Lorazepam
- CAS No.
- 846-49-1
- Chemical Name:
- Lorazepam
- Synonyms
- ATIVAN;(±)-Lorazepam solution;Lorazepam CIV (200 mg)I1D4040.998mg/mg(ai);7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one;Quait;Tavor;Wypax;LORAX;Wy-403;8133 CB
- CBNumber:
- CB9393402
- Molecular Formula:
- C15H10Cl2N2O2
- Molecular Weight:
- 321.16
- MDL Number:
- MFCD00063406
- MOL File:
- 846-49-1.mol
| Melting point | 166-168°C |
|---|---|
| Boiling point | 533.8±50.0 °C(Predicted) |
| Density | 1.4835 (rough estimate) |
| refractive index | 1.6070 (estimate) |
| Flash point | 11 °C |
| storage temp. | −20°C |
| solubility | Practically insoluble in water, sparingly soluble in ethanol (96 per cent), sparingly soluble or slightly soluble in methylene chloride. |
| pka | pK1 1.3; pK2 11.5(at 25℃) |
| Water Solubility | 54mg/L(temperature not stated) |
| BCS Class | 1 |
| Stability | hygroscopic |
| CAS DataBase Reference | 846-49-1(CAS DataBase Reference) |
| FDA UNII | O26FZP769L |
| NCI Dictionary of Cancer Terms | lorazepam |
| NCI Drug Dictionary | Ativan |
| ATC code | N05BA06,N05BA56 |
| Proposition 65 List | Lorazepam |
| NIST Chemistry Reference | Lorazepam(846-49-1) |
| EPA Substance Registry System | Lorazepam (846-49-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361 | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 63-39/23/24/25-23/24/25-11-36-20/21/22 | |||||||||
| Safety Statements | 36/37-45-16 | |||||||||
| RIDADR | UN 1230 3/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DF0350000 | |||||||||
| HS Code | 2933910000 | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): 3178, >5000 orally (Owen) | |||||||||
| NFPA 704 |
|
Lorazepam Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Solid
Originator
Tavor,Wyeth,Italy,1972
Uses
An anxiolytic, and anticonvulsant. Controlled substance (depressant)
Definition
ChEBI: Lorazepam is a benzodiazepine.
Manufacturing Process
The starting material was 2-amino-2',5-dichlorobenzophenone which was
reacted with hydroxylamine and then with chloroacetyl chloride. The
intermediate thus obtained is reacted with methylamine and then with acetic
anhydride.
To a slightly warm suspension of 3-acetoxy-7-chloro-5-(o-chlorophenyl)-1,3-
dihydro-2H-1,4-benzodiazepin-2-one thus obtained was added 4N sodium
hydroxide solution with stirring. All the solid dissolved and soon a thick white
solid precipitated out. The solid was filtered, washed well with water and
recrystallized from ethanol. The product was isolated as a solvate with 1 mol
of ethanol. When heated it loses the ethanol of solvation and melts at 166°C
to 168°C.
brand name
Ativan (Baxter Healthcare); Ativan (Biovail); Loraz (Quantum Pharmics).
Therapeutic Function
Tranquilizer
General Description
Lorazepam, 7-chloro-5-(2-chlorophenyl)-3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one(Ativan), is the 2'-chloro derivative of oxazepam. In keepingwith overall SARs, the 2'-chloro substituent increases activity.As with oxazepam, metabolism is relatively rapid anduncomplicated because of the 3-hydroxyl group in the compound.Thus, it also has short half-life (2–6 hours) and similarpharmacological activity.
Biological Activity
Ligand at the GABA A receptor benzodiazepine modulatory site. Anxiolytic, anticonvulsant and sedative/hypnotic agent.
Lorazepam Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
846-49-1(Lorazepam)Related Search:
1of4