(±)-1-[(3R*,4R*)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
- CAS No.
- 217461-40-0
- Chemical Name:
- (±)-1-[(3R*,4R*)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
- Synonyms
- (±)-J 113397;(+/-)-J113397;(±)-1-[(3R*,4R*)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one;2H-Benzimidazol-2-one, 1-[(3R,4R)-1-(cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-, rel-
- CBNumber:
- CB92518618
- Molecular Formula:
- C24H37N3O2
- Molecular Weight:
- 399.57
- MDL Number:
- MFCD09971098
- MOL File:
- 217461-40-0.mol
(±)-1-[(3R*,4R*)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Tocris | 2598 | (+/-)-J113397 ≥98%(HPLC) | 217461-40-0 | 10 | $306 | 2021-12-16 | Buy |
Tocris | 2598 | (+/-)-J113397 ≥98%(HPLC) | 217461-40-0 | 50 | $1264 | 2021-12-16 | Buy |
TRC | J211040 | (+/-)-J113397 | 217461-40-0 | 50mg | $1155 | 2021-12-16 | Buy |
ApexBio Technology | B7119 | (±)-J113397 | 217461-40-0 | 50mg | $1857 | 2021-12-16 | Buy |
ApexBio Technology | B7119 | (±)-J113397 | 217461-40-0 | 10mg | $448 | 2021-12-16 | Buy |
(±)-1-[(3R*,4R*)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one Chemical Properties,Uses,Production
Uses
(+/-)-J 113397 is an analogue is a potent nociceptin/orphanin FQ receptor antagonist. Non-peptide ORL-1 receptor antagonist.
Biological Activity
(±)-j 113397 is a potent and selective non-peptidyl antagonist of orl1 receptor, with a ki value of 1.8 nm for cloned human orl1 [1].the orl1 receptor is a g protein-coupled. it is structurally related to the opioid receptors. the heptadecapeptide nociceptin/orphanin fq is the endogenous ligand [2].in cho-orl1 cells, nociceptinr/orphanin fq dose-dependently suppressed the accumulation of cyclic amp stimulated by forskolin with an ec value of 0.22 ± 0.011 nm. treatment with j-113397 at increasing concentration shifted the concentration-response curve of nociceptinr/orphanin fq to the right. data indicated that j-113397 inhibited the interaction between nociceptinr/orphanin fq and orl1 in a competitive manner [1].in a tail-flick test, an i.c.v. injection of nociceptinr/orphanin fq at 0.01-1 nmol or saline was given to mice. i.c.v. injection of saline did not obviously change the latency of tail-flick. nociceptinr/orphanin fq at doses of more than 0.1 nmol shortened the latency. at the high concentration, the effect of nociceptinr/orphanin fq reached a maximal decrease at 15 min after the injection of j-113397. the effect of nociceptinr/orphanin fq lasted for more than 60 min. j-113397 inhibited the shortening of mouse tail-flick latency induced by nociceptinr/orphanin fq dose-dependently. j-113397 at 30 mg/kg completely reversed the hyperalgesia elicited by nociceptinr/orphanin fq [1].
storage
Desiccate at RT
References
[1]. ozaki s, kawamoto h, itoh y, et al. in vitro and in vivo pharmacological characterization of j-113397, a potent and selective non-peptidyl orl1 receptor antagonist. european journal of pharmacology, 2000, 402(1): 45-53.
[2]. mollereau c, mouledous l. tissue distribution of the opioid receptor-like (orl1) receptor. peptides, 2000, 21(7): 907-917.
(±)-1-[(3R*,4R*)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
(±)-1-[(3R*,4R*)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4678 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11976 | 58 |
United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |