(R)-(+)-1-(4-Methylphenyl)ethylamine
- CAS No.
- 4187-38-6
- Chemical Name:
- (R)-(+)-1-(4-Methylphenyl)ethylamine
- Synonyms
- Tolylethylamine;(R)-1-P-TOLYLETHANAMINE;Methyl phenyl-ethylamine;(+)-p,α-Dimethylbenzylamine;alpha,4-dimethylbenzylamine;(R)-1-(p-tolyl)ethan-1-amine;(R)-(+)-1-(P-TOLYL)ETHYLAMINE;(R)-(+)-A-(P-TOLYL)ETHYLAMINE;(R)-(+)-4-(1-AMINOETHYL)TOLUENE;(R)-alpha,p-Dimethylbenzylamine
- CBNumber:
- CB9311444
- Molecular Formula:
- C9H13N
- Molecular Weight:
- 135.21
- MDL Number:
- MFCD00145202
- MOL File:
- 4187-38-6.mol
- MSDS File:
- SDS
| Melting point | <-20°C |
|---|---|
| Boiling point | 205 °C (lit.) |
| alpha | 37 º (NEAT) |
| Density | 0.919 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 180 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 9.20±0.10(Predicted) |
| Specific Gravity | 0.919 |
| optical activity | [α]20/D +37°, neat |
| Sensitive | Air Sensitive |
| BRN | 3195425 |
| CAS DataBase Reference | 4187-38-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H312+H332-H314 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 20/21/22-34 | |||||||||
| Safety Statements | 16-26-27-36/37/39-45 | |||||||||
| RIDADR | UN 2619 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2921490090 | |||||||||
| NFPA 704 |
|
(R)-(+)-1-(4-Methylphenyl)ethylamine price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 726664 | (R)-(+)-α,4-Dimethylbenzylamine ChiPros | 4187-38-6 | 5g | $104 | 2024-03-01 | Buy |
| Sigma-Aldrich | 405248 | (R)-(+)-α,4-Dimethylbenzylamine 98% | 4187-38-6 | 1g | $122 | 2023-06-20 | Buy |
| TCI Chemical | T1380 | (R)-(+)-1-(p-Tolyl)ethylamine >98.0%(GC) | 4187-38-6 | 1mL | $99 | 2021-12-16 | Buy |
| Alfa Aesar | L16328 | (R)-(+)-1-(4-Methylphenyl)ethylamine, ChiPros 98+% ee 98% | 4187-38-6 | 5g | $71 | 2021-12-16 | Buy |
| Alfa Aesar | L16328 | (R)-(+)-1-(4-Methylphenyl)ethylamine, ChiPros 98+% ee 98% | 4187-38-6 | 1g | $34.9 | 2021-12-16 | Buy |
(R)-(+)-1-(4-Methylphenyl)ethylamine Chemical Properties,Uses,Production
Chemical Properties
Colorless to light yellow liquid
Uses
(R)-(+)-α,4-Dimethylbenzylamine can be used as a chiral salt of keto acid, employed in the solid-state photolysis studies of α-mesitylacetophenone derivatives.
Application
(R)-(+)-α,4-Dimethylbenzylamine reacts with 1,5-difluoro-2,4-dinitrobenzene (DFDNB) to form a chiral derivative reagent(CDR) via substitution of one fluorine atom.
General Description
(R)-(+)-α,4-Dimethylbenzylamine is a chiral amine.
Synthesis
(R)-(+)-1-(4-methylphenyl)ethylamine was synthesized via a series of chemical reactions with (R)-N-[1-(4-methylphenyl)ethyl]acetamide. The steps are as follows:
1 g of the compound obtained in the previous stage will be used. 2 g of n-butanol was added, 0.63 g of potassium hydroxide was added, and the temperature was raised to 100 ° C. After 24 hours of heat preservation, cool down to 10 to 20 ℃. After adding water and stirring for 0.5 hours, the mixture was allowed to stand for separation, and the organic layer was concentrated to n-butanol, and then subjected to vacuum distillation (80-100 ℃ packed column) to obtain (R)-1-(4-methylphenyl)ethylamine 0.63 g. The yield was 82%, the HPLC purity was 96.3%, and the enantiomer was 0.8%.
structure and hydrogen bonding
(R)-(+)-1-(4-Methylphenyl)ethylamine is a chiral molecule studied in the context of crystallographic analysis and optimization. Through X-ray diffraction analysis, the crystal structure of (R)-(+)-1-(4-Methylphenyl)ethylamine was determined, revealing the presence of a significant hydrogen bond between the amine group and one of the carbonyl groups. This hydrogen bond plays a crucial role in stabilizing the (R)-(+)-1-(4-Methylphenyl)ethylamine molecule, which is a recurring pattern observed in structurally similar compounds. Furthermore, the (S)-(+)-enantiomer of (R)-(+)-1-(4-Methylphenyl)ethylamine was synthesized using an enantiopure precursor, establishing an efficient method to obtain this desired form of the molecule.
(R)-(+)-1-(4-Methylphenyl)ethylamine Preparation Products And Raw materials
(R)-(+)-1-(4-Methylphenyl)ethylamine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Jinli Pharmaceutical Co.,Ltd | +86-21-57256005 +86-15921811235 | chang@shjlchem.com | China | 20 | 58 |
| Chengdu Feibo Pharm Technology Co., Ltd | 15982321820 | abby@arkpharm.com | CHINA | 3279 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Jinjiangchem Corporation | 512-50133713 | sales@jinjiangchem.com | CHINA | 1072 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
View Lastest Price from (R)-(+)-1-(4-Methylphenyl)ethylamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | (R)-(+)-1-(4-Methylphenyl)ethylamine
4187-38-6
|
US $3.00 / KG | 1KG | 98% | 200KG | Career Henan Chemical Co |
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- (R)-(+)-1-(4-Methylphenyl)ethylamine
4187-38-6
- US $3.00 / KG
- 98%
- Career Henan Chemical Co