Magnolol | 528-43-8

Magnolol Properties

Melting point	101.5-102°
Boiling point	180°C/1mmHg(lit.)
Density	1.107±0.06 g/cm3(Predicted)
FEMA	4559 \| MAGNOLOL
storage temp.	Sealed in dry,2-8°C
solubility	ethanol: soluble1mg/mL
pka	9.49±0.43(Predicted)
color	White to Almost white
Odor	bitter
λmax	292nm(EtOH)(lit.)
JECFA Number	2023
Merck	14,5697
Stability	Light Sensitive
LogP	4.502 (est)
Substances Added to Food (formerly EAFUS)	MAGNOLOL
CAS DataBase Reference	528-43-8(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	001E35HGVF

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07,GHS09

Signal word

Danger

Hazard statements

H315-H318-H335-H411

Precautionary statements

P273-P280-P302+P352-P305+P351+P338+P310

Hazard Codes

N

Risk Statements

37/38-41-51/53

Safety Statements

26-39-61

RIDADR

UN 3077

WGK Germany

3

RTECS

DV5105500

HS Code

29072990

Toxicity

LD50 orl-mus: 2200 mg/kg BRXXAA #5135746

NFPA 704

	0
3		0

Magnolol price More Price(56)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0001289	Magnolol European Pharmacopoeia (EP) Reference Standard	528-43-8	y0001289	$220	2024-03-01	Buy
Sigma-Aldrich	PHL89317	Magnolol phyproof? Reference Substance	528-43-8	20mg	$344	2024-03-01	Buy
Sigma-Aldrich	M3445	Magnolol ≥95% (HPLC), from plant	528-43-8	10mg	$179	2024-03-01	Buy
TCI Chemical	D3971	5,5'-Diallyl-2,2'-dihydroxybiphenyl >98.0%(GC)	528-43-8	1g	$159	2024-03-01	Buy
TCI Chemical	D3971	5,5'-Diallyl-2,2'-dihydroxybiphenyl >98.0%(GC)	528-43-8	200mg	$54	2024-03-01	Buy

Product number	Packaging	Price	Buy
Y0001289	y0001289	$220	Buy
PHL89317	20mg	$344	Buy
M3445	10mg	$179	Buy
D3971	1g	$159	Buy
D3971	200mg	$54	Buy

Magnolol Chemical Properties,Uses,Production

Description

Magnolol is an organic compound belonging to lignan. It is a kind of bioactive compounds identified from the bark of the Magnolia officinalis or M. grandiflora. It has been supplemented to Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic disease. It can act on the GABA receptor in vitro as a strong allosteric modulator. It also has antifungal effect, anti- periodontal activity as well as many osteoblast-stimulating and osteoclast-inhibiting activities. It has also found that magnolol can also activate the cannabinoid (CB) receptors.

References

https://en.wikipedia.org/wiki/Magnolol
https://www.caymanchem.com/product/14233

Description

Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB₂ subtype (EC₅₀ = 3.28 μM; K_i = 1.44 μM) versus central CB₁ (EC₅₀ = 18.3 μM; K_i = 3.15 μM).

Chemical Properties

White or off-white powder

Uses

Magnolol is the bioactive phytochemicals found in Magnolia officinalis (1). Magnolol has been used to treat anxiety, cough, headache and allergies (2). It also inhibits tumor necrosis factor-a-*induced ICAM-1 expression in human lung epithelial cells.

Definition

ChEBI: Magnolol is a member of biphenyls.

Hazard

Moderately toxic by ingestion.

Biological Activity

Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively.

Mechanism of action

Magnolol (5,5’-diallyl-2,2’-dihydroxybiphenyl) is a polyphenolic binaphthalene compound and a structural isomer of honokiol. Both magnolol and honokiol are isolated from the stem bark of a traditional Chinese herbal medicine Magnolia officinalis, which has been used for management of nervous disturbance, abdominal distention or disorders, gastrointestinal food stagnancy, and coughing and dyspnea. Magnolol has showed a wide spectrum of beneficial activities, including anti-inflammation, antimicroorganism, antioxidation, antiangiogenesis, anticancer, neuroprotection, cardiovascular protection, and lipolysis activities.

Safety Profile

Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andirritating vapors.

in vitro

Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. Magnolol has a more potent enhancing effect on GABAA receptor alpha2 subunit. Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml.

in vivo

Magnolol (5-15 mg/kg, p.o.) significantly attenuates the phenotypic severity of dextran sulfate sodium (DSS)-induced colitis in mice. Magnolol (10, 15 mg/kg, p.o.) attenuates histopathological changes and myeloperoxidase activity in the colon of DSS-treated mice, decreases DSS-induced high levels of proinflammatory cytokines TNF-α, IL-1β and IL-6 in the colonic tissues. Magnolol (10 mg/kg, p.o.) also reverses abnormality of serum metabolome, and regulates tryptophan metabolic pathway in mice.

Magnolol synthesis

Synthesis of Magnolol from 1,1'-Biphenyl, 2,2'-bis(2-propen-1-yloxy)-

Magnolol Preparation Products And Raw materials

Raw materials

2-Naphthalenemethanol, decahydro-8-[(2'-hydroxy-5,5'-di-2-propen-1-yl[1,1'-biphenyl]-2-yl)oxy]-α,α,4a,8-tetramethyl-, (2R,4aR,8R,8aR)-

Preparation Products

Magnolol Suppliers

Global( 475)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changsha Staherb Natural Ingredients Co., Ltd.	+86-0731-84213302 +8618374838656	sales@staherb.cn	China	1025	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Wuhan Haorong Biotechnology Co.,ltd	+8618565342920	sales@chembj.net	China	269	58
BINBO BIOLOGICAL CO.,LTD	+8618629063126	info@binbobiological.com	China	290	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
Chengdu Greenpure Biopharma CO.,Ltd	18283602253	jancyzheng@gcgreenpure.com	China	952	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58

Supplier	Advantage
Changsha Staherb Natural Ingredients Co., Ltd.	58
Hebei Yanxi Chemical Co., Ltd.	58
Wuhan Haorong Biotechnology Co.,ltd	58
BINBO BIOLOGICAL CO.,LTD	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Zheyan Biotech Co., Ltd.	58
Chengdu Greenpure Biopharma CO.,Ltd	58
career henan chemical co	58
Chengdu Biopurify Phytochemicals Ltd.	58

View Lastest Price from Magnolol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-24	Magnolol 528-43-8	US $0.00-0.00 / kg	20kg	99%	200000	Wuhan Haorong Biotechnology Co.,Ltd
2024-04-23	magnolol 528-43-8	US $0.00-0.00 / kg	1kg	1%-98%	1000	Changsha Staherb Natural Ingredients Co., Ltd.
2024-04-23	magnolia bark extract magnolol 528-43-8	US $0.00-0.00 / kg	1kg	90%; 98% HPLC	1000kg	Changsha Staherb Natural Ingredients Co., Ltd.

Magnolol
528-43-8
US $0.00-0.00 / kg
99%
Wuhan Haorong Biotechnology Co.,Ltd

magnolol
528-43-8
US $0.00-0.00 / kg
1%-98%
Changsha Staherb Natural Ingredients Co., Ltd.

magnolia bark extract magnolol
528-43-8
US $0.00-0.00 / kg
90%; 98% HPLC
Changsha Staherb Natural Ingredients Co., Ltd.

Magnolol Spectrum

Magnolol(528-43-8)¹HNMR

528-43-8(Magnolol)Related Search:

Allyl chloride Diallylamine Diallyldisulfide Allyl bromide Sodium allylsulfonate

Allyl glycidyl ether MAGNOLIABARKEXTRACT Allylamine 2,2'-Biphenol 2-Phenylphenol

3,3'-Dimethylbiphenyl CUPRESSUFLAVONE TRIHYDRATE Honokiol Magnolia bark Extract Honokiol Magnolol 3-(3-Methylphenyl)prop-1-ene

3-ETHYLBIPHENYL Magnolol Bornul magnolol

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5,5'-DIALLYL-BIPHENYL-2,2'-DIOL 5,5'-DIALLYL-2,2'-BIPHENYLDIOL 5,5'-DIALLYL-2,2'-DIHYDROXYBIPHENYL HONOKIOL(P) MAGNOLOL(SH) 5',5-di-2-propenyl-(1,1'-Biphenyl)-2,2'-diol MAGNOLOL Magnolia officinalis Rehd.et Wils MAGNOLOL 98.0% BY HPLC Honokiol std. Magnolol std. 1’-Biphenyl)-2,2’-diol,5’,5-di-2-propenyl-(1 MAGNOLIABARKEXTRACT [1,1'-Biphenyl]-2,2'-diol,5,5'-di-2-propenyl- 2,2'-Bichavicol 2,2'-Biphenyldiol, 5,5'-diallyl- MAGNOLOL(P) Maglol Magnolol(2,2 -Bichavicol) 4,4'-Diallyl-2,2'-biphenol Magnolol, froM Houpoea officinalis [1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl- NSC 293099 MagnoliaofficinalisRehderetWilson Nano Liposomal Magnolol Magnolol, 98%, from Magnolia officinalis Rehder & E. H. Wilson Magnolol 528-43-8 Magnolol, ≥98%(HPLC) 4-diphenylphosphoryl-N,N-dimethyl-4,4-diphenyl-1-butanamine Magnolol 2%-98% Magnolol CRS 5,5'-Diallyl-2,2'-dihydroxybiphenyl> Magnolol USP/EP/BP Magnolol D10 Magnolol D6 5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol Magnolol Powder 5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol 528-43-8 5291-75-5 Herb extract Plant extract Nutritional Ingredients chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Inhibitors Honokiol natural product Aromatic Phenols Antifungal The group of Magnolia