid
pka	8.05±0.40(Predicted)
InChIKey	SCLLZBIBSFTLIN-IFMUVJFISA-N
SMILES	C1=C2C(C(C#C)=C(F)C=C2)=C(C2N=CC3=C(N4CC5NC(CC5)C4)N=C(OC[C@]45C[C@@H](F)CN4CCC5)N=C3C=2F)C=C1O
FDA UNII	DU32DM9CHD

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P321-P305+P351+P338-P332+P313-P362+P364-P337+P313

NFPA 704

	0
2		0

MRTX1133 Chemical Properties,Uses,Production

Uses

MRTX1133 is a potent and selective KRAS G12D inhibitor that targets KRAS G12D protein in both the active and inactive states. In preclinical studies, MRTX1133 exhibited a long half-life, was able to bind to KRAS G12D protein in both active and inactive states, and selectively inhibited KRAS G12D-mutated cancer cells. In G12D mutant tumor models, it showed dose-dependent selective inhibition of the KRAS pathway and tumor regression.

Chemical Properties

Solid powder.

storage

Dry, dark and at 0-4℃ for short term (days to weeks) or -20℃ for long term (months to years).

MRTX1133 Preparation Products And Raw materials

Raw materials

Preparation Products

MRTX1133 Suppliers

Global( 86)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4398	58
Hubei Chuchang Biotech Co., Ltd.	+86-18727130788 +86-18727130788	info@chuchangbiotech.com	China	100	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	7019	58
Nanjing Shizhou Biotechnology Co., Ltd	+86-15850508050 +86-15850508050	sean.lv@synzest.com	China	323	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12719	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58

Supplier	Advantage
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Hubei Chuchang Biotech Co., Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
Jinan Carbotang Biotech Co.,Ltd.	58
Nanjing Shizhou Biotechnology Co., Ltd	58
Zhengzhou Alfa Chemical Co.,Ltd	58
Zhejiang J&C Biological Technology Co.,Limited	58
LEAP CHEM CO., LTD.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58

Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor
MRTX1133, discovered through extensive structure-based activity improvement, is a potent, selective, non-covalent KRASG12D inh....
Sep 26，2022

View Lastest Price from MRTX1133 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-05-15	MRTX1133 2621928-55-8	US $0.00-0.00 / MG	1MG	98	100G	Hubei Chuchang Biotech Co., Ltd.

MRTX1133
2621928-55-8
US $0.00-0.00 / MG
98
Hubei Chuchang Biotech Co., Ltd.

2621928-55-8(MRTX1133)Related Search:

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2-Naphthalenol, 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro- 4-(4-(3,8-Diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol MRTX1133 4-[4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[[(2S,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoronaphthalen-2-ol KRAS,Ras,MRTX 1133,G12D,cells,active,wild-type,phosphorylation,mutant,MRTX1133,inactive,ERK,inhibit,tumor,states,MRTX-1133,Inhibitor 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-Naphthalenol 2621928-55-8 C33H31F3N6O2