ChemicalBook >> CAS DataBase List >>DOTA
DOTA
- CAS No.
- 60239-18-1
- Chemical Name:
- DOTA
- Synonyms
- TETRAXETAN;1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID;2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid;DOTA;98% DOTA;TETRAAZA;NSC 681107;DOTA, ≥97%;DOTA(M-140);TetraxetanuM
- CBNumber:
- CB9398467
- Molecular Formula:
- C16H28N4O8
- Molecular Weight:
- 404.42
- MDL Number:
- MFCD00068657
- MOL File:
- 60239-18-1.mol
- MSDS File:
- SDS
Last updated:2024-04-01 18:08:31
| Melting point | 267 °C |
|---|---|
| Boiling point | 701.6±60.0 °C(Predicted) |
| Density | 1.321 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Water (Slightly, Heated), Methanol (Slightly) |
| pka | 2.16±0.10(Predicted) |
| form | Powder |
| color | white |
| BRN | 1186987 |
| Stability | Hygroscopic |
| FDA UNII | 1HTE449DGZ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10-34 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
DOTA price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 86734 | 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid ≥97.0% (CHN) | 60239-18-1 | 50mg | $138 | 2024-03-01 | Buy |
| Sigma-Aldrich | 86734 | 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid ≥97.0% (CHN) | 60239-18-1 | 250mg | $148 | 2024-03-01 | Buy |
| TCI Chemical | T1875 | 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid >97.0%(T) | 60239-18-1 | 200mg | $157 | 2024-03-01 | Buy |
| TCI Chemical | T1875 | 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid >97.0%(T) | 60239-18-1 | 1g | $552 | 2024-03-01 | Buy |
| Strem Chemicals | 07-1942 | 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid, min. 98% DOTA | 60239-18-1 | 250mg | $120 | 2024-03-01 | Buy |
DOTA Chemical Properties,Uses,Production
Chemical Properties
Colourless crystals
Uses
Bifunctional DOTA aconjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and ther apeutic radiopharmaceuticals.
Uses
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a macrocyclic complexing agent.
- It has been used for radiolabeling of carbon nanotube bioconjugates by chelating 64Cu radioisotope.
- DOTA can be activated with N-hydroxysulfosuccinimidyl for conjugation with monoclonal antibodies in clinical radioimmunotherapy.
- It can form complexes with gadolinium for application as MRI contrast agents.
- Metal complexes of DOTA-peptide conjugates can be used as therapeutic radiopharmaceuticals.
Definition
ChEBI: An azamacrocyle in which four nitrogen atoms at positions 1, 4, 7 and 10 of a twelve-membered ring are each substituted with a carboxymethyl group.
DOTA Preparation Products And Raw materials
Global( 307)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HAINAN POLY PHARMCEUTICAL CO. LTD | +86-0571-89385087 +8613616530509 | ff@hnpoly.com | China | 118 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12457 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from DOTA manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-02 | DOTA
60239-18-1
|
US $0.00 / g | 100g | >95.00% | 100g | Xian confluore Biological Technology Co., Ltd. | |
 |
2023-09-07 | DOTA
60239-18-1
|
US $10.00-1.00 / kg | 1kg | 0.99 | 30 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2023-09-06 | DOTA
60239-18-1
|
US $0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. |
60239-18-1(DOTA)Related Search:
1,4,7,10-Tetrakis(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane
DOTA
Gadoteric acid
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 2-[(4-isothiocyanatophenyl)methyl]-
TETRYL
12-Crown-4
Eu-DOTA,Europium DOTA
TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD
GADOMELITOL
DOTA-[TYR3]-OCTREOTATE,DOTA-[TYR3]-OCTREOTIDE ACID,DOTA-FCYWKTCT (DISULFIDE BRIDGE: 2-7),DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OH (DISULFIDE BRIDGE: 2-7)
1of4
TETRAAZA-12-CROWN-4 TETRAACETIC ACID AMMONIUM SALT (SEE 2923)
Tetraxetan/radical
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrakisacetic acid
2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetryl)tetraacetic acid
2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetryl)tetrakisacetic acid
1,4,7,10-TETRAAZACYCLODODECANE-N,N'',N , N''-TETRAACETIC ACID , (DOTA)
1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID DOTA
DOTA(M-140)
Tetraxetan/DOTA/1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid >=97.0% (CHN)
DOTA Tetraxetan 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid
2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane
-1,4,7,10-tetrayl)tetraacetic acid(DOTA)
1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane
Tetraxetanum (DOTA)
1,4,7,10-Tetraazacyclododecan-N,N',N,N'-tetraacetic acid
TetraxetanuM
1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraaceticacid,min.98%DOTA
1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID, FREE ACID
1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETIC ACID
DOTA
TETRAAZA-12-CROWN-4-1,4,7,10-TETRAACETIC ACID
NSC 681107
TETRAXETAN(DOTA)
Atosiban impurity 9
Gadobutrol Impurity 35
DOTA, ≥97%
98% DOTA
Gadobutrol Impurity 6（DOTA）
DOTA60239-18-1
TETRAAZA
DOTA(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid)
Gadobutrol Impurity 12
2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid
2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid
TETRAXETAN
1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID
Tritracine tetraacetic acid
Gadolinium Butanol Impurity 6
Gadolinium Butanol Impurity 11
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic
(3aR,4aS)-4a-(3-fluorophenyl)-1,3,3a,4a-tetrahydrocyclopropa[1,2-c]furan-1-one
DOTA (TETRAXETAN)
Gadolinium alcohol impurity 6
(1,4,7,10-tetra-carboxymethyl
-1,4,7,10-teraaza-cyclododec
-1-yl)-acetic acid(DOTA)
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid hydrate
2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid
60239-18-1
60239-28-1
C16H28N4O8xH2O
C16H28N4O8
Synthetic Reagents
Crown Ethers
Chelation/Complexation Compounds
Achiral Nitrogen
Cy-N
Azacrown Ethers