GSK106 (hydrochloride)
- CAS No.
- 1652591-82-6
- Chemical Name:
- GSK106 (hydrochloride)
- Synonyms
- GSK106;GSK106 (hydrochloride);(3-Amino-1-piperidinyl)[2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzimidazol-6-yl]-methanone Hydrochloride
- CBNumber:
- CB93152622
- Molecular Formula:
- C24H28ClN5O
- Molecular Weight:
- 437.965
- MDL Number:
- MFCD33029315
- MOL File:
- 1652591-82-6.mol
GSK106 (hydrochloride) price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17490 | GSK106 (hydrochloride) ≥98% | 1652591-82-6 | 500μg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 17490 | GSK106 (hydrochloride) ≥98% | 1652591-82-6 | 1mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 17490 | GSK106 (hydrochloride) ≥98% | 1652591-82-6 | 5mg | $283 | 2024-03-01 | Buy |
| Cayman Chemical | 17490 | GSK106 (hydrochloride) ≥98% | 1652591-82-6 | 10mg | $494 | 2024-03-01 | Buy |
| TRC | G797390 | (3-Amino-1-piperidinyl)[2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzimidazol-6-yl]-methanoneHydrochloride | 1652591-82-6 | 5mg | $235 | 2021-12-16 | Buy |
GSK106 (hydrochloride) Chemical Properties,Uses,Production
Description
Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases. GSK106 is an inactive control for the selective PAD4 inhibitors, GSK484 and GSK199 . It does not inhibit PAD4 nor does it prevent the citrullination of PAD4 target proteins or the formation of neutrophil extracellular traps in mouse or human neutrophils (IC50s > 100 μM). See the Structural Genomics Consortium (SGC) website for more information on both GSK484 and GSK106.
Uses
(3-Amino-1-piperidinyl)[2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzimidazol-6-yl]-methanone Hydrochloride is structurally similar to (3-Amino-1-piperidinyl)[1-methyl-2-(1-methyl-1H-indol-2-yl)-1H-benzimidazol-5-yl]-methanone TFA Salt (G797395) and is suitable to use as a control to identify inhibitors for protein arginine deiminase 4 (PAD4).
GSK106 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
GSK106 (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4691 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4182 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2990 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |