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EOSIN

CAS No.
17372-87-1
Chemical Name:
EOSIN
Synonyms
Acid Red 87;Esoin Y;Eosin Y Na;AMI-5;RED 22;eosina;RED 21 LAKE;EOSIN Y DISODIUM;May-Grünwald Stain;MAY-GRUNWALD STAIN
CBNumber:
CB9461211
Molecular Formula:
C20H6Br4Na2O5
Molecular Weight:
691.85418
MDL Number:
MFCD00005040
MOL File:
17372-87-1.mol
MSDS File:
SDS
Last updated:2024-01-03 17:25:31

EOSIN Properties

Melting point >300°C
Density 1.02 g/mL at 20 °C
vapor pressure 0Pa at 25℃
Flash point 11 °C
storage temp. Store at RT.
solubility H2O: 0.1 g/mL, dark red
Colour Index 45380
form Solid
pka 2.9, 4.5(at 25℃)
color Reddish
PH Range 0(yellow)-3(green fluoresc.)
PH 9.2 (10g/l, H2O, 20℃)
Water Solubility freely soluble
λmax 514nm
Merck 14,3603
BRN 3586809
Stability Stable. Incompatible with strong oxidizing agents.
Biological Applications Treating age-related macular degeneration,burns,cancer,diabetes,obesity,dental bone defects,gastroesophageal reflux disease,prostate cancer,viral diseases; stents; wound-healing materials
Major Application Photovoltaic devices, color filter, nanoscale host material, detection of latent fingerprints, inks, detergents, hair dyes, cosmetics, implantable drug delivery devices, stents, diagnosis of breast lesions, labeling nucleic acids, detecting proteins, stress biomarkers, phosphoprotein, breast cancer metastases, antimicrobial agent, treatment of burns, endodontic, diabetes, obesity, cancer, radiochemotherapy, DNA sequencing, gene expression profiling, wound healing promoters
LogP -1.33
FDA 21 CFR 74.1322; 74.2322; 82.1322
CAS DataBase Reference 17372-87-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII D&C RED NO. 22 (1678RKX8RT)
ACID RED 87 (TDQ283MPCW)
ATC code D08AX02
EPA Substance Registry System Eosin Yellowish (YS) (17372-87-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H317-H319
Precautionary statements  P261-P264-P280-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  F,T,Xn,Xi
Risk Statements  11-23/24/25-39/23/24/25-52/53-41-22-36-10
Safety Statements  7-16-36/37-45-24/25-61-39-26
RIDADR  UN 1230 3/PG 2
WGK Germany  1
RTECS  LM5850000
TSCA  Yes
HS Code  32041200
Toxicity LD50 orally in Rabbit: > 2000 mg/kg
NFPA 704
1
2 0

EOSIN price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 318906 Eosin Y solution 5wt. % in H 17372-87-1 500ml $98.2 2024-03-01 Buy
Sigma-Aldrich 205435 May-Grünwald Stain 17372-87-1 25g $132 2024-03-01 Buy
Sigma-Aldrich 1.15935 Eosin Y (yellowish) (C.I. 45380) for microscopy Certistain? 17372-87-1 100g $400 2023-06-20 Buy
Sigma-Aldrich 200-M Eosin Y Powder 17372-87-1 25g $100 2023-01-07 Buy
Sigma-Aldrich 200-M Eosin Y Powder 17372-87-1 100g $187 2023-01-07 Buy
Product number Packaging Price Buy
318906 500ml $98.2 Buy
205435 25g $132 Buy
1.15935 100g $400 Buy
200-M 25g $100 Buy
200-M 100g $187 Buy

EOSIN Chemical Properties,Uses,Production

Chemical Properties

brownish-red powder

Uses

Eosin is most often used as a counterstain to haematoxylin in H&E (haematoxylin and eosin) staining. H&E staining is one of the most commonly used techniques in histology.

Uses

Anti Septic

Uses

Eosin Yellowish noted to reduce the affinity of Mg2+-ATPase for ATP and increase the enzyme affinity for Mg2+ at concentrations of 10-50 ?M. At higher concentrations near 100 ?M the affinity for Mg2+-ATPase for the ion-activator has been shown to be reduced. This compound has also been reported to be a photosensitizer that works as a molecular photoelectrode via catalyzation of the visible-light-driven electron-transfer reaction. Eosin Y is also used to stain structures such as muscle, cytoplasm, and collagen. This agent also enhances fluorescent quenching abilities by forming a complex with polyvinulpyrrolidone.

Preparation

countries called red. Fluorescent element (C.I. Acid Yellow 73, C.I. 45350) in water or ethanol solution bromine into four bromine derivatives, and then into sodium salt.

Definition

ChEBI: An organic sodium salt that is 2',4',5',7'-tetrabromofluorescein in which the carboxy group and the phenolic hydroxy group have been deprotonated and the resulting charge is neutralised by two sodium ions.

Flammability and Explosibility

Not classified

Biological Activity

ami5/eosin y disodium salt is a non-selective protein methyltransferase inhibitor.post-translational protein methylation at lysine and arginine residues is related to the gene expression regulation. the enzymatic activities of protein methyltransferases serve to do covalent modifications in the control of gene transcription.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of Brand NazO. See also BROMIDES.

in vitro

ami5/eosin y disodium salt has been identified as a competitive inhibitor of sam binding and had been shown to inhibit not only prmts but also lysine methylation by the set7 and disruptor of telomeric silencing 1-like (dot1l) mtases in vitro. both ami5/eosin y disodium salt and its analog ami-1 have been used as lead compounds for the development of novel mtase-specific inhibitors. moreover, it was found that ami5/eosin y disodium salt could inhibit set7 in vitro and decrease h3k4m1 in vascular endothelial cells. [1].

IC 50

0.78 and 1.41 μm for hmt1p and prmt1, respectively

storage

+4°C

Purification Methods

Dissolve it in the minimum volume of H2O (1g/mL), filter and add EtOH until separation of salt is complete. Filter the solid off, wash it with absolute EtOH, then Et2O and dry it first in air, then at 100o. It is used for staining blood cells and for estimating traces of Ag. [Selsted & Becker Anal Biochem 155 270 1986, El-Ghamry & Frei Anal Chem 40 1986 1968.] [Beilstein 19 III/IV 2917.] [See above]

Properties and Applications

yellow peach. Orange powder, soluble in water and ethanol with fluorescent blue light is yellowish red solution. Meet strong sulfuric acid yellow, it will be diluted yellow light red precipitate generated. Dyeing copper ions in the blue colour and lustre; Iron ion colour and lustre in the dark blue. Discharge the gender is good. Mainly used in red ink and red pencils, only comfortable carpet dyeing. After refining can be used as medicine and cosmetics of coloring. Can also be used in leather dyeing. The aluminum salt can be used as organic pigments.

Standard Light Fastness Soaping Persperation Fastness Oxygen bleaching Fastness to seawater
Fading Stain Fading Stain Fading Stain
ISO 2 3 3 2 1 2 2 2
AATCC 1 2 2 3 1 1 3 3

References

[1] okabe j,fernandez az,ziemann m,keating st,balcerczyk a,el-osta a. endothelial transcriptome in response to pharmacological methyltransferase inhibition. chemmedchem.2014 aug;9(8):1755-62.

EOSIN Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 387)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2504 58
Hebei Jingbo New Material Technology Co., Ltd
+8619931165850 admin@hbjingbo.cn China 1000 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Accela ChemBio Inc.
(+1)-858-699-3322 info@accelachem.com United States 19965 58
Shandong chuangyingchemical Co., Ltd.
18853181302 sale@chuangyingchem.com CHINA 5909 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shenyang Simchoice Chemical Co.,Ltd
+86-024-23769576 +86-15040101888 sales@simchoicechem.com China 254 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47464 58

View Lastest Price from EOSIN manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
EOSIN pictures 2024-03-19 EOSIN
17372-87-1
US $82.00 / kg 100kg 99.99% 100Tons Hebei Dangtong Import and export Co LTD
EOSIN pictures 2024-01-04 EOSIN
17372-87-1
US $8.00 / kg 1kg 99% 200000 Hebei Jingbo New Material Technology Co., Ltd
EOSIN pictures 2023-10-09 EOSIN
17372-87-1
US $0.00-0.00 / kg 1kg 99% 50000kg Hebei Yibangte Import and Export Co. , Ltd.
  • EOSIN pictures
  • EOSIN
    17372-87-1
  • US $82.00 / kg
  • 99.99%
  • Hebei Dangtong Import and export Co LTD
  • EOSIN pictures
  • EOSIN
    17372-87-1
  • US $8.00 / kg
  • 99%
  • Hebei Jingbo New Material Technology Co., Ltd
  • EOSIN pictures
  • EOSIN
    17372-87-1
  • US $0.00-0.00 / kg
  • 99%
  • Hebei Yibangte Import and Export Co. , Ltd.
EOSIN Y DISODIUM SALT, CERTIFIED BY THE BIOLOGICAL STAIN COMMISSION EOSIN YELLOWISH SOLUTION 20 G/L, S34 2.5 L EOSIN YELLOWISH SOLUTION, FOR MICROSCOPY EOSIN YELLOWISH, PURUM, WATER-SOLUBLE, FOR MICROSCOPY EOSIN-HEMATOXYLIN SOLUTION ACC. TO EHRLI CH, F. MICROSCOPY EOSIN Y C.I. NO. 45380 , TECHNICAL DYE EOSIN Y SOLUTION INDICATOR EOSIN Y C.I. NO. 45380 FOR MICROSCOPY WATER SOLUBLE 2',4',5',7'-Tetrabromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H), 9'-[9H]xanthan]-3-one disodium salt Disodium 2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate EOSIN DISODIUM SALT 2',4',5',7'-Tetrabromo-3',6'-bis(sodiooxy)spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one Red No. 22 Y Eosin Y water Eosin Y,pure,Indicator grade Eosin Y,pure,high purity, biological stain Eosin Y,pure,certified Eosin yellowish, C.I. 45380, for microscopy Eosin Y water soluti Eosin Y, high purity, biological stain, pure 100GR Eosin Y, high purity, biological stain, pure 25GR Eosin Y, Indicator grade, pure 25GR Acid red 87, Eosin yellowish solution, 2μ,4μ,5μ,7μ-Tetrabromofluorescein disodium salt Eosine Tetrabromofluorescein Sodium Salt EosinY,Water EOSIN Y (YELLOWISH)(C.I. 45380) FOR MICR Eosin sodium salt Tetrabromo(R)fluotrsein sodium salt Tetrabromofluorescin soluble BPW 10X225ML IN 250ML BOTTLE Japan Red No.103 Japan Red No. 230-1 Neelicol Eosine Orient Watger Red 2 Red 103 Red 17255 Silk Discharge Orange 3r Simacid Eosine Y Sodium Eosin Triacid Eosine Vicoacid Eosine bromo4d bromo4dc bromo4dl bromoacid bromob Eosin bromoeosine bromofl bromojps bromots bromoxx bronzebromo c.i.acidred87 certiqualeosine cervenkysela87 d&credno.22 dawnred