Scopolamine hydrobromide
- CAS No.
- 114-49-8
- Chemical Name:
- Scopolamine hydrobromide
- Synonyms
- HYOSCINE;HYOSCINE HYDROBROMIDE;triptone;ScopolaMine HBr Trihydrate;hysco;Hyosol;kwells;scopos;sereen;scopamin
- CBNumber:
- CB9363236
- Molecular Formula:
- C17H21NO4.BrH
- Molecular Weight:
- 384.26
- MDL Number:
- MFCD00012647
- MOL File:
- 114-49-8.mol
- MSDS File:
- SDS
| Melting point | 195-199 °C (dry matter)(lit.) |
|---|---|
| alpha | D25 -24 to -26° (c = 5, calculated on anhydrous basis) |
| storage temp. | Store at RT |
| solubility | H2O: 50 mg/mL |
| form | powder |
| color | white to off-white |
| InChI | InChI=1/C17H21NO4.BrH/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;1H/t11-,12-,13-,14+,15-,16+;/s3 |
| InChIKey | WTGQALLALWYDJH-MLRWSLNSNA-N |
| SMILES | [C@]12([H])O[C@@]1([H])[C@@]1([H])N(C)[C@]2([H])C[C@@H](OC(=O)[C@H](CO)C2C=CC=CC=2)C1.Br |&1:0,3,5,9,12,16,r| |
| FDA 21 CFR | 310.545 |
| CAS DataBase Reference | 114-49-8(CAS DataBase Reference) |
| FDA UNII | R3K67DRL3J |
| EPA Substance Registry System | Scopolamine hydrobromide (114-49-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 36 | |||||||||
| RIDADR | UN 1544 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YM4550000 | |||||||||
| F | 3-8 | |||||||||
| HS Code | 2939800000 | |||||||||
| Toxicity | LD50 in rats (mg/kg): 3800 s.c. (Stockhaus, Wick) | |||||||||
| NFPA 704 |
|
Scopolamine hydrobromide price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.05818 | Scopolamine Hydrobromide - CAS 114-49-8 - Calbiochem | 114-49-8 | 1G | $126 | 2024-03-01 | Buy |
| Cayman Chemical | 14108 | Scopolamine (hydrobromide) ≥95% | 114-49-8 | 1mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 14108 | Scopolamine (hydrobromide) ≥95% | 114-49-8 | 5mg | $355 | 2024-03-01 | Buy |
| Tocris | 1414 | Scopolamine Hydrobromide ≥99%(HPLC) | 114-49-8 | 1G | $87 | 2021-12-16 | Buy |
| Matrix Scientific | 102724 | (1S,2R)-9-Methyl-3-oxa-9- azatricyclo[3.3.1.0{2,4}]nonan-7-yl- (2S)-3-hydroxy-2-phenylpropanoate trihydrate hydrobromide >95% | 114-49-8 | 1g | $102 | 2021-12-16 | Buy |
Scopolamine hydrobromide Chemical Properties,Uses,Production
Description
Scopolamine is a tropane alkaloid that can be found in many plants of the Solanaceae (nightshade) family. It is a muscarinic receptor antagonist that can be used to induce memory impairment in animals. Scopolamine prevents motion sickness, nausea, and vomiting in animals.
Chemical Properties
Off-White Solid
Uses
An acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicant
Definition
ChEBI: A hydrobromide that is obtained by reaction of scopolamine with hydrogen bromide.
brand name
Isopto Hyoscine (Alcon); Transderm-Scop (Ciba-Geigy).
General Description
Scopolamine hydrobromide(hyoscine hydrobromide) occurs as white orcolorless crystals or as a white, granular powder. It is odorlessand tends to effloresce in dry air. It is freely soluble inwater (1:1.5), soluble in alcohol (1:20), only slightly solublein chloroform, and insoluble in ether.
Scopolamine is a competitive blocking agent of theparasympathetic nervous system as is atropine, but it differsmarkedly from atropine in its action on the higher nervecenters. Both drugs readily cross the blood-brain barrierand, even at therapeutic doses, cause confusion, particularlyin the elderly.
General Description
Colorless crystals or white powder or solid. Has no odor. pH (of 5% solution): 4-5.5. Slightly efflorescent in dry air. Bitter, acrid taste.
Air & Water Reactions
Sensitive to air, light and moisture. Water soluble.
Reactivity Profile
Scopolamine hydrobromide is incompatible with acids, bases and oxidizing agents. .
Fire Hazard
Flash point data for Scopolamine hydrobromide are not available; however, Scopolamine hydrobromide is probably combustible.
Biological Activity
Non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.
Clinical Use
A sufficiently large dose of scopolamine will cause an individualto sink into a restful, dreamless sleep for about8 hours, followed by a period of approximately the samelength in which the patient is in a semiconscious state.During this time, the patient does not remember events thattake place. When scopolamine is administered with morphine,this temporary amnesia is termed twilight sleep.
Metabolism
Hyoscine hydrobromide is almost entirely metabolised, probably in the liver; only a small proportion of an oral dose is excreted unchanged in the urine. In one study in man, 3.4% of a single dose, administered by subcutaneous injection was excreted unchanged in urine within 72 hours.
storage
Store at RT
Purification Methods
The hydrobromide is recrystallised from Me2CO, H2O or EtOH/Et2O and dried. It is soluble in H2O (60%) and EtOH (5%) but insoluble in Et2O and slightly in CHCl3. The hydrochloride has m 300o (from Me2CO). The free base is a viscous liquid which forms a crystalline hydrate with m 59o and [] D 20 -28o (c 2.7, H2O). It hydrolyses in dilute acid or base. [Meinwald J Chem Soc 712 1953, Fodor Tetrahedron 1 86 1957, Beilstein 6 III 4185.]
Scopolamine hydrobromide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Lingding Biotechnology Co., Ltd. | +86-18031140164 +86-19933155420 | erin@hbldbiotech.com | China | 879 | 58 |
| Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 | evan@tyvovo.com | China | 150 | 58 |
| ARCTIC EXPORTS INC | +1-3026880818 +1-3026880818 | ARCTICEXPORTSINC@GMAIL.COM | Canada | 67 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
View Lastest Price from Scopolamine hydrobromide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-09 | Scopolamine hydrobromide; Flos?daturae extract
114-49-8
|
US $0.00 / KG | 1KG | 99% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2024-02-13 | Scopolamine
114-49-8
|
US $0.00 / kg | 10kg | 99% purity | 1000 kg | ARCTIC EXPORTS INC | |
 |
2023-09-14 | Scopolamine hydrobromide
114-49-8
|
US $69.00-3669.00 / g | 10g | 99% | 50tons | Wuhan Han Sheng New Material Technology Co.，Ltd |
-
- Scopolamine hydrobromide; Flos?daturae extract
114-49-8
- US $0.00 / KG
- 99% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Scopolamine
114-49-8
- US $0.00 / kg
- 99% purity
- ARCTIC EXPORTS INC
-
- Scopolamine hydrobromide
114-49-8
- US $69.00-3669.00 / g
- 99%
- Wuhan Han Sheng New Material Technology Co.，Ltd