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MICROCYSTIN-LR

MICROCYSTIN-LR structure

CAS No.: 101043-37-2

Chemical Name:: MICROCYSTIN-LR

Synonyms: MC-LR;Microcystin-LR solution,Cyanoginosin, Fast-death factor;C05371;MCYST-LR;akerstox;toxin-lr;microcystin-a;MICROCYSTIN-LR;CYANOGINOSIN-LR;Microcystin LR 95%

CBNumber:: CB9463679

Molecular Formula:: C49H74N10O12

Molecular Weight:: 995.17

MDL Number:: MFCD00871766

MOL File:: 101043-37-2.mol

MSDS File:: SDS

Last updated:2023-06-08 09:01:56

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MICROCYSTIN-LR Properties

Density	1.29±0.1 g/cm3(Predicted)
Flash point	11 °C
storage temp.	−20°C
solubility	ethanol: 1 mg/mL
pka	3.03±0.70(Predicted)
form	solid film
color	Off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol or ethanol may be stored at -20°C for up to 2 months.
FDA UNII	EQ8332842Y
IARC	2B (Vol. 94) 2010
EPA Substance Registry System	Microcystin LR (101043-37-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H300+H310-H315-H317-H319-H335

Precautionary statements

P261-P262-P280-P301+P310-P302+P352+P310-P305+P351+P338

Hazard Codes

T+,T,F

Risk Statements

26/27/28-36/37/38-43-39/23/24/25-23/24/25-11

Safety Statements

26-36/37/39-45-36/37-16-7

RIDADR

UN 2811 6.1/PG 1

WGK Germany

RTECS

GT2810000

HS Code

30029090

Toxicity

LD50 orl-rat: >5 mg/kg HETOEA 18,162,1999

NFPA 704

	0
4		0

MICROCYSTIN-LR price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	33893	Microcystin-LR solution 10?μg/mL in methanol, analytical standard	101043-37-2	1mL	$464	2024-03-01	Buy
Cayman Chemical	10007188	Microcystin-LR ≥95%	101043-37-2	100μg	$68	2024-03-01	Buy
Cayman Chemical	10007188	Microcystin-LR ≥95%	101043-37-2	50μg	$29	2021-12-16	Buy
Cayman Chemical	10007188	Microcystin-LR ≥95%	101043-37-2	500μg	$286	2024-03-01	Buy
Cayman Chemical	10007188	Microcystin-LR ≥95%	101043-37-2	1mg	$502	2024-03-01	Buy

Product number	Packaging	Price	Buy
33893	1mL	$464	Buy
10007188	100μg	$68	Buy
10007188	50μg	$29	Buy
10007188	500μg	$286	Buy
10007188	1mg	$502	Buy

MICROCYSTIN-LR Chemical Properties,Uses,Production

Description

Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria. They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC₅₀= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM. The PP1 IC₅₀ is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose.

Definition

ChEBI: Microcystin-LR is a microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins. It has a role as a bacterial metabolite, an EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor, a xenobiotic and an environmental contaminant.

Hazard

A poison by ingestion and inhalation.

Safety Profile

A poison by ingestion, inhalation,intraperitoneal, and intravenous route. Experimentalreproductive effects. When heated to decomposition itemits toxic vapors of NOx.

References

1) Rinehart?et al.?(1988),?Nodularin, microcystin, and the configuration of Adda; J. Am. Chem. Soc.,?110?8557 2) Honkanen?et al. (1990),?Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases;?J. Biol. Chem,?265?19401 3) Runnegar?et al.?(1995),?Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters; Toxicol. Appl. Pharmacol.,?134?264

MICROCYSTIN-LR Preparation Products And Raw materials

Raw materials

Preparation Products

MICROCYSTIN-LR Suppliers

Global( 157)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	86 18062405514 18062405514	ada@ipurechemical.com	CHINA	3465	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58

Supplier	Advantage
Shanghai Zheyan Biotech Co., Ltd.	58
Hubei xin bonus chemical co. LTD	58
Hubei Ipure Biology Co., Ltd	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58

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5-l-arginine-cyanoginosinl 5-l-argininecyanoginosinla MCYST-LR 5-L-ARGININE-MICROCYSTIN LA CYANOGINOSIN-LR Cyanoginosin, Fast-death factor Cyclo[D-Ala-L-Leu-[(3S)-3-methyl-D-βAsp-]-L-Arg-[(2S,3S)-2-methyl-3-[(1E,3E,5S,6S)-3,5-dimethyl-6-methoxy-7-phenyl-1,3-heptadiene-1-yl]-βAla-]-D-γGlu-N-methyl-Dha-] 5-L-Arginine-cyanoginosin C05371 MICROCYSTIN-LR MICROCYSTIN-LR, MICROCYSTIS AERUGINOSA microcystin lr from microcystis aeruginosa microcystin-lr solution TOXIN,BLUE-GREENALGA cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl] akerstox microcystin-a microcystisaeruginosatoxin toxin,bluegreenalga,microcystisaeruginosa toxini(microcystisaeruginosa) toxin-lr toxint17(microcystisaeruginosa) Microcystin-LR solution 10 UG/ML IN METHANOL Microcystin LR 95% CYANOGINOSIN-LR;MC-LR Microcystin LR Solution in Methanol,10μg/mL cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl (5R,8S,11R,12S,15S,18S,19S,22R)-15-(3-guanidinopropyl)-8-isobutyl-18-((1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dien-1-yl)-1,5,12,19-tetramethyl-2-methylene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptaazacyclopentacosane-11,22-dicarboxylic acid MC-LR (5R,8S,11R,12S,15S,18S,19S,22R)-15-(3-guanidinopropyl)-8-isobutyl-18-((1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dien-1-yl)-1,5,12,19-tetramethyl-2-methylene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptaazacyclopentacosane-11,22-dicarboxy Microcystin-LR solution,Cyanoginosin, Fast-death factor Microcystin-LR Standard Solution 101043-37-2 C49H74N10O12 Kinase/Phosphatase Biology Protein Phosphatase 1 (PP1) Serine/Threonine Phosphatase Inhibitors BioChemical Cell Biology Cell Signaling and Neuroscience Natural Products