Hygromycin B
- CAS No.
- 31282-04-9
- Chemical Name:
- Hygromycin B
- Synonyms
- HYGROMYCIN B HYDRATE;950U/MG;Hygromix;Hygrovetin;hygromix-8;hygrovetine;hygromix2.4;hydromycinb;antihelmycin;Hyaromycin B
- CBNumber:
- CB9219683
- Molecular Formula:
- C20H37N3O13
- Molecular Weight:
- 527.52
- MDL Number:
- MFCD06795480
- MOL File:
- 31282-04-9.mol
| Melting point | 160-180°C |
|---|---|
| alpha | D20 +20.2° (c = 1 in water) |
| Boiling point | 608.13°C (rough estimate) |
| Density | 1.4252 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 30 days. |
| form | powder |
| pka | 7.1, 8.8(at 25℃) |
| color | faintly brown to brown |
| PH | pH (25g/l, 25℃ ) : 9.5～12.5 |
| Water Solubility | Miscible with water, methanol, buffer solution and ethanol. Immiscible with less polar solvents. |
| Merck | 14,4852 |
| BRN | 6755837 |
| Stability | Hygroscopic |
| FDA 21 CFR | 556.330; 558.274; 558.4 |
| FDA UNII | 3XQ2233B0B |
| EPA Substance Registry System | Hygromycin B (31282-04-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H330 | |||||||||
| Precautionary statements | P260-P264-P270-P271-P284-P304+P340+P310 | |||||||||
| Hazard Codes | T+,Xn,T | |||||||||
| Risk Statements | 26/27/28-41-42/43-40-36-23/24/25 | |||||||||
| Safety Statements | 23-26-28-36/37/39-45-22-36-36/37 | |||||||||
| RIDADR | UN 3462 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | WK2130000 | |||||||||
| F | 19 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29419059 | |||||||||
| Toxicity | mmo-esc 250 mg/L AACHAX 18,798,80 | |||||||||
| NFPA 704 |
|
Hygromycin B price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 10843555001 | Hygromycin B from Streptomyces hygroscopicus | 31282-04-9 | 20ml | $312 | 2024-03-01 | Buy |
| Sigma-Aldrich | 400050 | Hygromycin B, Streptomyces sp., Cell Culture-Tested - CAS 31282-04-9 - Calbiochem Unique aminoglycoside antibiotic that inhibits the growth of prokaryotic (bacteria) and eukaryotic microorganisms (yeasts) and mammalian cells. | 31282-04-9 | 1G | $348 | 2022-05-15 | Buy |
| Sigma-Aldrich | 400050 | Hygromycin B, Streptomyces sp., Cell Culture-Tested - CAS 31282-04-9 - Calbiochem Unique aminoglycoside antibiotic that inhibits the growth of prokaryotic (bacteria) and eukaryotic microorganisms (yeasts) and mammalian cells. | 31282-04-9 | 5G | $1290 | 2022-05-15 | Buy |
| TCI Chemical | H1509 | Hygromycin B >80.0%(HPLC) | 31282-04-9 | 200mg | $52 | 2024-03-01 | Buy |
| TCI Chemical | H1509 | Hygromycin B >80.0%(HPLC) | 31282-04-9 | 1g | $176 | 2024-03-01 | Buy |
Hygromycin B Chemical Properties,Uses,Production
Description
Hygromycin B is an aminoglycoside antibiotic that has been found in S. hygroscopicus. It is active against E. coli (MIC = 150 μg/ml) and cytotoxic to both prokaryotic and eukaryotic cells via inhibition of protein synthesis. Hygromycin B has commonly been used in molecular and cell biology applications to select for transformed cells expressing the E. coli hygromycin resistance genes hyg or hph.
Chemical Properties
White to off-white lyophilized powder
Uses
Hygromycin B, a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome
Uses
antibacterial, anthelmintic; LD50 ip (rat) 63mg/Kg
Uses
Hygromycin B is a trisaccharide aminoglycoside with a terminal cyclitol produced by Streptomyces hygroscopicus, reported by researchers at Eli Lily in the early 1950s. Hygromycin B belongs to the destomycin family of aminoglycosides which contain a unique cyclic structure linking the terminal saccharide. Hygromycin B exhibits broad spectrum antibiotic and anthelmintic activity, and is used as a feed additive for swine and poultry. Hygromycin B inhibits polypeptide synthesis by binding peptidyl-tRNA and preventing translocation by Elongation Factor 2.
Uses
Hygromycin B is an aminoglycoside and a selective antibiotic agent for the hph gene. Hygromycin B inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S rib osome
Application
Hygromycin B was found in the culture broth of Streptomyces hygroscopicus by Lilly Research Laboratories in 1953, as a mixture with hygromycin A. It showed activity against a variety of gram-positive and gram-negative bacteria as well as fungi. Hygromycin B has been used for therapy of helminthic infections in swine and poultry.
General Description
Amorphous solid or tan powder.
Air & Water Reactions
Water soluble.
Reactivity Profile
Weakly basic.
Fire Hazard
Flash point data for Hygromycin B are not available; however Hygromycin B is probably combustible.
Biochem/physiol Actions
Mode of Action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation. Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.
Safety Profile
Poison by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of Nox
storage
+4°C
References
[1] brodersen de, clemons wm jr, carter ap, et al. the structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin b on the 30s ribosomal subunit. cell, 2000, 103 (7): 1143-1154.
[2] ganoza mc, kiel mc. a ribosomal atpase is a target for hygromycin b inhibition on escherichia coli ribosomes. antimicrob agents chemother, 2001, 45 (10): 2813-2819.
Hygromycin B Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7378 | 58 |
| Wuhan Xinhao Biotechnology Co., Ltd | +86-18120578002 +86-18120578002 | xinhao-6@xinhaoshengwu.com | China | 350 | 58 |
| Shanghai Affida new material science and technology center | +undefined15081010295 | 2691956269@qq.com | China | 359 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 | sales@tianpharm.com | CHINA | 304 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
View Lastest Price from Hygromycin B manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-09 | Hygromycin B
31282-04-9
|
US $8.00-0.80 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2024-04-02 | hygromycin B solution from streptomyces hygroscopicus
31282-04-9
|
US $10.00-100.00 / kg | 1kg | 99% | 5000 Metric Ton/Month | Wuhan Xinhao Biotechnology Co., Ltd | |
 |
2024-03-19 | Hygromycin B
31282-04-9
|
US $0.00-0.00 / KG | 1KG | 99 | 50000KG/month | Shanghai Affida new material science and technology center |
-
- Hygromycin B
31282-04-9
- US $8.00-0.80 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- hygromycin B solution from streptomyces hygroscopicus
31282-04-9
- US $10.00-100.00 / kg
- 99%
- Wuhan Xinhao Biotechnology Co., Ltd
-
- Hygromycin B
31282-04-9
- US $0.00-0.00 / KG
- 99
- Shanghai Affida new material science and technology center