ChemicalBook >> CAS DataBase List >>CLASTO-LACTACYSTIN BETA-LACTONE
CLASTO-LACTACYSTIN BETA-LACTONE
- CAS No.
- 154226-60-5
- Chemical Name:
- CLASTO-LACTACYSTIN BETA-LACTONE
- Synonyms
- OMURALIDE;BETA-CLASTOLACTACYSTIN;Clasto-Lactacystin β-lactone;clasto-lactacystin β-lactone;Clasto-lactacystin (OMuralide);CLASTO-LACTACYSTIN BETA-LACTONE;LACTACYSTIN, CLASTO-, BETA-LACTONE;1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE;(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione;6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)-
- CBNumber:
- CB9352564
- Molecular Formula:
- C10H15NO4
- Molecular Weight:
- 213.23
- MDL Number:
- MFCD01076526
- MOL File:
- 154226-60-5.mol
- MSDS File:
- SDS
Last updated:2023-06-08 09:03:06
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 20/21/22-37/38-41-36/37/38-25 | |||||||||
| Safety Statements | 16-26-36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 2 | |||||||||
| NFPA 704 |
|
CLASTO-LACTACYSTIN BETA-LACTONE price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L7035 | clasto-Lactacystin β-lactone | 154226-60-5 | 0.1mg | $434 | 2024-03-01 | Buy |
| Sigma-Aldrich | 426102 | clasto-Lactacystinβ-Lactone-CAS154226-60-5-Calbiochem Ahighlyspecific,cell-permeable,andirreversible20Sproteasomeinhibitor. | 154226-60-5 | 100μg | $223.8 | 2024-03-01 | Buy |
| Cayman Chemical | 70988 | Clasto-Lactacystin β-lactone ≥95% | 154226-60-5 | 50μg | $65 | 2024-03-01 | Buy |
| Cayman Chemical | 70988 | Clasto-Lactacystin β-lactone ≥95% | 154226-60-5 | 100μg | $124 | 2024-03-01 | Buy |
| Cayman Chemical | 70988 | Clasto-Lactacystin β-lactone ≥95% | 154226-60-5 | 500μg | $488 | 2024-03-01 | Buy |
CLASTO-LACTACYSTIN BETA-LACTONE Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
clasto-Lactacystin beta-lactone is a 20S proteasome and cathepsin A inhibitor.
Uses
Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor.
Uses
A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.
Biological Activity
cell-permeable. a highly specific, potent and irreversible proteasome inhibitor. lactacystin (cat. no. 1709-200) acts as a precursor for clasto-lactacystin β-lactone and the latter compound is at least 10 times more active than the parent lactacystin
Biochem/physiol Actions
Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii?by acting in the N-threonine residue of the? β -type subunits.
Synthesis of CLASTO-LACTACYSTIN BETA-LACTONE from (3R,4S,5R)-4-HYDROXY-5-[(1S)-1-HYDROXY-2-METHYLPROPYL]-3-METHYL-2-PYRROLIDINONE-5-CARBOXYLIC ACID
CLASTO-LACTACYSTIN BETA-LACTONE Preparation Products And Raw materials
Raw materials
Preparation Products
CLASTO-LACTACYSTIN BETA-LACTONE Suppliers
Global( 59)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| ApexBio Technology LLC | +1-832-696-8203 | info@apexbt.com | United States | 477 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
154226-60-5(CLASTO-LACTACYSTIN BETA-LACTONE)Related Search:
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1of4
OMURALIDE
LACTACYSTIN, CLASTO-, BETA-LACTONE
BETA-CLASTOLACTACYSTIN
CLASTO-LACTACYSTIN BETA-LACTONE
1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE
clasto-lactacystin β-lactone
Clasto-lactacystin
(OMuralide)
(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)-
Clasto-Lactacystin β-lactone
154226-60-5
Calpain and Proteasome InhibitorsProteasome, Calpain and Lysosomal Proteases
InhibitorsProtease Inhibitors
Proteasome inhibitor
Proteasome inhibitorEnzyme Inhibitors by Enzyme
Intracellular Protein Degradation
Nitric Oxide and Cell Stress
P to
Protease Inhibitor Specificity Index
Proteasomes
ProteasomeInhibitors
Inhibitors