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Voriconazole-d3

Voriconazole-d3 Structure
Voriconazole-d3 structure
CAS No.
188416-29-7
Chemical Name:
Voriconazole-d3
Synonyms
3R)-2-(2;VORICONAZOLE-D3;Voriconazole PI-6;(2R,3R)-Voriconazole;Voriconazole Intermediate II;4-triazol-1-yl)-2-butanol (RaceMic Voriconazole);4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1;(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol;(2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol;(2S,3R)-rel-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
CBNumber:
CB92610550
Molecular Formula:
C16H14F3N5O
Molecular Weight:
349.31
MDL Number:
MFCD09263753
MOL File:
188416-29-7.mol
Last updated:2023-06-01 14:25:53
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Voriconazole-d3 Properties

Boiling point 508.6±60.0 °C(Predicted)
Density 1.42±0.1 g/cm3(Predicted)
pka 11.54±0.29(Predicted)
FDA UNII USG4B1CD29

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Voriconazole-d3 price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17803 Voriconazole-d3 ≥99% deuterated forms (d1-d3) 500 μg $175 2023-06-20 Buy
Cayman Chemical 17803 Voriconazole-d3 ≥99% deuterated forms (d1-d3) 1 mg $306 2023-06-20 Buy
TRC V759995 (±)-Voriconazole 188416-29-7 500mg $375 2021-12-16 Buy
American Custom Chemicals Corporation HCH0344808 (2R,3S,2S,3R)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUORO-4-PYRIMIDINYL)-1-(1H-1,2,4-TRIAZOL-1-YL)-2-BUTANOL 95.00% 188416-29-7 5MG $496.38 2021-12-16 Buy
Matrix Scientific 100266 (2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 95+% 188416-29-7 250mg $742 2021-12-16 Buy
Product number Packaging Price Buy
17803 500 μg $175 Buy
17803 1 mg $306 Buy
V759995 500mg $375 Buy
HCH0344808 5MG $496.38 Buy
100266 250mg $742 Buy

Voriconazole-d3 Chemical Properties,Uses,Production

Description

Voriconazole-d3 is an Ergosterol biosynthesis inhibitor and a labeled form of Voriconazole. This mono triazole antifungal agent inhibits the growth of Candida, Cryptococcus, and Aspergillus species. Studies suggest that Voriconazole-d3 can be synthesized by modifying the structure of fluconazole. This antifungal agent functions by inhibiting cytochrome P450 dependent 14-α-sterol demethylase, which is responsible for the biosynthesis of Ergosterol. Furthermore, Voriconazole-d3 inhibits fungal growth, cell wall thinning, and cell membrane degradation.

Uses

Voriconazole is a triazole antifungal agent used primarily in the treatment or prevention of aspergillosis and candidal infections. However, its therapy may cause transient, asymptomatic serum aminotransferase elevations, and it is also a well-known cause of acute drug-induced liver injury.

Application

Voriconazole-d3 is derived from 2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone, which is an antifungal activity, particularly toward Candida albicans and Candida parapsilosis.

References

1. Voriconazole (UK-109,496) inhibits the growth and alters the morphology of fluconazole-susceptible and -resistant Candida species DOI:10.1128/AAC.41.8.1840
Belanger, P., et al. 1997. Antimicrob. Agents Chemother. 41: 1840-1842. PMID: 9257776
2. In vitro activities of voriconazole (UK-109,496) and four other antifungal agents against 394 clinical isolates of Candida spp
Marco, F., et al. 1998. Antimicrob. Agents Chemother. 42: 161-163. PMID: 9449278
3. In vitro activity of the new triazole voriconazole (UK-109,496) against opportunistic filamentous and dimorphic fungi and common and emerging yeast pathogens
Espinel-Ingroff, A. 1998. J. Clin. Microbiol. 36: 198-202. PMID: 9431946

Voriconazole-d3 Preparation Products And Raw materials

Raw materials

Preparation Products

Voriconazole-d3 Suppliers

Global( 73)Suppliers
Supplier Tel Email Country ProdList Advantage
HAINAN POLY PHARMCEUTICAL CO. LTD
+86-0571-89385087 +8613616530509 ff@hnpoly.com China 118 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15932 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Jinan Shengqi pharmaceutical Co,Ltd 		86+18663751872 christine@shengqipharm.com CHINA 491 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
HubeiwidelychemicaltechnologyCo.,Ltd 		18627774460 faith@widelychemical.com CHINA 742 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shanghai Yingrui Biopharma Co.,Ltd 		21-33585366 export01@shyrchem.com CHINA 1320 58
Supplier Advantage
HAINAN POLY PHARMCEUTICAL CO. LTD
58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
career henan chemical co 		58
Jinan Shengqi pharmaceutical Co,Ltd 		58
Hubei Jusheng Technology Co.,Ltd. 		58
HubeiwidelychemicaltechnologyCo.,Ltd 		58
Chongqing Chemdad Co., Ltd 		58
Shanghai Yingrui Biopharma Co.,Ltd 		58

View Lastest Price from Voriconazole-d3 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Voriconazole Intermediate II pictures 2022-09-15 Voriconazole Intermediate II
188416-29-7
 US $30.00-28.00 / Kg 1Kg 99.0% up 50 tons per month Xinxiang Hongqi District Houyuan Trading Co.,Ltd
(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole) pictures 2019-07-06 (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole)
188416-29-7
 US $7.00 / KG 1KG 99% 100kg Career Henan Chemical Co

188416-29-7(Voriconazole-d3)Related Search:

4-Ethyl-5-fluoropyrimidine Voriconazole Impurity 16 Ethanone, 1-(3,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-Butanesulfonic acid, 4-hydroxy-, methyl ester Pyrimidine, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis[2,6-dichloro-5-fluoro- (9CI)
Pyrimidine, 4-bromo-6-(1-bromoethyl)-5-fluoro- 1,2,4-Triazole Voriconazole Impurity 53 Voriconazole (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
ent-Voriconazole FENOFIBRIC ACID ETHYL ESTER (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 4-Ethyl-5-fluoro-6-hydroxypyrimidine 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine
2-Chloro-2',4'-difluoroacetophenone

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(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole) (2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (2S,3R)-rel-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol Voriconazole PI-6 (2R,3R)-Voriconazole (R *, S *) 3- (5-fluoropyrimidin-4-yl) -2- (2,4-difluorophenyl) -1- (1H-1,2,4-triazol-1-yl ) -2-butanol (2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol 3R)-2-(2 4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1 4-triazol-1-yl)-2-butanol (RaceMic Voriconazole) (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole)ChemicalBook 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-rel- (2R, 3S/2S, 3R)-3-(5-Fluoropyrimidin-4-yl)-2-(2,4-difluorophyenyl)-1-(1H-1,2,4 triazol-1-yl) butan-2-ol {Racemic Voriconazole} VORICONAZOLE-D3 Voriconazole Intermediate II 188416-29-7