ChemicalBook >> CAS DataBase List >>AZD0364
AZD0364
- CAS No.
- 2097416-76-5
- Chemical Name:
- AZD0364
- Synonyms
- CS-2696;AZD0364;ADZ0346;Tizaterkib;ERK2 inhibitor;AZD0364 (ATG-017);AZD-0364/Tizaterkib;AZD 0364;AZD0364;ERK2 INHIBITOR;inhibit,ERK,AZD0364,AZD 0364,Tizaterkib,Inhibitor,Extracellular signal regulated kinases;(R)-7-(3,4-Difluorobenzyl)-6-(methoxymethyl)-2-(5-methyl-2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-6,7-dihydroimidazo[1,2-a]pyrazin-8(5H)-one
- CBNumber:
- CB93379847
- Molecular Formula:
- C24H24F2N8O2
- Molecular Weight:
- 494.5
- MDL Number:
- MFCD31631580
- MOL File:
- 2097416-76-5.mol
Last updated:2023-09-20 16:43:00
| Boiling point | 716.0±70.0 °C(Predicted) |
|---|---|
| Density | 1.45±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:41.67(Max Conc. mg/mL);84.27(Max Conc. mM) DMF:25.0(Max Conc. mg/mL);50.56(Max Conc. mM) DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.01(Max Conc. mM) Ethanol:54.5(Max Conc. mg/mL);110.21(Max Conc. mM) |
| form | A crystalline solid |
| pka | 2?+-.0.10(Predicted) |
| FDA UNII | VO9KX45QIQ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
AZD0364 price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29827 | AZD 0364 | 2097416-76-5 | 1mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 29827 | AZD 0364 | 2097416-76-5 | 10mg | $672 | 2024-03-01 | Buy |
| Cayman Chemical | 29827 | AZD 0364 | 2097416-76-5 | 5mg | $410 | 2024-03-01 | Buy |
| ChemScene | CS-0042190 | AZD-0364 99.75% | 2097416-76-5 | 10mg | $480 | 2021-12-16 | Buy |
| Apolloscientific | BISN0049 | AZD0364 98% | 2097416-76-5 | 10mg | $617 | 2021-12-16 | Buy |
AZD0364 Chemical Properties,Uses,Production
Biological Activity
AZD0364 (ATG-017) is an ERK1/2 inhibitor with IC50 of 0.6 nM for ERK2.
in vitro
AZD0364 has high cellular activity against direct downstream substrates of the MAPK signaling pathway (as in BRAF.
in vivo
AZD0364 has good oral pharmacokinetics in various species. In a xenograft model, AZD0364 inhibited phosphorylated p90RSK1 in a concentration-dependent manner in tumors. AZD0634 induces tumor regression in a KRAS-mutated NSCLC Calu 6 xenograft model, in which AZD0634 can be safely and effectively administered in combination with selumetinib.
target
| Target | Value |
| ERK2 () | 0.6 nM |
AZD0364 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 59)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| CR Corporation Lomited | fred.wen@crcorporation.cn | CHINA | 12069 | 58 | |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Supplier | Advantage |
|---|---|
| ATK CHEMICAL COMPANY LIMITED | 60 |
| BOC Sciences | 58 |
| TargetMol Chemicals Inc. | 58 |
| Career Henan Chemica Co | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | 58 |
| CR Corporation Lomited | 58 |
| InvivoChem | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | 58 |
| LEAPCHEM CO., LTD. | 58 |
| Aladdin Scientific | 58 |
2097416-76-5(AZD0364)Related Search:
AZD0364
CS-2696
AZD 0364;AZD0364;ERK2 INHIBITOR
ERK2 inhibitor
ADZ0346
Imidazo[1,2-a]pyrazin-8(5H)-one, 7-[(3,4-difluorophenyl)methyl]-6,7-dihydro-6-(methoxymethyl)-2-[5-methyl-2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-, (6R)-
Tizaterkib
AZD-0364/Tizaterkib
AZD0364 (ATG-017)
inhibit,ERK,AZD0364,AZD 0364,Tizaterkib,Inhibitor,Extracellular signal regulated kinases
(R)-7-(3,4-Difluorobenzyl)-6-(methoxymethyl)-2-(5-methyl-2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-6,7-dihydroimidazo[1,2-a]pyrazin-8(5H)-one
2097416-76-5
C24H24F2N8O2
API