ChemicalBook >> CAS DataBase List >>Ethyl S-4-chloro-3-hydroxybutyrate

Ethyl S-4-chloro-3-hydroxybutyrate

Ethyl S-4-chloro-3-hydroxybutyrate structure

CAS No.: 86728-85-0

Chemical Name:: Ethyl S-4-chloro-3-hydroxybutyrate

Synonyms: ETHYL (S)-4-CHLORO-3-HYDROXYBUTANOATE;ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE;ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTYRATE;SECHB;AST-4;PEFC-026;(S)-(?)-4-chL;(S)-Ethyl 4-chloro-3-;oro-3-hydroxybutyrate;4-chloro-3-hydroxyhexanoate

CBNumber:: CB9448087

Molecular Formula:: C6H11ClO3

Molecular Weight:: 166.6

MDL Number:: MFCD00211241

MOL File:: 86728-85-0.mol

MSDS File:: SDS

Last updated:2024-04-03 12:01:51

Request For Quotation

Ethyl S-4-chloro-3-hydroxybutyrate Properties

alpha	-14.5 º (c=neat)
Boiling point	93-95 °C5 mm Hg(lit.)
Density	1.19 g/mL at 25 °C(lit.)
refractive index	n20/D 1.453(lit.)
Flash point	109 °C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	13.23±0.20(Predicted)
form	Liquid
color	Clear colorless to yellow
optical activity	[α]23/D 14°, neat
BRN	4657170
InChI	InChI=1S/C6H11ClO3/c1-2-10-6(9)3-5(8)4-7/h5,8H,2-4H2,1H3/t5-/m0/s1
InChIKey	ZAJNMXDBJKCCAT-YFKPBYRVSA-N
SMILES	C(OCC)(=O)C[C@H](O)CCl
CAS DataBase Reference	86728-85-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H318

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

RIDADR

2810

WGK Germany

HazardClass

6.1

PackingGroup

III

HS Code

29181990

NFPA 704

	0
2		0

Ethyl S-4-chloro-3-hydroxybutyrate price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	460524	Ethyl (S)-(?)-4-chloro-3-hydroxybutyrate 96%	86728-85-0	1g	$15.48	2024-03-01	Buy
Sigma-Aldrich	460524	Ethyl (S)-(?)-4-chloro-3-hydroxybutyrate 96%	86728-85-0	5g	$29.12	2024-03-01	Buy
TCI Chemical	C1717	Ethyl (S)-4-Chloro-3-hydroxybutyrate >95.0%(GC)	86728-85-0	5g	$47	2024-03-01	Buy
TCI Chemical	C1717	Ethyl (S)-4-Chloro-3-hydroxybutyrate >95.0%(GC)	86728-85-0	25g	$85	2024-03-01	Buy
Alfa Aesar	L18554	Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 98%, ee 98%	86728-85-0	1g	$25.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
460524	1g	$15.48	Buy
460524	5g	$29.12	Buy
C1717	5g	$47	Buy
C1717	25g	$85	Buy
L18554	1g	$25.65	Buy

Ethyl S-4-chloro-3-hydroxybutyrate Chemical Properties,Uses,Production

Chemical Properties

Colorless to light yellow liqui

Uses

Ethyl (S)-(?)-4-chloro-3-hydroxybutyrate can be used as a starting material in the synthesis of 4-amino-3-hydroxybutyric acid, a compound of pharmacological importance.

Uses

Atorvastatin Intermediate

Biosynthesis

Bioreductions catalyzed by alcohol dehydrogenases (ADHs) play an essential role in synthesizing chiral alcohols. A novel ADH, SmADH31, obtained from the Stenotrophomonas maltophilia genome, which can tolerate extremely high concentrations (6 M) of both substrate and product. The coexpression of SmADH31 and glucose dehydrogenase from Bacillus subtilis in Escherichia coli meant that as much as 660 g L–1 (4.0 M) ethyl 4-chloroacetoacetate was completely converted into ethyl (S)-4-chloro-3-hydroxybutyrate [(S)-CHBE] in a monophasic aqueous system with a >99.9% ee value and a high space-time yield (2664 g L–1 d–1). In the 100 ml-scale monophasic aqueous system (in triplicate), 66.0 g COBE (single batch charge) can be completely converted to (S)-CHBE (ee >99.9%) in only 6 h with 2 g of the SmADH31/GDH co-expressing cells. After extraction and evaporation, 61.6 g (S)-CHBE was isolated with 92% yield[1].

General Description

Ethyl (S)-4-chloro-3-hydroxybutanoate is a chiral intermediate generally used to prepare atorvastatin, a cholesterol-lowering drug.

References

[1] Zeyu Yang. “Efficient Asymmetric Synthesis of Ethyl (S)-4-Chloro-3-hydroxybutyrate Using Alcohol Dehydrogenase SmADH31 with High Tolerance of Substrate and Product in a Monophasic Aqueous System.” Organic Process Research & Development 24 6 (2020): 1068–1076.

Ethyl S-4-chloro-3-hydroxybutyrate Preparation Products And Raw materials

Raw materials

Preparation Products

Ethyl S-4-chloro-3-hydroxybutyrate Suppliers

Global( 437)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangxi Sunway Chemical Co., Ltd.	+86-0794-5259909 +8615888611133	dave@jxswchem.com	China	22	58
Jiangxi Sunway Chemical Co., Ltd.	+86-0794-5259909 +8615888611133	dave@jxswchem.com	China	22	58
Hangzhou ICH Biofarm Co., Ltd	+undefined8613073685410	sales@ichemie.com	China	985	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7377	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15371	58
Dalian Richfortune Chemicals Co., Ltd	0411-84820922 8613904096939	sales@richfortunechem.com	China	303	57
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60

Supplier	Advantage
Jiangxi Sunway Chemical Co., Ltd.	58
Jiangxi Sunway Chemical Co., Ltd.	58
Hangzhou ICH Biofarm Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Dalian Richfortune Chemicals Co., Ltd	57
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60

View Lastest Price from Ethyl S-4-chloro-3-hydroxybutyrate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-05	Ethyl S-4-chloro-3-hydroxybutyrate 86728-85-0	US $8.00-3.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2023-11-01	Ehyl-4-(-)chloro-3-hydroxybutyrate 86728-85-0	US $0.00-0.00 / KG	1KG	98%	1000	Hangzhou ICH Biofarm Co., Ltd
2023-03-06	Ethyl S-4-chloro-3-hydroxybutyrate 86728-85-0	US $5.00-2.00 / KG	1KG	99%	10000kg	Hebei Guanlang Biotechnology Co,.LTD

Ethyl S-4-chloro-3-hydroxybutyrate
86728-85-0
US $8.00-3.00 / KG
99%
Henan Fengda Chemical Co., Ltd

Ehyl-4-(-)chloro-3-hydroxybutyrate
86728-85-0
US $0.00-0.00 / KG
98%
Hangzhou ICH Biofarm Co., Ltd

Ethyl S-4-chloro-3-hydroxybutyrate
86728-85-0
US $5.00-2.00 / KG
99%
Hebei Guanlang Biotechnology Co,.LTD

Ethyl S-4-chloro-3-hydroxybutyrate Spectrum

Ethyl S-4-chloro-3-hydroxybutyrate(86728-85-0)IR

86728-85-0(Ethyl S-4-chloro-3-hydroxybutyrate)Related Search:

4-Cyanophenol 4-Hydroxybenzoic acid Ethyl acrylate Hydroxy silicone oil Ethyl acetate

2,3,4-Trihydroxybenzoic acid Ethyl isobutyrate Ethanol ETHYL 4-CHLOROBUTYRATE HYDROXYAPATITE TYPE I

Ethyl butyrate Ethylbenzene Glycolic acid Ethyl formate Ethylparaben

Ethyl 3-hydroxybutyrate 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE Acetoxy Empagliflozin

1of4

Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate 96% Butanoic acid,4-chloro-3-hydroxy-, ethyl ester, (3S)- (S) - (-) - chlorine - 4-3 - hydroxy ethyl butyrate Ethyl (3S)-(-)-4-chloro-3-hydroxybutyrate (S)-(-)-ETHYL-4-CHLORO 3-HYDROXYBUTANOATE (S)-ETHYL 4-CHLORO-3-HYDROXYBUTYRATE (S)-(-)-4-CHLORO-3-HYDROXYBUTYRIC ACID ETHYL ESTER (S)-4-CHLORO-3-HYDROXYBUTYRIC ACID ETHYL ESTER (S)-4-CHLORO-3-HYDROXY-N-BUTYRIC ACID ETHYL ESTER Ehyl-4-(-)chloro-3-hydroxybutyrate Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 96% (97% EE/GLC) (2R,4R)-2,4-PENTANEDIOL EE 99+% Ethyl(S)-(-)-4-chloro-3-Hydrox ETHYL(S)-4-CHLORO-3-HYDROXY-BUTYRATE/ATS-4 ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTYRATE , EE 98% methyl 3S-4-chloro-3-hydroxybutanoate Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 98%, ee 98% Ethyl (3S)-4-chloro-3-hydroxybutanoate Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate,97% (S)-(-)-ethyl-4-chloro 3-hydroxybutanoate(ATS-4) Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 96%, ee 98% Ethyl S-4-chloro-3-hydroxybutyate 4-chloro-3-hydroxyhexanoate ethyl()-4-chloro-3-hydroxybutanoate Ethyl(S)-4-chloro-3-hydroxybutylate S-4-Chloro-3-hydroxybutyrate ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTANOATE (-)-ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE BUTANOIC ACID, 4-CHLORO-3-HYDROXY-, ETHYL ESTER, (S) SECHB Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 97% 1GR )-4-chloro-3-hydroxybutyrate (S)-Ethyl 4-chloro-3- AST-4 Oxiracetam (S(-)-4-chloro-3-hydroxybutyric acid ethyl ester) (S)-4-Chloro-3-Hydroxy-Butyric Acid Enthylester PEFC-026 Ethyl (S)-4-Chloro-3-hydroxybutyrate > (S)-(?)-4-chL oro-3-hydroxybutyrate (-)-ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE ETHYL (S)-4-CHLORO-3-HYDROXYBUTANOATE ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTYRATE ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE Butanoic acid, 4-chloro-3-hydroxy-, ethyl ester, (3S)- (9CI, ACI) 4-chloro-3-hydroxy-Butanoic acid ethyl ester (3S)- (9CI ACI) (S)-4-Chloro-3-hydroxybutyric Acid Ethyl Ester(ATS-4) (3S)-4-Chloro-3-hydroxy-butanoic acid ethyl ester Ethyl-(S)-4 chloro-3-hydroxy-Butyrarte Ethyl-S-(-)chloro-3-hydroxybutyrate S (-) -4-chloro-3-hydroxybutyrate ethyl ester 86728-85-0 96728-85-0 C6H11ClO3 Organic Building Blocks Esters Asymmetric Synthesis Chiral Building Blocks