MPC3100
- CAS No.
- 958025-66-6
- Chemical Name:
- MPC3100
- Synonyms
- CS-215;MPC3100;(2S)-1-[4-[2-[6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]purin-9-yl]ethyl]piperidin-1-yl]-2-hydroxypropan-1-one;(2S)-1-[4-[2-[6-Amino-8-[(6-bromo-1,3-benzodioxol-5-yl)thio]-9H-purin-9-yl]ethyl]-1-piperidinyl]-2-hydroxy-1-propanone;1-Propanone, 1-[4-[2-[6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)thio]-9H-purin-9-yl]ethyl]-1-piperidinyl]-2-hydroxy-, (2S)-
- CBNumber:
- CB92570377
- Molecular Formula:
- C22H25BrN6O4S
- Molecular Weight:
- 549.44
- MDL Number:
- MFCD22056121
- MOL File:
- 958025-66-6.mol
| Boiling point | 772.4±70.0 °C(Predicted) |
|---|---|
| Density | 1.77±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 13.95±0.20(Predicted) |
| FDA UNII | 9UMA2EEO9Q |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
MPC3100 price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22496 | MPC-3100 | 958025-66-6 | 1mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 22496 | MPC-3100 | 958025-66-6 | 5mg | $298 | 2024-03-01 | Buy |
| Cayman Chemical | 22496 | MPC-3100 | 958025-66-6 | 10mg | $435 | 2024-03-01 | Buy |
| Cayman Chemical | 22496 | MPC-3100 | 958025-66-6 | 25mg | $987 | 2024-03-01 | Buy |
| Usbiological | 017383 | MPC-3100 | 958025-66-6 | 5mg | $602 | 2021-12-16 | Buy |
MPC3100 Chemical Properties,Uses,Production
Uses
MPC-3100 is a recently discovered fully synthetic purine-based Hsp90 Inhibitor exhibiting anticancer properties
Biological Activity
mpc-3100 is a purine-based inhibitor of hsp90 with ic50 value of 60nm [1].mpc-3100 targets the n-terminal atp-binding site of hsp90 and blocks the activity of atpase. in the her2-luciferase degradation assay, mpc-3100 reduces this client protein of hsp90 with ic50 value of 60nm. in hct-116 cell lines, mpc-3100 inhibits cell proliferation with ic50 value of 540nm. besides that, mpc-3100 shows a broad spectrum anti-proliferative activity against various cancer cell lines, such as nci-n87 and du-145. mpc-3100 also inhibits tumor growth in the nci-n87 gastric cancer xenograft mode. moreover, pk studies show that mpc-3100 displays a superior oral pk profile, good overall exposure and a reasonable hepatic clearance rate. phase i clinical studies demonstrate mpc-3100 is safe and tolerated when administered at doses below 600 mg per day [1].
References
[1] kim sh, bajji a, tangallapally r, markovitz b, trovato r, shenderovich m, baichwal v, bartel p, cimbora d, mckinnon r, robinson r, papac d, wettstein d, carlson r, yager km. discovery of (2s)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9h-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (mpc-3100), a purine-based hsp90 inhibitor. j med chem. 2012 sep 13;55(17):7480-501.
MPC3100 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10269 | 58 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1494 | 55 | |
| shanghai cooperpharm co.,LTD . | +86-021-58975553 | sales@cooperpharm.com | China | 1210 | 56 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| ShangHai YingYi Chemical Technology Co., Ltd. | 86-21-50700185 13764109623 | sale@inyelchem.com | China | 178 | 55 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2989 | 60 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Shanghai Changyu Medical Technology Co. Ltd. | +86-13301875428 | sales@changyuhe.com | China | 290 | 58 |
View Lastest Price from MPC3100 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![(2S)-1-[4-[2-[6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]purin-9-yl]ethyl]piperidin-1-yl]-2-hydroxypropan-1-one pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/a2ecd9cb-dcf5-4e75-bad0-0780a9cc9d0e.png) |
2020-01-13 | (2S)-1-[4-[2-[6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]purin-9-yl]ethyl]piperidin-1-yl]-2-hydroxypropan-1-one
958025-66-6
|
US $1.00 / g | 1g | 99% | 1ton | Career Henan Chemical Co |
-
- (2S)-1-[4-[2-[6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]purin-9-yl]ethyl]piperidin-1-yl]-2-hydroxypropan-1-one
958025-66-6
- US $1.00 / g
- 99%
- Career Henan Chemical Co