Laurocapram
- CAS No.
- 59227-89-3
- Chemical Name:
- Laurocapram
- Synonyms
- AZONE;azon;n-dodecylcaprolactam;n0252;tranzone;NSC11340;usafnd-72;NSC 11340;NSC-11340;USAF NO-72
- CBNumber:
- CB9414646
- Molecular Formula:
- C18H35NO
- Molecular Weight:
- 281.48
- MDL Number:
- MFCD00190580
- MOL File:
- 59227-89-3.mol
- MSDS File:
- SDS
| Melting point | -7° |
|---|---|
| Boiling point | bp50m 160° |
| Density | 0.906-0.926 |
| refractive index | 1.470-1.473 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| pka | -0.43±0.20(Predicted) |
| form | Oil |
| color | Colourless |
| Merck | 14,5385 |
| LogP | 6.570 (est) |
| CAS DataBase Reference | 59227-89-3(CAS DataBase Reference) |
| FDA UNII | 1F3X9DRV9X |
| EPA Substance Registry System | Laurocapram (59227-89-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Safety Statements | 24/25 | |||||||||
| RTECS | CM3995000 | |||||||||
| HS Code | 29339900 | |||||||||
| Toxicity | LD50 rats, mice (g/kg): 8 i.v., i.p. (Stoughton) | |||||||||
| NFPA 704 |
|
Laurocapram price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | L0317 | Laurocapram >96.0%(GC) | 59227-89-3 | 5mL | $44 | 2024-03-01 | Buy |
| TCI Chemical | L0317 | Laurocapram >96.0%(GC) | 59227-89-3 | 25mL | $148 | 2024-03-01 | Buy |
| TRC | L185003 | Laurocapram | 59227-89-3 | 500mg | $75 | 2021-12-16 | Buy |
| Matrix Scientific | 090554 | N-Dodecylcaprolactam 95+% | 59227-89-3 | 1g | $49 | 2021-12-16 | Buy |
| ApexBio Technology | C6524 | Laurocapram | 59227-89-3 | 500mg | $50 | 2021-12-16 | Buy |
Laurocapram Chemical Properties,Uses,Production
Chemical properties
Colorless or slightly yellow transparent liquid, insoluble in water, it can form emulsion with water, soluble in various organic solvents.
Penetration enhancer
Laurocapram, also known as azone, lauric Lun, N-lauryl caprolactam, quinacridone, nitrogen ketone. Its chemical name is 1-n-dodecyl azetidin-2-one, which is a new high security penetration enhancer. It is colorless transparent liquid at room temperature, slightly viscous, odorless. It can form emulsion with water, soluble in various organic solvents, and it has good lubricity, which promote the hydrophilic and lipophilic drug product activity or cosmetics nutrients to penetrate into the skin, greatly reducing the drug remain time in the stratum corneum, significantly enhancing drug efficacy and cosmetic results. Thus, we can reduce the amount of primary medical and reduce costs. Azone transdermal absorption enhancing effect lags behind.
Laurocapram on hydrophilic and lipophilic drugs have significantly transdermal Aided role. It has good aided effect on many kinds of plant extracts in emulsion state or colloidal state, and alkaloids effect is particularly evident. Transdermal penetration is stronger than dimethyl sulfoxide. 8-bromo cyclic nucleotide containing 1% azone permeability effect is equivalent to 12 times the 50% dimethyl sulfoxide. Often in combination with propylene glycol, synergy, the best use of transdermal concentration of 0.1% to 5%, safe and low toxic, non-irritating. The chemical property is stable, and it is kept up to four years at the room temperature.
It can be considered a decyl methyl sulfoxide with pyrrolidone composite for good novel penetration enhancers, skin irritation. It can promote the drug through the skin barrier corticosteroids, indomethacin, fluorouracil, hydroquinone and many other drugs transdermal absorption, improving local and systemic blood concentration, and improving the bioavailability of the drug. Lipophilic, they have transdermal effect for hydrophilic drugs. It can soften the skin and enhance its permeability. They have anti-inflammatory, analgesic and anti-itching effect. Low toxicity, oral LD50> 7g/kg, it is not compatible with strong acids or Vaseline to avoid reduce the effect.
Application
Laurocapram is used as the penetration enhancer in cosmetic preparations and personal-care products. Laurocapram is combined as an excipient (an inert substance) not an active ingredient. Excipients are added to ensure that the shelf-life of the active ingredients can be long enough to be active until internal use. It can be used as a topical smear, massage penetration enhancers; pesticides, as a pro-absorbing agent and sterilization plant growth regulators, pesticides pro penetration; in addition, can be used for coloring and dyeing leather and other areas of accelerator.
References
http://www.chemicalland21.com/lifescience/foco/LAUROCAPRAM.htm
Uses
antifungal lipopeptide
Uses
Laurocapram is a useful intermediate.
Uses
Pharmaceutic aid (excipient).
Laurocapram Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Honest Joy Holdings Limited | 0755-36694831 +8613717124449 | sale@feiyang.com.cn | China | 300 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2967 | 58 |
View Lastest Price from Laurocapram manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-12 | Laurocapram
59227-89-3
|
US $0.00-0.00 / KG | 1KG | 99% | 10000KG/month | Shaanxi Haibo Biotechnology Co., Ltd | |
 |
2024-01-08 | Laurocapram
59227-89-3
|
US $20.00-15.00 / L | 1L | 99.50% | 20 tons | Wuhan Boyuan Import & Export Co., LTD | |
 |
2023-10-07 | Laurocapram
59227-89-3
|
US $40.00-40.00 / kg | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- Laurocapram
59227-89-3
- US $0.00-0.00 / KG
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
-
- Laurocapram
59227-89-3
- US $20.00-15.00 / L
- 99.50%
- Wuhan Boyuan Import & Export Co., LTD
-
- Laurocapram
59227-89-3
- US $40.00-40.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.