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Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate

CAS No.
1195768-19-4
Chemical Name:
Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
Synonyms
DABRAFENIB INT;Dalafenib intermediate 3;Methyl 3-(2,6-difluorophenylsulfonaMido)-2-fluorobenzoate;Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate;methyl 3-(((2,6-difluorophenyl)sulfonyl)amino)-2-fluorobenzo...;Methyl 3-{[(2,6-difluorophenyl)sulfonyl]aMino}-2-fluorobenzoate;Benzoic acid, 3-[[(2,6-difluorophenyl)sulfonyl]amino]-2-fluoro-, methyl ester
CBNumber:
CB92703779
Molecular Formula:
C14H10F3NO4S
Molecular Weight:
345.29
MDL Number:
MFCD18447698
MOL File:
1195768-19-4.mol
Last updated:2023-12-06 15:43:30

Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate Properties

Boiling point 445.4±55.0 °C(Predicted)
Density 1.507±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka 6.68±0.10(Predicted)
form Solid
color White to Off-White
InChI InChI=1S/C14H10F3NO4S/c1-22-14(19)8-4-2-7-11(12(8)17)18-23(20,21)13-9(15)5-3-6-10(13)16/h2-7,18H,1H3
InChIKey COSCWKICERLCEK-UHFFFAOYSA-N
SMILES C(OC)(=O)C1=CC=CC(NS(C2=C(F)C=CC=C2F)(=O)=O)=C1F

Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AK Scientific 8353DN Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate 1195768-19-4 250mg $123 2021-12-16 Buy
Crysdot CD12174605 Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate 95+% 1195768-19-4 1g $248 2021-12-16 Buy
Crysdot CD12174605 Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate 95+% 1195768-19-4 5g $743 2021-12-16 Buy
Alichem 1195768194 Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate 1195768-19-4 5g $787.5 2021-12-16 Buy
Product number Packaging Price Buy
8353DN 250mg $123 Buy
CD12174605 1g $248 Buy
CD12174605 5g $743 Buy
1195768194 5g $787.5 Buy

Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate Chemical Properties,Uses,Production

Uses

Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate can be useful in the development of B-RafV600E inhibitors.

Synthesis

Methyl 3-amino-2-fluorobenzoate was charged to the reactor, followed by dichloromethane. The contents were stirred and cooled to ~15°C, and pyridine was added. After that, the reactor contents were adjusted to ~15°C, and adding 2,6-diflurorobenzenesulfonyl chloride was started via an addition funnel. The temperature during addition was kept at <25°C. After complete addition, the reactor contents were warmed to 20-25°C and held overnight. Ethyl acetate was added, and dichloromethane was removed by distillation. Once distillation was complete, the reaction mixture was diluted again with ethyl acetate (5 vol) and concentrated. Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate was obtained through further purification.Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate

storage

Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 85)Suppliers
Supplier Tel Email Country ProdList Advantage
Enki Biopharmaceuticals (Shanghai) Limited
+86-0086-2157680326 +8613916707528 yusu@enkibiopharma.com China 47 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11001 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14936 58
Fluoropharm Co., Ltd.
+8613336034509 sales@fluoropharm.com China 1290 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Anqing Chico Pharmaceutical Co., Ltd.
15380796838 chloewu@chicopharm.cn CHINA 341 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58

View Lastest Price from Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate pictures 2024-01-02 Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate
1195768-19-4
US $50.00-500.00 / kg 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
Methyl 3-{[(2,6-difluoropheyl)sulfonyl]amino}-2-fluorabenzoate pictures 2022-12-02 Methyl 3-{[(2,6-difluoropheyl)sulfonyl]amino}-2-fluorabenzoate
1195768-19-4
US $200.00 / g 10g 99% 1000t/month Hebei Best Biological Technology Co., Ltd
Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate pictures 2022-10-01 Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate
1195768-19-4
US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

1195768-19-4(Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate)Related Search:

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