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Quetiapine fumarate

Antipsychotics Chemical properties Uses

CAS No. 111974-72-2
Chemical Name: Quetiapine fumarate
Synonyms: SEROQUEL;ICI-204636;QuetiapineFamarate;QUETIAPINE FUMARATE;DIBENZOTHIAZEPINOHONEP;QUETIAPINE HEMIGUMARTE;QUETIAPINE HEMIFUMARATE;Quetiapine FuMarate API;QUETIAPINE HEMIFUMERATE;Quetiapine fuMarate USP
CBNumber: CB9270451
Molecular Formula: C46H54N6O8S2
Formula Weight: 883.09
MOL File: 111974-72-2.mol
Quetiapine fumarate Property
Melting point : 174-176°C
Fp : 9℃
storage temp. : -20°C Freezer
solubility : DMSO: >10mg/mL
color : white to off-white
CAS DataBase Reference: 111974-72-2(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : Xn,N,T,F
Risk Statements : 22-50/53-52/53-39/23/24/25-23/24/25-11
Safety Statements : 60-61-45-36/37-16
RIDADR : UN1230 - class 3 - PG 2 - Methanol, solution
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Quetiapine fumarate Chemical Properties,Usage,Production

Antipsychotics
Quetiapine fumarate is an antipsychotic, successfully developed by the AstraZeneca United States, it interacts with a variety of neurotransmitter receptors, in the brain, it displays high degree affinity for serotonin (5-HT2) receptor, and it is greater than dopamine D1 and D2 dopamine receptor affinity in the brain. Quetiapine also has high affinity for histamine H1 receptor and adrenergic α1 receptors, and low affinity for α2 receptors, but it basically displays no affinity for cholinergic muscarinic receptors or benzodiazepine receptors . It shows positive results in antipsychotic activity assays such as conditioned avoidance reflex . In clinical, it is mainly used in treatment for adults with severe depression, acute manic episodes of bipolar disorder and schizophrenia of different types . It is not only effective for the positive symptoms of schizophrenia, but also having a certain effect for negative symptoms . It can also alleviate affective symptoms associated with schizophrenia, such as depression, anxiety symptoms and cognitive deficits.
The above information is edited by the chemicalbook of Tian Ye.
Chemical properties
White crystalline powder.
Uses
A non-classical antipsychotics.
Chemical Properties
White Crystalline Solid
Uses
Used as an antipsychotic. Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties
Uses
antihypertensive adrenergic receptor blocking agent with selective alpha1- and nonselective beta-adrenergic receptor blocking actions in a single substance.
Quetiapine fumarate Preparation Products And Raw materials
Raw materials
Preparation Products
Quetiapine fumarate Suppliers      Global( 236)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd. 0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3230 55
Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd. 027-59262863 13277907145 QQ 3091977954
027-59420980 dh.luna@whdhwy.com China 1999 50
Shanghai JONLN Reagent Co., Ltd. 021-61552785
021-35122006 sales@shshiji.com China 10344 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96831 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15950 69
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 6041 61
TCI (Shanghai) Development Co., Ltd. 800-988-0390
021-67121385 sales@tcishanghai.com.cn China 22833 81
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078,021-50426030
86-021-50426522,50426273 sales@jingyan-chemical.com China 10094 60
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418
001-617-206-9595 sales@chemreagents.com United States 9946 62
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111974-72-2(Quetiapine fumarate)Related Search:
Sodium 4-aminosalicylate dihydrate Risperidone 1,9-Pyrazoloanthrone ABT 737 Fumaric acid 1-[2-(2-hydroxyethoxy)ethyl]piperazine 2HCL (intermediate of quetiapine fumarate) 1-hydroxyethoxyethylpiperazine (intermediate of quetiapine fumarate) 1-[2-(2-hydroxyethoxy)ethyl]piperazine (intermediate of quetiapine fumarate) 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Quetiapine fumarate
SEROQUEL QUETIAPINE FUMARATE QUETIAPINE HEMIFUMARATE 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate 111974-72-2 DIBENZOTHIAZEPINOHONEP ICI-204636 QUETIAPINE FUMARATE, 99+% Quetiapine Fumarate main intermediates C42H50N6O4S2C4H4O4 2C21H25N3O2SC4H4O4 Seroquel, ICI-204636, Dibenzothiazepinohonep QUETIAPINE HEMIGUMARTE C21H25N3O2S12C4H4O4 Active Pharmaceutical Ingredients C46H54N6O8S2 Antipsychotic Intermediates & Fine Chemicals Pharmaceuticals Quetiapine Quetiapine·0.5fumaric acid 2-[2-(4-{2-thia-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,9,11,13-heptaen-10-yl}piperazin-1-yl)ethoxy]ethan-1-ol Quetiapine fuMarate(Seroquel) 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol Bis[(2E)-2-Butenedioate] Quetiapine FuMarate API Quetiapine heMifuMarate salt QUETIAPINE HEMIFUMERATE API Quetiapine fuMarate USP 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol,(2E)-2-butenedioate (2:1) Quetiapine fumarate solution Quetiapine for system suitability Pharmaceutical raw materials bulk drug material QuetiapineFamarate Inhibitors Ethanol, 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-, (2E)-2-butenedioate (2:1) C21H25N3O2S05C4H4O4
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