Afimoxifene
- CAS No.
- 68392-35-8
- Chemical Name:
- Afimoxifene
- Synonyms
- 4-HT;C016601;Alfecifene;AFIMOXIFENE;4-OHT 4-hydroxy;4-Oht hydrotamoxifen;4-Monohydroxytamoxifen;Tamoxifen metabolite B;Afimoxifene cas 68392-35-8;(E/Z)-4-Hydroxy Tamoxifen
- CBNumber:
- CB91353793
- Molecular Formula:
- C26H29NO2
- Molecular Weight:
- 387.51
- MDL Number:
- MOL File:
- 68392-35-8.mol
| Melting point | 135-144°C |
|---|---|
| Boiling point | 514.4±50.0 °C(Predicted) |
| Density | 1.092 |
| storage temp. | 2-8°C |
| solubility | methanol: soluble10mg/mL |
| form | solution |
| pka | 9.38±0.15(Predicted) |
| color | white to off-white |
| FDA UNII | 17197F0KYM |
| NCI Drug Dictionary | afimoxifene |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H361 | |||||||||
| Precautionary statements | P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 63-20/21/22 | |||||||||
| Safety Statements | 22-23-36 | |||||||||
| RIDADR | UN1170 - class 3 - PG 2 - Ethanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SL1210000 | |||||||||
| NFPA 704 |
|
Afimoxifene price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H6278 | 4-Hydroxytamoxifen ≥70% Z isomer (remainder primarily E-isomer) | 68392-35-8 | 10mg | $95.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | 94873 | 4-Hydroxytamoxifen ( | 68392-35-8 | 10mg | $218 | 2024-03-01 | Buy |
| Cayman Chemical | 17308 | (E/Z)-4-hydroxy Tamoxifen ≥98% (E) and (Z) isomers (50:50) | 68392-35-8 | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 17308 | (E/Z)-4-hydroxy Tamoxifen ≥98% (E) and (Z) isomers (50:50) | 68392-35-8 | 10mg | $61 | 2024-03-01 | Buy |
| Sigma-Aldrich | T176 | 4-Hydroxytamoxifen analytical standard, ( | 68392-35-8 | 10mg | $88.8 | 2024-03-01 | Buy |
Afimoxifene Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
A selective estrogen receptor modulator.
Uses
(E/Z)-4-Hydroxy Tamoxifen is selective estrogen receptor modulator.
Definition
ChEBI: Afimoxifene is a tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen. It has a role as an antineoplastic agent, an estrogen receptor antagonist and a metabolite. It is a tertiary amino compound and a member of phenols. It is functionally related to a tamoxifen.
brand name
TamoGel (Ascend Therapeutics).
General Description
4-Hydroxytamoxifen is a first generation, selective estrogen receptor modulator (SERM) that functions as an antagonist in breast cancer cells but can display estrogen-like activities in the uterus and bone.
Biological Activity
4-hydroxytamoxifen is an estrogen receptor modulator.estrogen receptor can be selectively stimulated or inhibited, providing promising therapeutic opportunities for auto-immune diseases, prostate and breast cancer, as well as depression.
Biochem/physiol Actions
Metabolite of the chemotherapeutic drug tamoxifen, exhibiting more potent estrogen agonist/antagonist activity than the parent drug. Also active as intra-membranous inhibitor of lipid peroxidation.
in vitro
previous study was conducted to evaluate the effects of tamoxifen and its active metabolite 4-hydroxytamoxifen on isolated rat cardiac myocyte mechanical function and calcium handling. results showed that myocytes treated with 4-hydroxytamoxifen had similarly to tamoxifen-treated cells to both calcium handling and contractility [1].
in vivo
previous animal study compared the extent of dna adduct formation in sd rats treated with seven tamoxifen or 4-hydroxytamoxifen. results showed that the liver weights and microsomal rates were not changed by tamoxifen or 4-hydroxytamoxifen treatment. moreover, the uterine weights were significantly decreased and uterine peroxidase activity was marginally decreased in tamoxifen or 4-hydroxytamoxifen treated rats. in addition, hepatic dna adduct levels in rats treated with 4-hydroxytamoxifen did not differ from control rats. similaryly, the adduct levels in uterus dna from rats treated with tamoxifen or 4-hydroxytamoxifen were not different from those in control rats [2].
IC 50
27 and 18 μm for mcf-7 and mda-mb-231 cell proliferation
storage
-20°C
References
[1] asp ml,martindale jj,metzger jm. direct, differential effects of tamoxifen, 4-hydroxytamoxifen, and raloxifene on cardiac myocyte contractility and calcium handling. plos one.2013 oct 24;8(10):e78768.
[2] beland fa,mcdaniel lp,marques mm. comparison of the dna adducts formed by tamoxifen and 4-hydroxytamoxifen in vivo. carcinogenesis.1999 mar;20(3):471-7.
[3] lee o et al. a randomized phase ii presurgical trial of transdermal 4-hydroxytamoxifen gel versus oral tamoxifen in women with ductal carcinoma in situ of the breast. clin cancer res.2014 jul 15;20(14):3672-82.
Afimoxifene Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 | mcbio_sales@163.com | China | 2255 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
View Lastest Price from Afimoxifene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-06-10 | Afimoxifene
68392-35-8
|
US $10.00 / kg | 0.1kg | 98% | 10000kg | Gihi Chemicals Co., Limited | |
 |
2020-02-05 | Afimoxifene
68392-35-8
|
US $1.00 / KG | 1KG | 98%-99.9%HPLC | 100KG | Career Henan Chemical Co |
-
- Afimoxifene
68392-35-8
- US $10.00 / kg
- 98%
- Gihi Chemicals Co., Limited
-
- Afimoxifene
68392-35-8
- US $1.00 / KG
- 98%-99.9%HPLC
- Career Henan Chemical Co