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Lidocaine

description Chemical property Uses

CAS No. 137-58-6
Chemical Name: Lidocaine
Synonyms: Xilina;Xllina;Xyline;Anbesol;L-Caine;Rucaina;Solcain;Xycaine;Xylotox;Cuivasil
CBNumber: CB9128024
Molecular Formula: C14H22N2O
Formula Weight: 234.34
MOL File: 137-58-6.mol
Lidocaine Property
Melting point : 66-69°C
Fp : 9℃
storage temp. : Store at RT
solubility : ethanol: 4 mg/mL
form : powder
color : White to slightly yellow
Water Solubility : practically insoluble
Merck : 5482
Stability:: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference: 137-58-6(CAS DataBase Reference)
NIST Chemistry Reference: Lidocaine(137-58-6)
EPA Substance Registry System: Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)- (137-58-6)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : Xn,T,F
Risk Statements : 22-39/23/24/25-23/24/25-11
Safety Statements : 22-26-36-45-36/37-16-7
RIDADR : 3249
WGK Germany : 3
RTECS : AN7525000
HazardClass : 6.1(b)
PackingGroup : III
Hazardous Substances Data: 137-58-6(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Lidocaine Chemical Properties,Usage,Production

description
Lidocaine is a local anesthetic, also known as Xylocaine, in recent years it has been replaced procaine, widely used in local infiltration anesthesia in cosmetic plastic surgery, it can block the nerve excitability and conduction by inhibiting the sodium channels of nerve cell membrane. The fat soluble and protein binding rate of lidocaine is higher than procaine, its cell penetrating ability is strong, fast onset, long duration of action, the interaction strength is 4 times of procaine.
Lidocaine is used in infiltration anesthesia, epidural anesthesia, topical anesthesia (including thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve block. In order to extend the time of anesthesia, reduce the poisoning of lidocaine and other side effects, can be added in the anesthetic epinephrine.
Lidocaine can also be used for the treatment of ventricular premature beat after acute myocardial infarction, ventricular tachycardia, digitalis poisoning, cardiac surgery and cardiac catheterization-induced ventricular arrhythmias, including ventricular premature beats, ventricular tachycardia and ventricular fibrillation. Lidocaine is also used for duration status of epilepsy which other anti-seizure drugs are not effective, as well as local or spinal anesthesia. But it is usually ineffective for supraventricular arrhythmias.
Chemical property
Lidocaine is white needle like crystals, and its melting point is 68-69℃; boiling point is 180-182℃ (0.53kPa), soluble in ethanol in 159-160℃ (0.267kPa), ether, benzene, chloroform and oil, do not dissolve in water. In common use radical hydrochloride, lidocaine hydrochloride (C14H22N2O • HCL, [73-78-9]) is a white crystalline powder. Melting point 127-129℃, and the monohydrate melting point is 77-78℃. Easily soluble in water, 0.5% aqueous solution pHO 4.0-5.5. Odorless, bitter taste.
Uses
1, This product is a local anesthetics of amide derivatives,and widely used in surface anesthesia, anesthesia, conduction anesthesia and epidural anesthesia. The LD50 of oral lidocaine hydrochloride to mice was 290 mg/kg.
2, Used as a local anesthetic.
Chemical Properties
solid
Uses
Lidocaine (Alphacaine)is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. [1] Histamine is responsible for many features of allergic reactions. Lidocaine (Alphacaine)is a second-generation antihistamine agent closely st
Uses
antihypertensive
Uses
Anticonvulsant
Uses
Antiarrhythmic Agents, Anesthetics
Definition
ChEBI: The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Biological Activity
Anasthetic and class Ib antiarrhythmic agent.? Blocks voltage-gated sodium channels in the inactivated state.
Lidocaine Preparation Products And Raw materials
Raw materials
N-Methylaniline Lidocaine hydrochloride Diethylamine [(2,6-DIMETHYLPHENYL)AMINOCARBONYLMETHYL]CHLORIDE Chloroacetyl chloride
Preparation Products
Lidocaine Suppliers      Global( 229)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Innovation Medicine Technology Co.,LTD +86-0311-80690116 15716910116
+86-0311-80690116 sales@innovation-api.com CHINA 95 50
Shenzhen Sendi Biotechnology Co.Ltd. 0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3230 55
Wuxi Morality Chemical Co.,Ltd --
-- sales@chinamoralitychem.com China 388 50
Wuhan Hezhong Bio-chemical Manufacture co ltd 021-68580715 / 18930710487
nikki@pharm-china.com China 2017 55
Hubei YuanCheng SaiChuang Technology Co., Ltd. 021-68580270 18121115343
021-68580972 foodinfo@yccreate.com China 287 55
Yichang Yongnuo Pharmaceutical Co., Ltd. 15571779144/0717-4128488
0717-4460150 sales@yongnuopharm.com;653914859@qq.com China 2420 58
Hefei TNJ Chemical Industry Co.,Ltd. +86 (551) 65418684 65418696
+86 (551) 65418697 info@tnjchem.com China 1944 62
Jinan Jianfeng Chemical Co., Ltd. 0531-88110457 83130510 83130502
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Hubei YiKangYuan Chemical Co., Ltd. 027-87182908 027-87182808 18064088908
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Wuhan HongxinKang Fine Chemical Co., Ltd. 18672345876
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137-58-6(Lidocaine)Related Search:
Procaine hydrochloride Bis(2,2,6,6-tetramethyl-4-piperidyl)sebacate N-(2,6-DIISOPROPYLPHENYL-CARBAMOYLMETHYL)IMINODIACETIC ACID Nefiracetam Bupivacaine LIDOCAINE HCL HYDRATE,LIDOCAINE HYDROCHLORIDE, MONOHYDRATE,LIDOCAINE HYDROCHLORIDE DAB, PH.EUR.,Lidocaine HCl USP Bupivacaine hydrochloride N-[2-(2-ETHYL-6-METHYLANILINO)-2-OXO-1-PHENYLETHYL]-2-FLUORO-N-ISOBUTYLBENZAMIDE N-(2,4,6-TRIMETHYLPHENYLCARBAMOYLMETHYL)IMINO-DIACETIC ACID, 98 N-[2-(2,6-DIMETHYLANILINO)-1-(4-HYDROXYPHENYL)-2-OXOETHYL]-2-FLUORO-N-ISOBUTYLBENZAMIDE N-(2,6-DIETHYLPHENYLCARBAMOYLMETHYL)IMINODIACETIC ANHYDRIDE LIDOCAINE N-ETHYL BROMIDE,LIDOCAINE N-ETHYL BROMIDE (QUATERNARY SALT) Denatonium benzoate (3-BROMO-2,4,6-TRIMETHYLPHENYLCARBAMOYL)METHYLIMINODIACETIC ACID LIDOFLAZINE, 98.5% denatonium saccharide LIDOCAINE HYDROCHLORIDE, [CARBONYL-14C] Lidocaine
2-(Diethylamino)-2',6'-acetoxylidide 2-(diethylamino)-2’,6’-acetoxylidide 2-(diethylamino)-n-(2,6-dimethylphenyl)-acetamid 2',6'-Acetoxylidide, 2-(diethylamino)- 6’-acetoxylidide,2-(diethylamino)-2 Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)- Acetamide,2-(diethylamino)-N-(2,6-dimethylphenyl)- a-Diethylamino-2,6-acetoxylidide alfa-Dietilamino-2,6-dimetilacetanilide alpha-(Diethylamino)-2,6-acetoxylidide alpha-diethylamino-2,6-acetoxylidide alpha-Diethylamino-2,6-dimethylacetanilide alpha-Diethylaminoaceto-2,6-xylidide Anbesol Anestacon Broncaine Cappicaine Cito optadren component of Cracked heel relief cream component of Emla cream component of Neosporin plus Cuivasil Dalcaine Diethylaminoacet-2,6-xylidide Diethylaminoaceto-2,6-xylidide Duncaine Esracaine Gravocain Isicaina Isicaine L-Caine Leostesin Lida-Mantle Lidocaine M Lidothesin Ligoncaine Maricaine Mesocain N-Di-ethylaminoacetyl-2,6-dimethylaniline omega-Diethylamino-2,6-dimethylacetanilide Remicaine Rucaina Solarcaine aloe extra burn relief cream Solcain Xilina Xilocaina Xllina Xycaine Xylestesin Xyline Xylocain Xylocitin Xyloneural (free base) Xylotox Monovalent Ion Channels Ion Channels Sodium Channel Modulators Voltage-gated Ion Channels
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