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4-PHENOXYPHENYLBORONIC ACID

4-PHENOXYPHENYLBORONIC ACID Structure
4-PHENOXYPHENYLBORONIC ACID structure
CAS No.
51067-38-0
Chemical Name:
4-PHENOXYPHENYLBORONIC ACID
Synonyms
EOS-61617;AKOS BRN-0132;RARECHEM AH PB 0260;TIMTEC-BB SBB003409;Ibrutinib Impurity 36;4-PHENOXYPHENYLBORONI;4-Boronodiphenyl ether;4-phenoxy-phenylboric acid;4-PHENOXYPHENYLBORONIC ACID;4-PHENOXYBENZENEBORONIC ACID
CBNumber:
CB9278200
Molecular Formula:
C12H11BO3
Molecular Weight:
214.02
MDL Number:
MFCD00093312
MOL File:
51067-38-0.mol
MSDS File:
SDS
Last updated:2024-04-08 13:48:25
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4-PHENOXYPHENYLBORONIC ACID Properties

Melting point 141-145 °C(lit.)
Boiling point 377.0±44.0 °C(Predicted)
Density 1.23±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Methanol
pka 8.76±0.10(Predicted)
form Crystalline Powder
color White to beige
InChI InChI=1S/C12H11BO3/c14-13(15)10-6-8-12(9-7-10)16-11-4-2-1-3-5-11/h1-9,14-15H
InChIKey KFXUHRXGLWUOJT-UHFFFAOYSA-N
SMILES B(C1=CC=C(OC2=CC=CC=C2)C=C1)(O)O
CAS DataBase Reference 51067-38-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  37/39-26
WGK Germany  3
HazardClass  IRRITANT
HS Code  29319090
NFPA 704
0
2 0

4-PHENOXYPHENYLBORONIC ACID price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 480142 4-Phenoxyphenylboronic acid ≥95.0% 51067-38-0 5g $49.14 2024-03-01 Buy
Sigma-Aldrich 480142 4-Phenoxyphenylboronic acid ≥95.0% 51067-38-0 25g $363 2023-06-20 Buy
TCI Chemical P1974 4-Phenoxyphenylboronic Acid (contains varying amounts of Anhydride) 51067-38-0 5g $57 2024-03-01 Buy
TCI Chemical P1974 4-Phenoxyphenylboronic Acid (contains varying amounts of Anhydride) 51067-38-0 25g $169 2024-03-01 Buy
Alfa Aesar H52950 4-Phenoxybenzeneboronic acid, 98% 51067-38-0 1g $31.65 2024-03-01 Buy
Product number Packaging Price Buy
480142 5g $49.14 Buy
480142 25g $363 Buy
P1974 5g $57 Buy
P1974 25g $169 Buy
H52950 1g $31.65 Buy

4-PHENOXYPHENYLBORONIC ACID Chemical Properties,Uses,Production

Chemical Properties

white to off-white powder and chunk

Uses

4-Phenoxyphenylboronic acid can be used as a reactant:

  • In the Suzuki-Miyaura coupling reaction to synthesize aryl derivatives via C-C bond formation by reacting with different aryl halides over a palladium catalyst.
  • To prepare 1-phenoxy-4-(trifluoromethyl)benzene via oxidative trifluoromethylation using Chan-Lam-type reaction conditions.
  • To synthesize evobrutinib, a potent Bruton′s tyrosine kinase (BTK) inhibitor.

Uses

4-Phenoxybenzeneboronic Acid is an intermediate used to prepare biphenyl derivatives of nitotrifluoromethoxybenzyloxydihydroimidazooxazines with antitubercular activity. It is also used in the synthesis of pyrrolo pyrimidines as potent inhibitors of Lck kinase.

Uses

suzuki reaction

Synthesis

4-Bromodiphenyl ether (100 g, 0.402 mol)Was dissolved in anhydrous THF (800 mL)Under nitrogen protection,Cooled to -78 ° C,N-butyllithium (n-BuLi) (177 mL, 0.442 mol)The temperature is kept below -65 ° C,After stirring for 1 h,Continue to maintain the temperature -60 ,Triisopropyl borate (90 g, 0.482 mol) was added dropwise,Slowly rose to 0 ° C, stir for 3 h.Water (300 mL) was added under ice bath overnight. The reaction solution was concentrated to remove the organic phase,With 12N concentrated hydrochloric acid pH adjusted to 1 ~ 2,Precipitation of solids,Filtration and drying gave 4-phenoxyphenylboronic acid (77 g, yield 90%).

4-PHENOXYPHENYLBORONIC ACID synthesis

5419-55-6
2050-47-7
7732-18-5
51067-38-0
Synthesis of 4-PHENOXYPHENYLBORONIC ACID from Triisopropyl borate and Bis(4-bromophenyl) ether and Water

4-PHENOXYPHENYLBORONIC ACID Preparation Products And Raw materials

Raw materials

4-Bromophenoxybenzene Trimethyl borate Tetrahydrofuran n-Butyllithium 2-BROMODIPHENYL ETHER

Preparation Products

4-(TRIFLUOROMETHYL)DIPHENYL ETHER 4-NITROPHENYL PHENYL ETHER 4-Phenoxyphenol Benzene, 1-bromo-2-fluoro-4-phenoxy- 5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine
1-Phenoxy-4-(2-propenyl)benzene

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4-PHENOXYPHENYLBORONIC ACID Suppliers

Global( 378)Suppliers
Supplier Tel Email Country ProdList Advantage
China Synchem Technology Co.,Ltd.
+86-0552-4929304 +86-18055277008 wangxuhui1985@126.com China 55 55
Hebei Maison Chemical Co.,Ltd.
+8615511852758 sales@maisonchem.com.cn China 484 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5993 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7332 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15371 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9353 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
Supplier Advantage
China Synchem Technology Co.,Ltd.
55
Hebei Maison Chemical Co.,Ltd.
58
Hebei Yanxi Chemical Co., Ltd. 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Shanghai Yingrui Biopharma Co., Ltd. 		60

View Lastest Price from 4-PHENOXYPHENYLBORONIC ACID manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-PHENOXYPHENYLBORONIC ACID pictures 2024-04-08 4-PHENOXYPHENYLBORONIC ACID
51067-38-0
 US $34.00-1.20 / kg 1kg 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
4-Phenoxyphenylboronic acid pictures 2023-12-28 4-Phenoxyphenylboronic acid
51067-38-0
 US $0.00-0.00 / kg 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd
4-PHENOXYPHENYLBORONIC ACID pictures 2023-09-06 4-PHENOXYPHENYLBORONIC ACID
51067-38-0
 US $40.00-40.00 / kg 1kg 0.99 10 tons Hebei Yanxi Chemical Co., Ltd.

4-PHENOXYPHENYLBORONIC ACID Spectrum

4-PHENOXYPHENYLBORONIC ACID(51067-38-0)IR

51067-38-0(4-PHENOXYPHENYLBORONIC ACID)Related Search:

4-PHENOXYBENZOIC ACID (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one 4''-PROPYL-3-FLUOROBIPHENYL-4-BORONIC ACID 3,4,5-Trifluorophenylboronic acid 4-Chloro-2-fluoro-3-methoxyphenylboronic acid
4-(Hydroxymethyl)phenylboronic acid 3-Carboxyphenylboronic acid 3-Tolylboronic acid 1-Methyl-4-pyrazole boronic acid pinacol ester Ibrutinib Impurity 24
Ibrutinib (S)-Ibrutinib (S)-3-Hydroxypiperidine Ibrutinib Dimer Impurity Ibrutinib Impurity 28
Ibrutinib Impurity 25 Acrylic anhydride 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine

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4-PHENOXYBENZENEBORONIC ACID 4-PHENOXYPHENYLBORONIC ACID AKOS BRN-0132 RARECHEM AH PB 0260 (P-PHENOXYPHENYL)BORONIC ACID TIMTEC-BB SBB003409 4-Phenoxybenzeneboronic acid 98% 4-Phenoxyphenylboronic acid,97% 4-Phenoxyphenylboronic acid ,98% 4-Phenoxyphenylboronic Acid (contains varying aMounts of Anhydride) 4-Phenoxyphenylboronic acid, 97% 1GR 4-Boronodiphenyl ether 4-Phenoxyphenylboronic acid >=95.0% EOS-61617 4-Phenoxyphenylboronic acid Ibrutinib Ibrutinib Impurity 36 4-Phenoxyphenylboronic acid, 98%, for synthesis Boronic acid, B-(4-phenoxyphenyl)- 4-PHENOXYPHENYLBORONI 4-phenoxy-phenylboric acid 51067-38-0 C12H11BO3 Aryl Boronic Acids Boronic Acids and Derivatives Organometallic Reagents blocks BoronicAcids Heterocyclic Compounds Aryl Organoborons Boronic Acids Boronic Acids and Derivatives Boronic Acids