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Quetiapine fumarate

Antipsychotics Chemical properties Uses
Quetiapine fumarate
Quetiapine fumarate
CAS No.
111974-72-2
Chemical Name:
Quetiapine fumarate
Synonyms
SEROQUEL;ICI-204636;QuetiapineFamarate;QUETIAPINE FUMARATE;DIBENZOTHIAZEPINOHONEP;QUETIAPINE HEMIGUMARTE;QUETIAPINE HEMIFUMARATE;Quetiapine FuMarate API;QUETIAPINE HEMIFUMERATE;Quetiapine fuMarate USP
CBNumber:
CB9270451
Molecular Formula:
C46H54N6O8S2
Formula Weight:
883.09
MOL File:
111974-72-2.mol

Quetiapine fumarate Properties

Melting point:
174-176°C
Flash point:
9℃
storage temp. 
-20°C Freezer
solubility 
DMSO: >10mg/mL
color 
white to off-white
CAS DataBase Reference
111974-72-2(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,N,T,F
Risk Statements  22-50/53-52/53-39/23/24/25-23/24/25-11
Safety Statements  60-61-45-36/37-16
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Quetiapine fumarate price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1592704 Quetiapine fumarate 111974-72-2 100mg $347.4 2017-11-08 Buy
Sigma-Aldrich PHR1856 Quetiapine fumarate Pharmaceutical Secondary Standard; Certified Reference Material 111974-72-2 1g $129 2017-11-08 Buy
Cayman Chemical 14152 Quetiapine (hemifumarate) ≥95% 111974-72-2 1g $25 2017-11-08 Buy
Cayman Chemical 14152 Quetiapine (hemifumarate) ≥95% 111974-72-2 5g $94 2017-11-08 Buy
Sigma-Aldrich Q3638 Quetiapine hemifumarate salt ≥98% (HPLC) 111974-72-2 10mg $67.8 2017-11-08 Buy

Quetiapine fumarate Chemical Properties,Uses,Production

Antipsychotics

Quetiapine fumarate is an antipsychotic, successfully developed by the AstraZeneca United States, it interacts with a variety of neurotransmitter receptors, in the brain, it displays high degree affinity for serotonin (5-HT2) receptor, and it is greater than dopamine D1 and D2 dopamine receptor affinity in the brain. Quetiapine also has high affinity for histamine H1 receptor and adrenergic α1 receptors, and low affinity for α2 receptors, but it basically displays no affinity for cholinergic muscarinic receptors or benzodiazepine receptors . It shows positive results in antipsychotic activity assays such as conditioned avoidance reflex . In clinical, it is mainly used in treatment for adults with severe depression, acute manic episodes of bipolar disorder and schizophrenia of different types . It is not only effective for the positive symptoms of schizophrenia, but also having a certain effect for negative symptoms . It can also alleviate affective symptoms associated with schizophrenia, such as depression, anxiety symptoms and cognitive deficits.
The above information is edited by the chemicalbook of Tian Ye.

Chemical properties

White crystalline powder.

Uses

A non-classical antipsychotics.

Chemical Properties

White Crystalline Solid

Uses

Used as an antipsychotic. Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties

Uses

antihypertensive adrenergic receptor blocking agent with selective alpha1- and nonselective beta-adrenergic receptor blocking actions in a single substance.

Quetiapine fumarate Preparation Products And Raw materials

Raw materials

Preparation Products


Quetiapine fumarate Suppliers

Global( 237)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 3291 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3230 55
Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd. 027-59262863 13277907145 QQ 3091977954
027-59420980 dh.luna@whdhwy.com China 1992 50
Shanghai JONLN Reagent Co., Ltd. 021-61552785
021-35122006 sales@shshiji.com China 10344 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96831 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15950 69
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 6035 61
TCI (Shanghai) Development Co., Ltd. 800-988-0390
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JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078,021-50426030
86-021-50426522,50426273 sales@jingyan-chemical.com China 10094 60
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418
001-617-206-9595 sales@chemreagents.com United States 9946 62

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