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Rubitecan

CAS No.
91421-42-0
Chemical Name:
Rubitecan
Synonyms
9-NC;RFS 2000;Oratheci;orathecin;RUBITECAN;RUBETICAN;Rubitecane;9-NITRO-CPT;9-Nitrocamptothecin;Rubitecan USP/EP/BP
CBNumber:
CB9270138
Molecular Formula:
C20H15N3O6
Molecular Weight:
393.35
MDL Number:
MFCD06656294
MOL File:
91421-42-0.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:14

Rubitecan Properties

Melting point 182-186°C
alpha D23 +27° (c = 0.2 in CH3OH-CHCl3, 1:4)
Boiling point 816.3±65.0 °C(Predicted)
Density 1.63
Flash point 106℃
storage temp. Sealed in dry,Room Temperature
solubility DMSO, Chloroform, Methanol
form Solid
pka 11.16±0.20(Predicted)
color Yellow
Merck 14,8288
CAS DataBase Reference 91421-42-0(CAS DataBase Reference)
FDA UNII H19C446XXB
NCI Drug Dictionary Orathecin

SAFETY

Risk and Safety Statements

Safety Statements  24/25
WGK Germany  3
RTECS  UQ0493300
HS Code  29399990

Rubitecan price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich R3655 Rubitecan 91421-42-0 10mg $56.7 2024-03-01 Buy
Sigma-Aldrich R3655 Rubitecan 91421-42-0 50mg $225 2024-03-01 Buy
TCI Chemical N0822 9-Nitrocamptothecin >98.0%(HPLC) 91421-42-0 100mg $273 2024-03-01 Buy
Cayman Chemical 28956 Rubitecan 91421-42-0 10mg $49 2024-03-01 Buy
Cayman Chemical 28956 Rubitecan 91421-42-0 25mg $112 2024-03-01 Buy
Product number Packaging Price Buy
R3655 10mg $56.7 Buy
R3655 50mg $225 Buy
N0822 100mg $273 Buy
28956 10mg $49 Buy
28956 25mg $112 Buy

Rubitecan Chemical Properties,Uses,Production

Description

Rubitecan, marketed by Supergen as Orathecin, is a promising oral treatment for solid melanoma, prostate, breast, ovarian, and other cancers, as well as leukemia. It is a derivative of camptothecin, a topoisomerase inhibitor known from Chinese Traditional Medicine. It selectively targets the critical S-stage of cellular reproduction – particularly in acidic environments, as in many cancer cells – relaxing DNA supercoiling and generating lethal breaks in the DNA. Due to insolubility, its biological delivery mechanism is not yet effective, and it has not been approved for clinical use.

Reference

https://www.sciencedirect.com/topics/medicine-and-dentistry/rubitecan
https://en.wikipedia.org/wiki/Rubitecan
https://en.wikipedia.org/wiki/Topoisomerase_inhibitor
https://en.wikipedia.org/wiki/Camptothecin#cite_note-Y.Pommier_2003-14
https://www.ncbi.nlm.nih.gov/pubmed/1995300

Description

Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner. Rubitecan inhibits the growth of A121 ovarian and H460 lung cancer cells (IC50s = 4 and 2 nM, respectively). It also inhibits the growth of doxorubicin-susceptible and -resistant MCF-7 breast cancer cells (IC50s = 2 and 3 nM, respectively). Rubitecan (4 mg/kg twice per week) reduces tumor growth in a U937 leukemia mouse xenograft model.

Chemical Properties

Yellow Amorphous Powder

Uses

Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic.

Definition

ChEBI: A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.

Rubitecan Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 186)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd.
18017610038 zheyansh@163.com CHINA 3620 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083 scglp@glp-china.com CHINA 1824 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715 admin@nexconn.com China 7836 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897 sales@biopurify.com China 3424 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Shochem(Shanghai) Co.,Ltd
86-21-50800795 info@shochem.com CHINA 288 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58

View Lastest Price from Rubitecan manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Rubitecan pictures 2022-12-26 Rubitecan
91421-42-0
US $23.00 / kg 1kg 99% 1000kg Hebei Duling International Trade Co. LTD
Rubitecan pictures 2022-10-14 Rubitecan
91421-42-0
US $0.00-0.00 / KG 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
Rubitecan USP/EP/BP pictures 2021-07-03 Rubitecan USP/EP/BP
91421-42-0
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
  • Rubitecan pictures
  • Rubitecan
    91421-42-0
  • US $23.00 / kg
  • 99%
  • Hebei Duling International Trade Co. LTD
  • Rubitecan pictures
  • Rubitecan
    91421-42-0
  • US $0.00-0.00 / KG
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.
9-Nitrocamptothecin (Rubitecan) 9-Nitrocamptothecin RFS 2000 9-Nitrocellulose camptothecine 9-NITRO-CPT 9-NITRO-20(S)-CAMPTOTHECIN (4s)-4-ethyl-4-hydroxy-10-nitro-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione RUBETICAN RUBITECAN orathecin CAMPTOTHECIN, 9-NITRO-20(S)- Rubitecane (4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[346,7]indolizinol[1,2-b]quinoline-3, 14(4H,-12H)-dione 9-NC Oratheci Rubitecan (RFS 2000) 9-Nitrocamptothecin> 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-nitro-, (4S)- Rubitecan USP/EP/BP Camptothecin Impurity 13 CAMPTOTHECIN, 9-NITRO-20 91421-42-0 C20H15N3O6 Anti-cancer & immunity API Intermediates & Fine Chemicals Pharmaceuticals