Voriconazole-d3
- CAS No.
- 188416-29-7
- Chemical Name:
- Voriconazole-d3
- Synonyms
- 3R)-2-(2;VORICONAZOLE-D3;Voriconazole PI-6;(2R,3R)-Voriconazole;Voriconazole Intermediate II;Intermediate 2 of voriconazole;4-triazol-1-yl)-2-butanol (RaceMic Voriconazole);4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1;(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol;(2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
- CBNumber:
- CB92610550
- Molecular Formula:
- C16H14F3N5O
- Molecular Weight:
- 349.31
- MDL Number:
- MFCD09263753
- MOL File:
- 188416-29-7.mol
Boiling point | 508.6±60.0 °C(Predicted) |
---|---|
Density | 1.42±0.1 g/cm3(Predicted) |
pka | 11.54±0.29(Predicted) |
FDA UNII | USG4B1CD29 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
Voriconazole-d3 price More Price(10)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 17803 | Voriconazole-d3 ≥99% deuterated forms (d1-d3) | 500 μg | $175 | 2023-06-20 | Buy | |
Cayman Chemical | 17803 | Voriconazole-d3 ≥99% deuterated forms (d1-d3) | 1 mg | $306 | 2023-06-20 | Buy | |
TRC | V759995 | (±)-Voriconazole | 188416-29-7 | 500mg | $375 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | HCH0344808 | (2R,3S,2S,3R)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUORO-4-PYRIMIDINYL)-1-(1H-1,2,4-TRIAZOL-1-YL)-2-BUTANOL 95.00% | 188416-29-7 | 5MG | $496.38 | 2021-12-16 | Buy |
Matrix Scientific | 100266 | (2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 95+% | 188416-29-7 | 250mg | $742 | 2021-12-16 | Buy |
Voriconazole-d3 Chemical Properties,Uses,Production
Description
Voriconazole-d3 is an Ergosterol biosynthesis inhibitor and a labeled form of Voriconazole. This mono triazole antifungal agent inhibits the growth of Candida, Cryptococcus, and Aspergillus species. Studies suggest that Voriconazole-d3 can be synthesized by modifying the structure of fluconazole. This antifungal agent functions by inhibiting cytochrome P450 dependent 14-α-sterol demethylase, which is responsible for the biosynthesis of Ergosterol. Furthermore, Voriconazole-d3 inhibits fungal growth, cell wall thinning, and cell membrane degradation.
Uses
Voriconazole is a triazole antifungal agent used primarily in the treatment or prevention of aspergillosis and candidal infections. However, its therapy may cause transient, asymptomatic serum aminotransferase elevations, and it is also a well-known cause of acute drug-induced liver injury.
Application
Voriconazole-d3 is derived from 2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone, which is an antifungal activity, particularly toward Candida albicans and Candida parapsilosis.
References
1. Voriconazole (UK-109,496) inhibits the growth and alters the morphology of fluconazole-susceptible and -resistant Candida species DOI:10.1128/AAC.41.8.1840
Belanger, P., et al. 1997. Antimicrob. Agents Chemother. 41: 1840-1842. PMID: 9257776
2. In vitro activities of voriconazole (UK-109,496) and four other antifungal agents against 394 clinical isolates of Candida spp
Marco, F., et al. 1998. Antimicrob. Agents Chemother. 42: 161-163. PMID: 9449278
3. In vitro activity of the new triazole voriconazole (UK-109,496) against opportunistic filamentous and dimorphic fungi and common and emerging yeast pathogens
Espinel-Ingroff, A. 1998. J. Clin. Microbiol. 36: 198-202. PMID: 9431946
Voriconazole-d3 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
HAINAN POLY PHARMCEUTICAL CO. LTD | +86-0571-89385087 +8613616530509 | ff@hnpoly.com | China | 118 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1320 | 58 |
View Lastest Price from Voriconazole-d3 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2022-09-15 | Voriconazole Intermediate II
188416-29-7
|
US $30.00-28.00 / Kg | 1Kg | 99.0% up | 50 tons per month | Xinxiang Hongqi District Houyuan Trading Co.,Ltd | ||
2019-07-06 | (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole)
188416-29-7
|
US $7.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
- Voriconazole Intermediate II
188416-29-7
- US $30.00-28.00 / Kg
- 99.0% up
- Xinxiang Hongqi District Houyuan Trading Co.,Ltd
- (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole)
188416-29-7
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
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