Cucurbitacin IIb
- CAS No.
- 50298-90-3
- Chemical Name:
- Cucurbitacin IIb
- Synonyms
- Hemslecin B;Cucurbitacin Ⅱb;cucuritacin IIB;Cucurbitacin IIb;23,24-Dihydrocucurbitacin F;(10α)-2β,3α,16α,20,25-Pentahydroxy-9β-methyl-19-norlanost-5-ene-11,22-dione;19-Norlanost-5-ene-11,22-dione, 2,3,16,20,25-pentahydroxy-9-methyl-, (2β,3α,9β,10α,16α)-;(1S,2S,4R,9β,16α,17ξ)-1,2,16,20,25-pentahydroxy-9,10,14-trimethyl-4,9-cyclo-9,10-secocholest-5-ene-11,22-dione;(2S,3S,8S,9R,10R,13R,14S,16R,17R)-17-[(2R)-2,6-dihydroxy-6-methyl-3-oxoheptan-2-yl]-2,3,16-trihydroxy-4,4,9,13,14-pentamethyl-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-11-one
- CBNumber:
- CB91267775
- Molecular Formula:
- C30H48O7
- Molecular Weight:
- 520.7
- MDL Number:
- MFCD02752610
- MOL File:
- 50298-90-3.mol
- MSDS File:
- SDS
Cucurbitacin IIb price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 300125 | Cucurbitacin IIb | 50298-90-3 | 10mg | $433 | 2021-12-16 | Buy |
| ApexBio Technology | N2200 | Cucurbitacin B | 50298-90-3 | 20mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-0018308 | CucurbitacinIIb >99.0% | 50298-90-3 | 10mg | $457 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb259180 | Cucurbitacin IIb 98% | 50298-90-3 | 10mg | $472.6 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PXT0005262 | DIHYDROCUCURBITACIN F 95.00% | 50298-90-3 | 5MG | $500.15 | 2021-12-16 | Buy |
Cucurbitacin IIb Chemical Properties,Uses,Production
Description
Cucurbitacin IIa and cucurbitacin IIb are the characteristic chemical constituents of the hemsleya. Hemsleyadinum are extracted from the Cucurbitaceae, Chrysanthemum, and Hemsleya, which have the function of clearing heat and removing toxicity and antisepsis and anti-inflammation. There are 31 species of Hemsleya in the world, most of which are distributed in China’s Yunnan, Guizhou, and Sichuan provinces, besides the 2 species distributed in India and Vietnam. The main species are H. emiensis, H. pengxianensis, H. amabilis, H. dolichocarpa, H. graciliflora, and H. gigantha . Hemsleya plants are commonly used as Chinese herbal medicines.
Physical properties
Appearance: rhombohedral or flaky crystals, Solubility: soluble in methanol, ethanol, and acetone, slightly soluble in chloroform, insoluble in water.
History
Hemsleyadinum and hemsloside inhibit Shigella dysenteriae, Salmonella typhimurium, and Salmonella choleraesuis in?vitro. Intravenous injection of cucurbitacin IIa has mild antipyretic effect caused by intraperitoneal injection of typhoid and paratyphoid bacteria but invalid to those with normal body temperature and nonbacterial fever. Xuedansu tablets have significant antitussive effect and show inhibitory effect against p-xylene-induced mouse ear swelling and carrageenaninduced rat toe swelling. Cucurbitacin IIa and cucurbitacin IIb also have anti-HIV-1 activity, which plays a vital role in HIV-1 virus infection . Hemsleyadinum has significant protective effect against acute liver injury caused by CCl4, especially at the high dosage .
Indications
Its dosage forms and indications are available at the Pharmacopoeia of the People’s Republic of China (1977). The current clinical use of hemsleyadinum includes tablets and capsules, which are suitable for bacillary dysentery, enteritis, bronchitis, and acute tonsillitis.
Pharmacology
The main active ingredient in Cucurbitaceae plants is cucurbitacins, and cucurbitacin IIa and IIb have been used in clinics. Their indications include bacillary dysentery, enteritis, bronchitis, acute tonsillitis, and so on. Cucurbitacin IIa also has anticancer effect . Cucurbitacin IIa (25–100?μM) dose-dependently inhibits proliferation of human lung adenocarcinoma A549 and mouse adenocarcinoma. It blocks the G0/G1 and S phase of A549 cells and thus promotes cell apoptosis . The anticancer mechanism of cucurbitacin IIa is to prevent cancer cell spreading by destroying cytoskeleton of actin and leading to PARP-induced apoptosis by inhibiting production of downstream surviving of JAK/STAT3.
Clinical Use
At present, hemsleyadinum mainly are used as antibacterial and anti-inflammatory drugs, suitable for treatment of upper respiratory tract infection, acute tonsillitis, mumps, pharyngitis, acute and chronic bronchitis, pneumonia etc. Generally speaking, hemsleyadinum and its preparations have less side effects, such as diarrhea, abdominal pain, and other gastrointestinal reactions.
Cucurbitacin IIb Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253 | jancyzheng@gcgreenpure.com | China | 952 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 2263 | 58 |
View Lastest Price from Cucurbitacin IIb manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-24 | Cucurbitacin IIb
50298-90-3
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2020-05-03 | Cucurbitacin IIb
50298-90-3
|
US $0.00-0.00 / KG | 1KG | 99.0% | 800 tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-14 | Cucurbitacin IIb
50298-90-3
|
US $1.00 / KG | 1KG | 99% | 25kg | Career Henan Chemical Co |
-
- Cucurbitacin IIb
50298-90-3
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Cucurbitacin IIb
50298-90-3
- US $0.00-0.00 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- Cucurbitacin IIb
50298-90-3
- US $1.00 / KG
- 99%
- Career Henan Chemical Co