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Lidocaine

description Chemical property Uses
Lidocaine
Lidocaine
CAS No.
137-58-6
Chemical Name:
Lidocaine
Synonyms
Xilina;Xllina;Xyline;Anbesol;L-Caine;Rucaina;Solcain;Xycaine;Xylotox;Cuivasil
CBNumber:
CB9128024
Molecular Formula:
C14H22N2O
Formula Weight:
234.34
MOL File:
137-58-6.mol

Lidocaine Properties

Melting point:
66-69°C
Boiling point:
bp4 180-182°; bp2 159-160°
Flash point:
9℃
storage temp. 
Store at RT
solubility 
ethanol: 4 mg/mL
form 
powder
color 
White to slightly yellow
Water Solubility 
practically insoluble
Merck 
14,5482
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
137-58-6(CAS DataBase Reference)
NIST Chemistry Reference
Lidocaine(137-58-6)
EPA Substance Registry System
Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)- (137-58-6)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,T,F
Risk Statements  22-39/23/24/25-23/24/25-11
Safety Statements  22-26-36-45-36/37-16-7
RIDADR  3249
WGK Germany  3
RTECS  AN7525000
HazardClass  6.1(b)
PackingGroup  III
Hazardous Substances Data 137-58-6(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Lidocaine price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L-018 Lidocaine solution 1.0mg/mL in methanol, ampule of 1mL, certified reference material 137-58-6 018-1ml $25.5 2017-11-08 Buy
Sigma-Aldrich 1366002 Lidocaine United States Pharmacopeia (USP) Reference Standard 137-58-6 250mg $348.4 2017-11-08 Buy
TCI Chemical L0156 Lidocaine >99.0%(HPLC)(T) 137-58-6 25g $40 2017-12-01 Buy
TCI Chemical L0156 Lidocaine >99.0%(HPLC)(T) 137-58-6 100g $56 2017-12-01 Buy
Sigma-Aldrich PHR1034 Lidocaine Pharmaceutical Secondary Standard; Certified Reference Material 137-58-6 1g $58.7 2017-11-08 Buy

Lidocaine Chemical Properties,Uses,Production

description

Lidocaine is a local anesthetic, also known as Xylocaine, in recent years it has been replaced procaine, widely used in local infiltration anesthesia in cosmetic plastic surgery, it can block the nerve excitability and conduction by inhibiting the sodium channels of nerve cell membrane. The fat soluble and protein binding rate of lidocaine is higher than procaine, its cell penetrating ability is strong, fast onset, long duration of action, the interaction strength is 4 times of procaine.
Lidocaine is used in infiltration anesthesia, epidural anesthesia, topical anesthesia (including thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve block. In order to extend the time of anesthesia, reduce the poisoning of lidocaine and other side effects, can be added in the anesthetic epinephrine.
Lidocaine can also be used for the treatment of ventricular premature beat after acute myocardial infarction, ventricular tachycardia, digitalis poisoning, cardiac surgery and cardiac catheterization-induced ventricular arrhythmias, including ventricular premature beats, ventricular tachycardia and ventricular fibrillation. Lidocaine is also used for duration status of epilepsy which other anti-seizure drugs are not effective, as well as local or spinal anesthesia. But it is usually ineffective for supraventricular arrhythmias.

Chemical property

Lidocaine is white needle like crystals, and its melting point is 68-69℃; boiling point is 180-182℃ (0.53kPa), soluble in ethanol in 159-160℃ (0.267kPa), ether, benzene, chloroform and oil, do not dissolve in water. In common use radical hydrochloride, lidocaine hydrochloride (C14H22N2O • HCL, [73-78-9]) is a white crystalline powder. Melting point 127-129℃, and the monohydrate melting point is 77-78℃. Easily soluble in water, 0.5% aqueous solution pHO 4.0-5.5. Odorless, bitter taste.

Uses

1, This product is a local anesthetics of amide derivatives,and widely used in surface anesthesia, anesthesia, conduction anesthesia and epidural anesthesia. The LD50 of oral lidocaine hydrochloride to mice was 290 mg/kg.
2, Used as a local anesthetic.

Chemical Properties

solid

Uses

Lidocaine (Alphacaine)is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. [1] Histamine is responsible for many features of allergic reactions. Lidocaine (Alphacaine)is a second-generation antihistamine agent closely st

Uses

antihypertensive

Uses

Anticonvulsant

Uses

Antiarrhythmic Agents, Anesthetics

Definition

ChEBI: The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Biological Activity

Anasthetic and class Ib antiarrhythmic agent.? Blocks voltage-gated sodium channels in the inactivated state.

Lidocaine Preparation Products And Raw materials

Raw materials

Preparation Products


Lidocaine Suppliers

Global( 238)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 10013 55
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Innovation Medicine Technology Co.,LTD
+86-0311-80690116 15716910116
+86-0311-80690116 sales@innovation-api.com CHINA 93 50
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3229 55
Wuxi Morality Chemical Co.,Ltd --
-- sales@chinamoralitychem.com China 387 50
Wuhan Hezhong Bio-chemical Manufacture co ltd 021-68580715 / 18930710487
nikki@pharm-china.com China 2016 55
Hubei YuanCheng SaiChuang Technology Co., Ltd. 021-68580270 18121115343
021-68580972 foodinfo@yccreate.com China 287 55
Yichang Yongnuo Pharmaceutical Co., Ltd. 15571779144/0717-4128488
0717-4460150 sales@yongnuopharm.com;653914859@qq.com China 2410 58
Hefei TNJ Chemical Industry Co.,Ltd. +86 (551) 65418684 65418696
+86 (551) 65418697 info@tnjchem.com China 1944 62
Jinan Jianfeng Chemical Co., Ltd. 0531-88110457 88259573
+86 (531) 8811-3608 info@pharmachemm.com China 154 58

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