TENOVIN-1
- CAS No.
- 380315-80-0
- Chemical Name:
- TENOVIN-1
- Synonyms
- CS-571;TENOVIN-1;Tenovin-1, >=98%;TENOVIN-1 USP/EP/BP;TENOVIN-1;TENOVIN 1;N-[(4-acetaMidophenyl)carbaMothioyl]-4-tert-butylbenzaMide;N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide;Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-;N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide Tenovin 1;Tenovin 1 N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide
- CBNumber:
- CB92446962
- Molecular Formula:
- C20H23N3O2S
- Molecular Weight:
- 369.48
- MDL Number:
- MFCD02914760
- MOL File:
- 380315-80-0.mol
| Melting point | >180°C (Subl.) |
|---|---|
| Density | 1.238±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO (10 mg/ml with warming) |
| form | solid |
| pka | 9.09±0.70(Predicted) |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| FDA UNII | BIQ6AID2B7 |
TENOVIN-1 price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13085 | Tenovin-1 ≥98% | 380315-80-0 | 5mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 13085 | Tenovin-1 ≥98% | 380315-80-0 | 10mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 13085 | Tenovin-1 ≥98% | 380315-80-0 | 50mg | $254 | 2024-03-01 | Buy |
| Cayman Chemical | 13085 | Tenovin-1 ≥98% | 380315-80-0 | 100mg | $443 | 2024-03-01 | Buy |
| Tocris | 3365 | Tenovin-1 ≥99%(HPLC) | 380315-80-0 | 50 | $266 | 2021-12-16 | Buy |
TENOVIN-1 Chemical Properties,Uses,Production
Description
Tenovin-
Uses
Tenovin 1 is a sirtuin inhibitor.
Definition
ChEBI: N-[(4-acetamidoanilino)-sulfanylidenemethyl]-4-tert-butylbenzamide is a member of thioureas.
Biological Activity
p53 activator that protects against MDM2-mediated p53 degradation. Elevates levels of p53 and p21 CIP/WAF1 and induces expression from an endogenous p53-dependent promoter. Exhibits potent antiproliferative activity in vitro .
References
Lain et al. (2008), Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator; Cancer Cell, 13 454 Sonnemann et al. (2014), p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors; Br. J. Cancer 110 656 Nihal et al. (2014), SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis; Cell Cycle 13 632 Wilking et al. (2014), SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation; Arch. Biochem. Biophys. 563 94 Marx et al. (2018), The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing’s sarcoma cell line; New Drugs 36 396 Bang et al. (2019), Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes; Biomol. Ther. (Seoul) 27 283
TENOVIN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
