ChemicalBook >> CAS DataBase List >>Isatoic Anhydride

Isatoic Anhydride

CAS No.
118-48-9
Chemical Name:
Isatoic Anhydride
Synonyms
1H-BENZO[D][1,3]OXAZINE-2,4-DIONE;Isatoic;2-(carboxyamino)-benzoicacicyclicanhydride;BENZOXAZINEDIONE;4H-3,1-Benzoxazine-2,4(1H)-dione;1,2-Dihydro-3,1-benzoxazine-2,4-dione;4H-3;Isatoic Ac;4(1H)-dione;1-Benzoxazine-2
CBNumber:
CB9238051
Molecular Formula:
C8H5NO3
Molecular Weight:
163.13
MDL Number:
MFCD00006700
MOL File:
118-48-9.mol
MSDS File:
SDS
Last updated:2023-11-16 17:07:08

Isatoic Anhydride Properties

Melting point 233 °C (dec.) (lit.)
Boiling point 290.19°C (rough estimate)
Density 1,52 g/cm3
vapor density 5.6 (vs air)
refractive index 1.5510 (estimate)
Flash point 308 °C
storage temp. Store below +30°C.
solubility 0.3g/l
form Powder
pka 11.06±0.20(Predicted)
color Beige to brown
Water Solubility decomposes
Sensitive Moisture Sensitive
BRN 136786
LogP 0.978 (est)
CAS DataBase Reference 118-48-9(CAS DataBase Reference)
EWG's Food Scores 1-2
FDA UNII R8TFA74Y4U
NIST Chemistry Reference Isatoic anhydride(118-48-9)
EPA Substance Registry System 2H-3,1-Benzoxazine-2,4(1H)-dione (118-48-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H317-H319
Precautionary statements  P261-P264-P272-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36-43
Safety Statements  24-26-37
WGK Germany  1
RTECS  DM3100000
3
Autoignition Temperature >600 °C
TSCA  Yes
HS Code  29349990
Toxicity LD50 orally in Rabbit: > 6400 mg/kg LD50 dermal Rabbit > 2000 mg/kg
NFPA 704
1
2 1

Isatoic Anhydride price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I12808 Isatoic anhydride 96% 118-48-9 100g $42.8 2024-03-01 Buy
Sigma-Aldrich I12808 Isatoic anhydride 96% 118-48-9 500g $149 2024-03-01 Buy
Sigma-Aldrich 8.04784 Isatoic anhydride for synthesis 118-48-9 100g $73.2 2024-03-01 Buy
Sigma-Aldrich 8.04784 Isatoic anhydride for synthesis 118-48-9 500g $461 2023-01-07 Buy
TCI Chemical I0081 Isatoic Anhydride >98.0%(HPLC)(T) 118-48-9 25g $60 2024-03-01 Buy
Product number Packaging Price Buy
I12808 100g $42.8 Buy
I12808 500g $149 Buy
8.04784 100g $73.2 Buy
8.04784 500g $461 Buy
I0081 25g $60 Buy

Isatoic Anhydride Chemical Properties,Uses,Production

Synthesis

Isatoic Anhydride is synthesized from indole (9a) by stirring in a 4:1 mixture of  DMF/H2O for 16 h at room temperature. 
1 H NMR (DMSO-d6): δ11.73 (s, br., 1H),  7.92 (d, J = 7.8 Hz, 1H), 7.74 (t, J = 7.8 Hz, 1H), 7.26 (t, J = 7.8 Hz, 1H), 7.16 (d,  J = 7.8 Hz, 1H).

Chemical Properties

BEIGE TO BROWN POWDER

Uses

Isatoic anhydride is a potent inactivator of α-chymotrypsin and inactivates stoichiometrically. Isatoic Anhydride is an important compound in the preparation of serine protease inhibitors.

Preparation

Phosphorus tribromide (0.035 mol) was added to a solution of N-carbethoxy- or N-carbobenzoxy-anthranilic acid (0.1 mol;prepared by coupling anthranilic acid with the corresponding carbalkoxy chloride in the usual way) in anhydrous diethyl ether (100 mL). After 24 h at room temperature, isatoic anhydride had separated as a microcrystalline product. It was collected by filtration, washed with dry diethyl ether, and recrystallized from ethanol. Yield ca. 90%.

Definition

A bicyclic molecule composed of a benzene ring attached at the oand mpositions to a heterocyclic ring. It forms useful anthranilic acid derivatives by reaction with hydrogen.

Flammability and Explosibility

Non flammable

Purification Methods

Recrystallise it from EtOH or 95% EtOH (30mL/g) or dioxane (10mL/g) and dry it in a vacuum. [Wagner & Fegley Org Synth Coll Vol III 488 1955, Ben-Ishai & Katchalski J Am Chem Soc 74 3688 1952, UV: Zentmyer & Wagner J Org Chem 14 967 1949, Beilstein 27 II 299, 27III/IV 3330.]

32315-10-9
118-92-3
118-48-9
Synthesis of Isatoic Anhydride from Triphosgene and Anthranilic acid
Global( 440)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5990 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Anhui Royal Chemical Co., Ltd.
+86-25-86655873 +8613962173137 marketing@royal-chem.com China 535 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293 sales@sdzschem.com China 2931 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58

View Lastest Price from Isatoic Anhydride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Isatoic anhydride pictures 2024-03-29 Isatoic anhydride
118-48-9
US $2.00 / KG 1KG ≥99% 500mt/year Jinan Finer Chemical Co., Ltd
Isatoic Anhydride pictures 2023-11-16 Isatoic Anhydride
118-48-9
US $25.00-10.00 / kg 1kg 0.99 20 tons Hebei Yanxi Chemical Co., Ltd.
Isatoic Anhydride pictures 2023-09-08 Isatoic Anhydride
118-48-9
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
2,4-Dioxo-1,2-dihydro-4H-3,1-benzoxazine 4H-3,1-Benzoxazin-2,4-(1H)-dion 4H-3,1-Benzoxazin-2,4(1H)-dion Anthranilic acid, N-carboxy-, cyclic anhydride Benzoic acid, 2-(carboxyamino)-, cyclic anhydride Benzoicacid,2-(carboxyamino)-,cyclicanhydride Isato acid anhydride 1,2-dihydro-4h-3,1-benzoxazine-2,4-dione 1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2,4-DIONE 3,1-BENZOXAZINE-2,4(1H)-DIONE 2H-3,1-BENZOXAZINE-2,4(1H)-DIONE LABOTEST-BB LT00053651 ISATOLC ANHYDRIDE ISATOIC ANHYDRIDE ANTHRANILIC ACID N-CARBOXYLIC ACID ANHYDRIDE TIMTEC-BB SBB003928 N-CARBOXYANTHRANILIC ACID CYCLIC ANHYDRIDE 2H-3,1-benzoxazine-2,4(1H)-dio N-carboxyanthranilic acid anhydride 1,4-Dihydro-2H-3,1-benzoxazine-2,4-dione Isatoic anhydride,98% Isatoic anhydride, 98% 100GR 3,1-Benzoxazine-2,4(1H)-dione, Anthranilic acid N-carboxylic acid anhydride 1H-3,1-Benzoxazine-2,4-dione Isatoic acid anhydride isatoicacidanhydride Isatonicanhydride Isatosαureanhydrid n-carboxy-anthranilicacicyclicanhydride N-Carboxyanthranilicanbydride n-carboxyanthranilicanhydride 1H-Benz[d][1,3]oxazine-2,4-dione 2-(CarboxyaMino)benzoic Acid Cyclic Anhydride Isatoic Ac ISATOIC ANHYDRIDE FOR SYNTHESIS Isatoic anhydrate 1H-3,1-benzoxazine-2,4-quinone 1-Benzoxazine-2 4(1H)-dione 4H-3 IsatoicAnhydride> Isatin anhydride Isatoic anhydride, 97%, 1,2-Dihydro-3,1-benzoxazine-2,4-dione 2-(carboxyamino)-benzoicacicyclicanhydride 4H-3,1-Benzoxazine-2,4(1H)-dione 1H-BENZO[D][1,3]OXAZINE-2,4-DIONE BENZOXAZINEDIONE Isatoic Isatoic anhydride (6CI) Isatioc anhydride 118-48-9 C6H4C2HNO3 CC6H4NHCOO C8H5NO3 Organic Building Blocks Building Blocks Carbonyl Compounds