Amlodipine | 88150-42-9

Amlodipine Properties

Melting point	178-179°C
Boiling point	527.2±50.0 °C(Predicted)
Density	1.227±0.06 g/cm3(Predicted)
RTECS	US7968329
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	Soluble in DMSO (up to 25 mg/ml), in DMF (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
pka	pKa 8.6 (Uncertain)
form	Almost white crystal powder
color	White
Water Solubility	75.3 mg/L
BCS Class	1
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference	88150-42-9(CAS DataBase Reference)
FDA UNII	1J444QC288
ATC code	C08CA01
EPA Substance Registry System	3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester (88150-42-9)

Pharmacokinetic data

Protein binding	>95%
Excreted unchanged in urine	<10%
Volume of distribution	20(L/kg)
Biological half-life	35-50 / 50

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS06,GHS08,GHS09

Signal word

Warning

Hazard statements

H301-H318-H373-H400-H410

Precautionary statements

P260-P280i-P301+P310a-P305+P351+P338-P405-P501a

HazardClass

IRRITANT

HazardClass

6.1

Toxicity

TDLo orl-chd: 400 mg/kg:BPR AJEMEN 18,581,2000

NFPA 704

	0
3		0

Amlodipine price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Alfa Aesar	J62242	Amlodipine, 97+%	88150-42-9	1g	$110.65	2024-03-01	Buy
Alfa Aesar	J62242	Amlodipine, 97+%	88150-42-9	5g	$420.65	2024-03-01	Buy
Cayman Chemical	14838	Amlodipine ≥98%	88150-42-9	1g	$109	2024-03-01	Buy
Cayman Chemical	14838	Amlodipine ≥98%	88150-42-9	5g	$401	2024-03-01	Buy
Alfa Aesar	J62242	Amlodipine, 97+%	88150-42-9	10g	$601.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
J62242	1g	$110.65	Buy
J62242	5g	$420.65	Buy
14838	1g	$109	Buy
14838	5g	$401	Buy
J62242	10g	$601.65	Buy

Amlodipine Chemical Properties,Uses,Production

Description

Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle. Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC₅₀ value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues. Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition in vitro and in vivo. Formulations containing amlodipine have been used in the treatment of hypertension.

Chemical Properties

Yellow Solid

Uses

A dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer.

Uses

anti-hypertensive;calcium channel blocker

Uses

A deuterated dihydropyridine calcium channel blocker.;Application of Labeled APIs: Labeled Amlodipine, intended for use as an internal standard for the quantification of Amlodipine by GC- or LC-mass spectrometry.

Definition

ChEBI: A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.

brand name

Norvasc (Pfizer).

General Description

Amlodipine, 2-[, for the treatment of hypertension. Amlodipineis also marketed as a combination therapy with atorvastatinunder the tradename Norvasc for the management of highcholesterol and high blood pressure.

Hazard

Human systemic effects.

Clinical Use

Calcium-channel blocker:
Hypertension
Angina prophylaxis

Safety Profile

Human systemic effects. Whenheated to decomposition it emits toxic vapors of NOx andCl^-.

Drug interactions

Potentially hazardous interactions with other drugs
Aminophylline and theophylline: possibly increased aminophylline and theophylline concentration.
Anaesthetics: enhanced hypotensive effect.
Antibacterials: metabolism possibly inhibited by clarithromycin, erythromycin and telithromycin.
Antidepressants: enhanced hypotensive effect with MAOIs, concentration possibly reduced by St John’s wort.
Antiepileptics: effects probably reduced by phenobarbital and primidone.
Antifungals: negative inotropic effect possibly increased with itraconazole.
Antihypertensives: enhanced hypotensive effect; increased risk of first dose hypotensive effect of postsynaptic alpha-blockers.
Antivirals: concentration increased by telaprevir and possibly by ritonavir - reduce dose of amlodipine.
Ciclosporin: ciclosporin concentration may be increased by up to 40%.
Lipid lowering agents: possibly increased risk of myopathy - do not exceed 20 mg of simvastatin.1 Tacrolimus: possibly increased tacrolimus levels.

Metabolism

Amlodipine is extensively metabolised by the liver to inactive metabolites with 10% of the parent compound and 60% of metabolites excreted in the urine.

References

1) Mason et al. (2003), Novel vascular biology of third-generation L-type calcium channel antagonists: ancillary actions of amlodipine; Arterioscler. Thromb. Vasc. Biol., 23 2155 2) Asano et al. (2003), A calcium channel blocker activates both ecto-5(‘)-nucleotidase and NO synthase in HUVEC; Biochem. Biophys. Res. Commun., 311 625 3) Yu et al. (2003), Amlodipine modulates THP-1 cell adhesion to vascular endothelium via inhibition of protein kinase C signal transduction; Hypertension, 42 329 4) Zhou et al. (2004), Inhibition of oxidative stress and improvement of endothelial function by amlodipine in angiotensin II-infused rats; Am. J. Hypertension, 17 167 5) Ueda et al. (1993), A comparative assessment of the duration of action of amlodipine and nifedipine GITS in normotensive subjects; Br. J. Clin. Pharmacol., 36 561

Amlodipine Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Chloroacetyl Monoethanolamine Methyl 3-aminocrotonate Maleic acid

PHENRAMINE MALEATE 2-Chlorobenzaldehyde

1of2

Preparation Products

Levamlodipine Besylate Amlodipine nicotinate

Amlodipine Suppliers

Global( 554)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15371	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +86-15064153060	alice@jndxj.com	China	309	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8822	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58

Supplier	Advantage
Anhui Ruihan Technology Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Biochempartner	58
Anhui Dexinjia Biopharm Co., Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
Hebei Guanlang Biotechnology Co., Ltd.	58
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58

View Lastest Price from Amlodipine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-02	Amlodipine 88150-42-9	US $0.00 / mg	10mg	0.98	10g	ShenZhen H&D Pharmaceutical Technology Co., LTD
2023-10-09	amlodipine 88150-42-9	US $0.00 / KG	1KG	0.99	500kg	Hebei Yanxi Chemical Co., Ltd.
2023-09-21	Amlodipine 88150-42-9	US $50.00 / kg	1kg	99%	10000tons	Anhui Ruihan Technology Co., Ltd

Amlodipine
88150-42-9
US $0.00 / mg
0.98
ShenZhen H&D Pharmaceutical Technology Co., LTD

amlodipine
88150-42-9
US $0.00 / KG
0.99
Hebei Yanxi Chemical Co., Ltd.

Amlodipine
88150-42-9
US $50.00 / kg
99%
Anhui Ruihan Technology Co., Ltd

Amlodipine Spectrum

Amlodipine(88150-42-9)¹HNMR

88150-42-9(Amlodipine)Related Search:

Methyl acrylate Ethyl formate Chromium picolinate Kresoxim-methyl Paraquat dichloride

Diethyl phthalate Acetonitrile Methylparaben Basic Violet 1 Urethane

2-Picolinic acid Methyl acetate Dihydromyrcenol Diethyl azodicarboxylate Triethyl orthoformate

acetic acid, triethoxy-, ethyl ester Methanol Levetiracetam

1of4

AMLODIPINE MM(CRM STANDARD) Amlodipine&Int AmlodipineBesylate/Maleate 3,5-Pyridinedicarboxylic acid, 2-(2-aminoethoxy)methyl-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester ethyl methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Pelmec Racemic Amlodipine 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2-((2-aminoethoxy)methyl)-4-(2-chlor 3-ethyl 5-methyl ester Amlodipine Besilate Imp.(EP) 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid O3-ethyl O5-methyl ester Amlodipine besilate (JAN) Amlodipine besylate (USAN) Isti O3-ethyl O5-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Amlodipine, >=99% (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 4-(2-chloro-phenyl-2(3-(1,3-dioxo-l,3-dihydro-isoindol-2yl-prpionyl)6-methyl-pyridin3, 5-dicarboxylic acid-ethyl-ethyl ester 5-methyl ester (p-2) of RS amlodipine besylate AMlodipine besylate, >95% Amlodipine Besylate IMP Amlodipine (base and/or unspecified salts) AMLODIPINE (BASE & SALTS) Amlodipine ( Amlodipine Benzenesulfonate) 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1，4-dihydro-3，5-pyridinedicarboxylic acid 5-methyl 3-ethyl ester UK-48340 UK-48340-11 2-(2-Aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl=5-methyl ester 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester AMLODIPINE methyl ethyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate LOTREL 3-ethyl5-methylester 2-Methyl-4-(2-chlorophenyl)-6-[[(2-aminoethyl)oxy]methyl]-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-ethyl ester 4-(2-Chlorophenyl)-2-methyl-6-(2-aminoethoxymethyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-ethyl ester 4-(2-Chlorophenyl)-6-methyl-2-(2-aminoethoxymethyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl 5-methyl ester 3-ethyl 5-Methyl (4S)-2-[(2-aMinoethoxy)Methyl]-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate AMlodipine(Norvasc) AMlodiping Besylate (R,S)-AMlodipine AMlopres Intervask 2-((2-Aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester AMLODIPINE (RS)-3-ETHYL-5-METHYL-2[(2-AMINOETHOXY)METHYL]-4-(2-CHLOROPHENYL)-6-METHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE 3,5-pyridinedicarboxylicacid,1,4-dihydro-2-((2-aminoethoxy)methyl)-4-(2-chlor (R)-3-ethyl 5-methyl 2 [2H4]-Amlodipine besylate odipine besyL Amlodipine Solution in Methanol, 100μg/mL Amlodipine USP/EP/BP Amlodipine (UK-48340 amlodipineQ: What is amlodipine Q: What is the CAS Number of amlodipine Q: What is the storage condition of amlodipine Q: What are the applications of amlodipine AMLODIPINE BASE Amlodipin besylate 3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate AMlodipine-d4 Maleate Amlodipine base (crystalline) phytoxanthin AmL