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ChemicalBook >> CAS DataBase List >>(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER Structure
(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER structure
CAS No.
72657-23-9
Chemical Name:
(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER
Synonyms
R-(-)-Roche Ester;(S)-Methyl 3-hydroxy-2-;(-)-Methyl 2-methylhydracrylate;METHYL D-(R)-3-HYDROXYISOBUTYRATE;(-)-methyl d-β-hydroxyisobutyrate;(R)-(-)-METHYL B-HYDROXYISOBUTYRATE;Methyle(R)-(-)-β-hydroxyisobutyrate;METHYL (R)-(-)-3-HYDROXYISOBUTYRATE;(-)-METHYL D-BETA-HYDROXYISOBUTYRATE;Methyl-D-(R)-beta-hydroxyisobutyrate
CBNumber:
CB9226746
Molecular Formula:
C5H10O3
Molecular Weight:
118.13
MDL Number:
MFCD00063450
MOL File:
72657-23-9.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:53
Product description Number Pack Size Price
Methyl (R)-(?)-3-hydroxy-2-methylpropionate 99% 270148 1g $39.83
Methyl (R)-(?)-3-hydroxy-2-methylpropionate 99% 270148 5g $144.44
Methyl (R)-(-)-3-Hydroxyisobutyrate >99.0%(GC) H0703 5g $141
Methyl (R)-(-)-3-Hydroxyisobutyrate >99.0%(GC) H0703 25g $470
(R)-3-HydroxyisobutyricAcidMethylEster H943558 2g $65
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(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER Properties

Boiling point 76-77 °C12 mm Hg(lit.)
Density 1.066 g/mL at 25 °C(lit.)
refractive index n20/D 1.425
Flash point 178 °F
storage temp. Sealed in dry,2-8°C
solubility Chloroform (Sparingly), Methanol (Slightly)
pka 14.40±0.10(Predicted)
form Liquid
color Clear colorless
optical activity [α]19/D −26°, c = 4 in methanol
BRN 3587507
InChI InChI=1S/C5H10O3/c1-4(3-6)5(7)8-2/h4,6H,3H2,1-2H3/t4-/m1/s1
InChIKey ATCCIZURPPEVIZ-SCSAIBSYSA-N
SMILES C(OC)(=O)[C@H](C)CO
CAS DataBase Reference 72657-23-9(CAS DataBase Reference)
FDA UNII 569FQ3X7KG
UNSPSC Code 12352108
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H227
Precautionary statements  P210-P280-P370+P378-P403+P235-P501
Risk Statements  10
Safety Statements  16
WGK Germany  3
HS Code  29181990
NFPA 704
2
0 0

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 270148 Methyl (R)-(?)-3-hydroxy-2-methylpropionate 99% 72657-23-9 1g $39.83 2025-07-31 Buy
Sigma-Aldrich 270148 Methyl (R)-(?)-3-hydroxy-2-methylpropionate 99% 72657-23-9 5g $144.44 2025-07-31 Buy
TCI Chemical H0703 Methyl (R)-(-)-3-Hydroxyisobutyrate >99.0%(GC) 72657-23-9 5g $141 2025-07-31 Buy
TCI Chemical H0703 Methyl (R)-(-)-3-Hydroxyisobutyrate >99.0%(GC) 72657-23-9 25g $470 2025-07-31 Buy
TRC H943558 (R)-3-HydroxyisobutyricAcidMethylEster 72657-23-9 2g $65 2021-12-16 Buy
Product number Packaging Price Buy
270148 1g $39.83 Buy
270148 5g $144.44 Buy
H0703 5g $141 Buy
H0703 25g $470 Buy
H943558 2g $65 Buy

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER Chemical Properties,Uses,Production

Chemical Properties

Clear Colorless Oil

Uses

The (R)- and (S)-isomers are bifunctional building blocks for the synthesis of a wide variety of optically active molecules.

Uses

Chiral derivative of 3-Hydroxyisobutyrate.

Synthesis

Methyl 2-(hydroxymethyl)acrylate

15484-46-5

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER

72657-23-9

GENERAL PROCEDURE: The general procedure for the synthesis of (-)-methyl-D-BETA-hydroxyisobutyrate from methyl 2-(hydroxymethyl)acrylate is as follows: the Ene-reductase activity assay needs to be carried out in anaerobic conditions (Coy Laboratory, Grass Lake, MI) at ambient temperature. Preparation of reaction stock solutions consisted of dissolving each substrate (see below for details) in 50 mM Tris-HCl buffer (pH 7.5) supplemented with 200 μM NADP+, 100 mM glucose, and glucose dehydrogenase (GDH) from Thermoplasma acidophilum (2 units were used for the IVTT reaction and 5 (2 units for the IVTT reaction and 5 units for the purified enzyme reaction). Individual substrate concentrations were selected to ensure that vmax conditions or maximum solubility were achieved. At these substrate concentrations, adjust reaction times to achieve 10-50% substrate conversion. For OYE activity assays in IVTT experiments, 20 μL of reaction stock solution was mixed with 2-10 μL of IVTT reaction mixture and the total assay volume was adjusted to 30 μL with 50 mM Tris-HCl (pH 7.5).For assays of purified OYE1 variants, the enzyme (final concentration: 250 nM) was added to 500 μL of reaction stock solution. The reaction process was quenched by removing a 30 μL aliquot from the assay solution and mixing it thoroughly with 30 μL of ethyl acetate containing 1 mM cyclohexanone (as internal standard). Organic phase samples were collected and analyzed by gas chromatography (GC) (see below for specific protocol). Enantiomeric/diastereoisomeric excesses were calculated by integrating the peak areas of the products and substrates. The relative conversion rate of each substrate was calculated by dividing the measured conversion rate of the OYE1 variant by the corresponding rate of wild-type OYE1.

References

[1] Advanced Synthesis and Catalysis, 2015, vol. 357, # 8, p. 1775 - 1786
[2] Tetrahedron Asymmetry, 2009, vol. 20, # 2, p. 210 - 213
[3] Angewandte Chemie - International Edition, 2009, vol. 48, # 12, p. 2162 - 2165
[4] Advanced Synthesis and Catalysis, 2008, vol. 350, # 16, p. 2533 - 2543
[5] Advanced Synthesis and Catalysis, 2010, vol. 352, # 14-15, p. 2663 - 2666

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Methyl 2-(hydroxymethyl)acrylate Propanoic acid, 3-[(4-methoxyphenyl)methoxy]-2-methyl-, methyl ester, (2R)- EC 1.1.1.47 Riboflavin 5'-Monophosphate Sodium Salt Triphosphopyridine nucleotide
DEXTROSE

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Preparation Products

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER Suppliers

Global( 222)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29734 60
Zjartschem 		+86-571 87238903 jocelynpan@zjarts.com CHINA 988 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29852 58
TianYuan Pharmaceutical CO.,LTD 		+86-755-23284190 13684996853 sales@tianpharm.com CHINA 304 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Shanghai Worldyang Chemical Co.,Ltd. 		+86-021-56795779 +8613651600618 sales@worldyachem.com China 1348 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9636 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 12071 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Zjartschem 		58
career henan chemical co 		58
TianYuan Pharmaceutical CO.,LTD 		58
Changzhou Ansciep Chemical Co., Ltd. 		58
Accela ChemBio Inc. 		58
Shanghai Worldyang Chemical Co.,Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Antai Fine Chemical Technology Co.,Limited 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58

View Lastest Price from (R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER pictures 2025-04-04 (R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER
72657-23-9
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
(R)-(-)-3-Hydroxy-2-Methylpropionic Acid Methyl Ester pictures 2022-02-25 (R)-(-)-3-Hydroxy-2-Methylpropionic Acid Methyl Ester
72657-23-9
 US $6.20 / KG 1KG 98% 10KG Hong Kong Tiansheng New Material Trading Co., Ltd
(R)-Roche ester pictures 2022-02-25 (R)-Roche ester
72657-23-9
 US $6.20 / KG 1KG 99% 10kg Hong Kong Tiansheng New Material Trading Co., Ltd
  • (R)-Roche ester pictures
  • (R)-Roche ester
    72657-23-9
  • US $6.20 / KG
  • 99%
  • Hong Kong Tiansheng New Material Trading Co., Ltd

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER Spectrum

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER(72657-23-9)MS(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER(72657-23-9)1HNMR(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER(72657-23-9)13CNMR(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER(72657-23-9)IR1(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER(72657-23-9)Raman

72657-23-9((R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER)Related Search:

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Diethyl bis(hydroxymethyl)malonate Triethyl methanetricarboxylate TETRAETHYL 1,1,2,2-ETHANETETRACARBOXYLATE DIETHYL DIALLYLMALONATE Dimethyl diethylmalonate
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(R)-(-)-3-HYDROXYISOBUTYRIC ACID METHYL ESTER (R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER (R)-(-)-METHYL B-HYDROXYISOBUTYRATE (R)-(-)-METHYL 3-HYDROXY-2-METHYLPROPIONATE [R]-[-]-METHYL 3-HYDROXY-2-METHYL-PROPIONATE D(-)-BETA-HYDROXYISOBUTYRIC ACID METHYL ESTER D-(R)-(-)-3-HYDROXYISOBUTYRIC ACID METHYL ESTER METHYL D-(R)-3-HYDROXYISOBUTYRATE (R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ES (R)-(-)-3-Hydroxyisobutyric Acid Methyl Ester (R)-(-)-3-Hydroxy-2-methylpropionic Acid Methyl Ester Methyl (R)-(-)-3-Hydroxy-2-methylpropionate Methyl (R)-(-)-beta-hydroxyisobutyrate, 98% (R)-(-)-METHYL 3-HYDROXY-2-METHYLPROPION (R)-(-)-3-Hydroxy-2-Methylpropionic acid Methyl ester, ee: 98% Methyl (R)-(-)-3-hydroxy-2-Methylpropionate 99% (R)-(-)-Methyl 3-hydroxy-2-methylpropionate for synthesis Methyle(R)-(-)-β-hydroxyisobutyrate (-)-METHYL D-BETA-HYDROXYISOBUTYRATE METHYL (R)-(-)-3-HYDROXY-2-METHYLPROPIONATE METHYL (R)-3-HYDROXY-2-METHYLPROPIONATE METHYL (R)-(-)-3-HYDROXYISOBUTYRATE (R)-(-)-3-hydroxy-2-methylpropionic*acid methyl E Propanoic acid, 3-hydroxy-2-methyl-, methyl ester, (2R)- (-)-methyl d-β-hydroxyisobutyrate Methyl (2R)-3-hydroxy-2-methyl-propanoate Methyl-D-(R)-beta-hydroxyisobutyrate METHYL (R)-(-)-3-HYDROXY-2-METHYL-PROPIO NATE, 99% (99% EE/GLC) (R)-(-)-3-HYDROXY-2-METHYLPROPIONIC*ACID METHYL EST (2R)-3-Hydroxy-2-methylpropionic Acid Methyl Ester R-(-)-Roche Ester (-)-Methyl D-β-hydroxyisobutyrate, (R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester Methyl (R)-3-hydroxy-2-methylpropionate, (R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester (-)-Methyl 2-methylhydracrylate (2R)-2-Methyl-3-hydroxypropanoic acid methyl ester (2R)-2-Methyl-3-hydroxypropionic acid methyl ester (R)-2-Methyl-3-hydroxypropionic acid methyl ester (R)-Methyl 3-hydroxy-2-Methylpropanoate (R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester, 99%, ee: 98% 3-hydroxy-2-methyl-, methyl ester, (2R)-Propanoic acid (R)-(-)-3-Hydroxy-3-Hyroxyisobutyrate Methyl(R)-(-)-3-Hydroxyisobutyrate> (S)-Methyl 3-hydroxy-2- methyI (R)-3-hydroxy-2-methylpropanoate (R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester/72657-23-9 high purity Methyl (R)-3-hydroxy-2-methylpropanoate (-) - Methyl-D-BATA-hydroxyisobutyrate (R)-(-)-3-HYDROXY-2-METHYLPRO-PIONIC ACIDMETHY ESTER Methyl (R)-(?)-3-hydroxy-2-methylpropionate 72657-23-9 Building Blocks for Liquid Crystals Chiral Building Blocks Esters (Chiral) Chiral Compounds (Building Blocks for Liquid Crystals) Organic Building Blocks Esters Asymmetric Synthesis Aliphatics Chiral Reagents Building Blocks for Liquid Crystals