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Lidocaine

Local anesthetics Chemical property Uses Production method

CAS No.137-58-6
Chemical Name:Lidocaine
Synonyms:Xilina;Xllina;Xyline;Anbesol;L-Caine;Rucaina;Solcain;Xycaine;Xylotox;Cuivasil
CBNumber:CB9128024
Molecular Formula:C14H22N2O
Formula Weight:234.34
MOL File:137-58-6.mol
Lidocaine Property
Melting point : 66-69°C
storage temp. : Store at RT
solubility : ethanol: 4 mg/mL
form : powder
Water Solubility : practically insoluble
Merck : 5482
Stability:: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference: 137-58-6(CAS DataBase Reference)
NIST Chemistry Reference: Lidocaine(137-58-6)
EPA Substance Registry System: Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)- (137-58-6)
Safety
Hazard Codes : Xn,T,F
Risk Statements : 22-39/23/24/25-23/24/25-11
Safety Statements : 22-26-36-45-36/37-16-7
RIDADR : 3249
WGK Germany : 3
RTECS : AN7525000
HazardClass : 6.1(b)
PackingGroup : III
Hazardous Substances Data: 137-58-6(Hazardous Substances Data)

Lidocaine Chemical Properties,Usage,Production

Local anesthetics
Lidocaine is a local anesthetic, also known as Xylocaine, in recent years it has been replaced procaine, widely used in local infiltration anesthesia in cosmetic plastic surgery, it can block the nerve excitability and conduction by inhibiting the sodium channels of nerve cell membrane. The fat soluble and protein binding rate of lidocaine is higher than procaine, its cell penetrating ability is strong, fast onset, long duration of action, the interaction strength is 4 times of procaine.
Lidocaine is used in infiltration anesthesia, epidural anesthesia, topical anesthesia (including thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve block. In order to extend the time of anesthesia, reduce the poisoning of lidocaine and other side effects, can be added in the anesthetic epinephrine.
Lidocaine can also be used for the treatment of ventricular premature beat after acute myocardial infarction, ventricular tachycardia, digitalis poisoning, cardiac surgery and cardiac catheterization-induced ventricular arrhythmias, including ventricular premature beats, ventricular tachycardia and ventricular fibrillation. Lidocaine is also used for duration status of epilepsy which other anti-seizure drugs are not effective, as well as local or spinal anesthesia. But it is usually ineffective for supraventricular arrhythmias.
Chemical property
Lidocaine is white needle like crystals, and its melting point is 68-69℃; boiling point is 180-182℃ (0.53kPa), soluble in ethanol in 159-160℃ (0.267kPa), ether, benzene, chloroform and oil, do not dissolve in water. In common use radical hydrochloride, lidocaine hydrochloride (C14H22N2O • HCL, [73-78-9]) is a white crystalline powder. Melting point 127-129℃, and the monohydrate melting point is 77-78℃. Easily soluble in water, 0.5% aqueous solution pHO 4.0-5.5. Odorless, bitter taste.
Uses
1, This product is a local anesthetics of amide derivatives,and widely used in surface anesthesia, anesthesia, conduction anesthesia and epidural anesthesia. The LD50 of oral lidocaine hydrochloride to mice was 290 mg/kg.
2, Used as a local anesthetic.
Production method
Lidocaine is derived from 2,6-dimethylaniline by acylation and amination. 1. Acylation:2,6-dimethylaniline dissolved in anhydrous benzene, cooled to 28℃ below, stirring and slowly dropping chloroacetyl chloride, controlling the temperature at 30℃ below. The reaction was then stirred for 1 h, and then heated to reflux 8h. Cooling, crystallizing, filtering and drying to obtain 2, 6-dimethyl chloroacetanilide, yield 75%. 2. Amination: added 2, 6-dimethyl chloroacetanilide to benzene, and then add diethylamine, stirring heated to reflux 7h. After recovery most of the benzene, cooling crystallization, filtration, washing crystallization with benzene. Combined with benzene liquid, extracted with 10% hydrochloric acid, added activated carbon decolorization in extract and filtered. Filtrate was adjusted to pH 10 with 10% sodium hydroxide solution, precipitation crystallization, rejection filter, washed to neutral, it was lidocaine. Recrystallization, salt with hydrochloric acid is the lidocaine hydrochloride. The yield of the amination reaction was 76%.
Chemical Properties
solid
Usage
Lidocaine (Alphacaine)is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. [1] Histamine is responsible for many features of allergic reactions. Lidocaine (Alphacaine)is a second-generation antihistamine agent closely st
Usage
antihypertensive
Usage
Anticonvulsant
Usage
Antiarrhythmic Agents, Anesthetics
Definition
ChEBI: The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Biological Activity
Anasthetic and class Ib antiarrhythmic agent.? Blocks voltage-gated sodium channels in the inactivated state.
Lidocaine Preparation Products And Raw materials
Raw materials
N-Methylaniline Lidocaine hydrochloride Diethylamine [(2,6-DIMETHYLPHENYL)AMINOCARBONYLMETHYL]CHLORIDE Chloroacetyl chloride
Preparation Products
Lidocaine Suppliers      Global( 203)Suppliers     
SupplierTelFaxEmailCountryProdListAdvantage
Wuxi Morality Chemical Co.,Ltd ----sales@chinamoralitychem.comCHINA 388 50
Wuhan Hezhong Bio-chemical Manufacture co ltd 021-68580270 / 18121115343 ycyg@yuanchengtech.comCHINA 1991 55
Hubei YuanCheng SaiChuang Technology Co., Ltd. 021-68580270 18121115343021-68580972foodinfo@yccreate.comCHINA 287 55
Yichang Yongnuo Pharmaceutical Co., Ltd. 15572799336/0717-41284880717-4460150sales@yongnuopharm.com;334072254@qq.comCHINA 2427 58
Hefei TNJ Chemical Industry Co.,Ltd. +86 (551) 65418684 65418696+86 (551) 65418697info@tnjchem.comCHINA 1899 62
Jinan Jianfeng Chemical Co., Ltd. 0531-88110457 83130510 83130502 +86 (531) 8811-3608info@pharmachemm.comCHINA 163 58
Hubei YiKangYuan Chemical Co., Ltd. 027-87182908 027-87182808 18064088908027-87182900sales@ykychem.comCHINA 97 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833+86-10-82849933jkinfo@jkchemical.com;market6@jkchemical.comCHINA 96839 76
Changzhou Sunchem Pharmaceutical Chemical Material Co., Ltd +86-519-85195575; 85195565; 15861192208+86-519-85195585info@sunkechem.comCHINA 111 69
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-59487313(Beijing)+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing)sh@meryer.comCHINA 40406 62
 
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