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D(+)-Galactosamine hydrochloride

D(+)-Galactosamine hydrochloride Structure
D(+)-Galactosamine hydrochloride structure
CAS No.
1772-03-8
Chemical Name:
D(+)-Galactosamine hydrochloride
Synonyms
Galactosamine;D-GALACTOSAMINE HYDROCHLORIDE;GALACTOSAMINE HCL;D-GALACTOSAMINE HCL;GALACTOSAMINE HYDROCHLORIDE;2-Amino-2-Deoxy-D-Galactopyranose;D-GALN HCL;CHONDROSAMINE;D-GalactosaMine HC1;D-CHONDROSAMINE HCL
CBNumber:
CB9386354
Molecular Formula:
C6H14ClNO5
Molecular Weight:
215.63
MDL Number:
MFCD00135830
MOL File:
1772-03-8.mol
MSDS File:
SDS
Last updated:2024-02-13 10:22:34
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D(+)-Galactosamine hydrochloride Properties

Melting point 182-185 °C (dec.)(lit.)
alpha 96 º (589nm c=1,H2O,24 hrs)
Density 1.3965 (rough estimate)
refractive index 96 ° (C=1, H2O)
storage temp. room temp
solubility H2O: 50 mg/mL, clear, colorless
form White solid
color White to Off-White
Water Solubility SOLUBLE
Sensitive Hygroscopic
Merck 14,4334
BRN 3697825
Stability Moisture Sensitive
CAS DataBase Reference 1772-03-8(CAS DataBase Reference)
FDA UNII U51H7Z9859
EPA Substance Registry System D-Galactose, 2-amino-2-deoxy-, hydrochloride (1772-03-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36/37/39-27-26
WGK Germany  3
RTECS  LW5500000
F  3-10
TSCA  Yes
HS Code  29329970
NFPA 704
1
0 0

D(+)-Galactosamine hydrochloride price More Price(60)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 34539-M D(+)Galactosamine, Hydrochloride - CAS 1772-03-8 - Calbiochem 1772-03-8 34539-1GM $92.2 2024-03-01 Buy
Sigma-Aldrich 1287722 Galactosamine hydrochloride United States Pharmacopeia (USP) Reference Standard 1772-03-8 50mg $536 2024-03-01 Buy
Sigma-Aldrich 34539-M D(+)Galactosamine, Hydrochloride - CAS 1772-03-8 - Calbiochem 1772-03-8 1G $71.7 2022-05-15 Buy
Alfa Aesar L07462 D-Galactosamine hydrochloride, 98% 1772-03-8 250mg $23.8 2021-12-16 Buy
Alfa Aesar L07462 D-Galactosamine hydrochloride, 98% 1772-03-8 1g $79.2 2021-12-16 Buy
Product number Packaging Price Buy
34539-M 34539-1GM $92.2 Buy
1287722 50mg $536 Buy
34539-M 1G $71.7 Buy
L07462 250mg $23.8 Buy
L07462 1g $79.2 Buy

D(+)-Galactosamine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Solid

Uses

D-(+)-Galactosamine hydrochloride has been used to:

  • induce livery injury
  • inflammatory liver injury
  • acute liver failure (ALF) in mice

Uses

D-(+)-Galactosamine (D-chondrosamine) is used with lipopolysaccharides (LPS) to induce models of acute hepatic failure (LPS/D-GalN-induced liver injury, hepatitis) for therapeutic research to find new drugs.

Uses

Specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Galactosamine (D-GalN) is synthesized from galactose and is potential hepatotoxic agent. D-GalN in combination with lipopolysaccharide leads to the development of lethal liver injury and hepatic failure. It sensitizes cells to the toxic effects of the cytokine in particular the tumor necrosis factor(TNF).

Synthesis

A preparation process of D-galactosamine hydrochloride, adding 500ml absolute ethanol into a 1000ml three-necked flask with a reflux condenser, a stirrer and a thermometer, stirring at room temperature and adding 100g of dimethyl dodecyl respectively Tetradecylamine and 500g of solid-supported silica were heated to 110°C within 30 minutes, kept in reflux for 5 hours and then lowered to 29°C, filtered and dried to obtain 589g of organic amine solid-supported catalyst. In a 1000ml three-necked flask with a stirrer and a thermometer, 190g of 5-methyltryptamine hydrochloride and 600ml of dimethylamide were respectively added, 59g of organic amine solid-supported catalyst and 150g of chloropropene were added, and the reaction was carried out for eight hours at room temperature. Liquid filtration, the obtained filtrate was evaporated to dryness and dissolved in 1150ml of isopropanol, and 89ml of 36wt% hydrochloric acid was added to hydrochloride to obtain 130.32g of white crystals of 2-amino-2-deoxy-D-galactose hydrochloride with a yield of 42.05%.

Purification Methods

Dissolve the hydrochloride in a small volume of H2O. Then add three volumes of EtOH, followed by acetone until faintly turbid and keep overnight in a refrigerator. [Roseman & Ludoweig J Am Chem Soc 76 301 1954, Beilstein 4 IV 2024.]

D(+)-Galactosamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

D(+)-Galactosamine hydrochloride Suppliers

Global( 486)Suppliers
Supplier Tel Email Country ProdList Advantage
Qingdao Dexin Chemical Co., Ltd 		+8615553333686 15553333686@qq.com China 2983 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5993 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Wuhan Haorong Biotechnology Co.,ltd 		+8618565342920 sales@chembj.net China 269 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3620 58
Supplier Advantage
Qingdao Dexin Chemical Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Wuhan Haorong Biotechnology Co.,ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Shanghai Zheyan Biotech Co., Ltd. 		58

View Lastest Price from D(+)-Galactosamine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
D(+)-Galactosamine hydrochloride pictures 2024-04-24 D(+)-Galactosamine hydrochloride
1772-03-8
 US $0.00-0.00 / kg 1kg 99% 2000 Wuhan Haorong Biotechnology Co.,Ltd
D(+)-Galactosamine HCl pictures 2024-02-13 D(+)-Galactosamine HCl
1772-03-8
 US $600.00 / g 1g 98 500 Kg R&D Scientific Inc.
D(+)-Galactosamine hydrochloride pictures 2023-11-14 D(+)-Galactosamine hydrochloride
1772-03-8
 US $0.00 / kg 1kg 0.99 20 tons Hebei Yanxi Chemical Co., Ltd.

D(+)-Galactosamine hydrochloride Spectrum

D(+)-Galactosamine hydrochloride(1772-03-8)1HNMRD(+)-Galactosamine hydrochloride(1772-03-8)13CNMRD(+)-Galactosamine hydrochloride(1772-03-8)IR1D(+)-Galactosamine hydrochloride(1772-03-8)IR2D(+)-Galactosamine hydrochloride(1772-03-8)Raman

1772-03-8(D(+)-Galactosamine hydrochloride)Related Search:

D-Galactose D-(+)-GALACTOSE 4-AMINOAZOBENZENE HYDROCHLORIDE D-Glucosamine hydrochloride Pectinase
Glycine Galacto-oligosaccharides ALTRENOGEST Topotecan hydrochloride D-GALACTOSE 1-[2-(2-AZIDOETHOXY)ETHOXYETHYL]-2,3,4,6-TETRA-O-ACETATE
6-Aminocaproic acid TRIGALACTURONIC ACID Tris(hydroxymethyl)aminomethane KANOSAMINE, HYDROCHLORIDE D-Mannosamine hydrochloride
C08349 Tryptamine 5-Bromo-4-chloro-3-indolyl-N-acetyl-beta-D-galactosaminide

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D-Galactosamine hydrochloride ,98.5% D(+)-GalactosaMine hydrochloride, 99% 1GR D(+)-GalactosaMine hydrochloride, 99% 5GR D(+)-GalatosaMine hydrochloride Galactosamine Hydrochloride (300 mg) D-GalactosaMine HC1 2-aMino-2-deoxy-L-idose (3R,4R,5R,6R)-3-aMino-6-(hydroxyMethyl)tetrahydro-2H-pyran-2,4,5-triol hydrochloride 2-[15N]aMino-2-deoxy-d-[1-13C] galactose hydrochloride 2-aMino-2-deoxy-galactose hydrochloride -D- Galactosamine Hydrochloride (50 mg) 2-amino-2-deoxy-D-galactose hydrochloride (1:1) 2-amino-2-deoxy-,hydrochloride,d-galactos 2-amino-2-deoxy-d-galactoshydrochloride D-Galactose, 2-amino-2-deoxy-, hydrochloride D-(+)-Galactosamine hydrochloride≥ 98% (Assay) 2-AMINO-2-DEOXY-D-GALACTOPYRANOSE HCL GALACTOSE,2-AMINO-2-DEOXY-,HYDROCHLORIDE,D- 2-Amino-2-deoxy-D-galactopyranose hydrochloride,D-Chondrosamine hydrochloride 2-AMINO-D-GALACTOSE HYDROCHLORIDE 2-AMINO-2-DEOXY-D-GALACTOPYRANOSE HYDROCHLORIDE 2-AMINO-2-DEOXY-D-GALACTOSE 2-AMINO-2-DEOXY-D-GALACTOSE HYDROCHLORIDE 2-AMINO-3-DEOXY-D-GALACTOSE HYDROCHLORIDE D-2-GALACTOSAMINE HYDROCHLORIDE D-CHONDROSAMINE HCL D-CHONDROSAMINE HYDROCHLORIDE D(+)-GALACTOSAMINE HYDROCHLORIDE D-GALN HCL CHONDROSAMINE CHONDROSAMINE HYDROCHLORIDE GALACTOSAMINE HCL, D- D(+)-GALACTOSAMINE HYDROCHLORIDE CELL*CU LTURE TESTE D-(+)-GALACTOSAMINE HYDROCHLORIDE, 98+% D-(+)-GALACTOSAMINE HYDROCHLORIDE, CELL CULTURE REAGENT 99% 2-Amino-2-deoxy-D-galactopyranosehydrochloride,D- D(+)Galactosamine hydrochloride D-Chondrosamine hydrochloride D-GALACTOSAMINE HYDROCHLORIDE extrapure 2-Amino-2-deoxy-D-galactopyranose hydrochloride, D-Chondrosamine hydrochloride, Chondrosamine (2R,3R,4R,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride D(+)-Galactosamine hydrochloride,99% D-Glactosamine Hydrochloride D-Galactosamine hydrochloride ,97% D(+)-Galactosamine h D-(+)-GalactosamineHydrochloride> D-Galactose, 2-amino-2-deoxy-, hydrochloride (1:1) Glucosamine Hydrochloride Impurity 9 D(+)-Galactosamine hydrochloride USP/EP/BP actosamine hydrochL D(+)Galactosamine, Hydrochloride - CAS 1772-03-8 - Calbiochem D-Galactosamine hydrochloride(Non-animal sources) Galactosamine D-GALACTOSAMINE HCL D-GALACTOSAMINE HYDROCHLORIDE GALACTOSAMINE HCL GALACTOSAMINE HYDROCHLORIDE 2-Amino-2-Deoxy-D-Galactopyranose D-galactose hydrochloride