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Nifuroxazide

CAS No.
965-52-6
Chemical Name:
Nifuroxazide
Synonyms
(nitro-5’furfurylidene-2’)hydroxy-4benzhydrazide;Adral;27-109RC;Nifuzide;RC 30-109;diarlidan;dicoferin;ercefurol;ercefuryl;Bacifurane
CBNumber:
CB9466403
Molecular Formula:
C12H9N3O5
Molecular Weight:
275.22
MDL Number:
MFCD00079482
MOL File:
965-52-6.mol
MSDS File:
SDS
Last updated:2024-03-05 13:26:43

Nifuroxazide Properties

Melting point 281-283°C
Boiling point 418.17°C (rough estimate)
Density 1.3877 (rough estimate)
refractive index 1.5700 (estimate)
storage temp. Inert atmosphere,2-8°C
solubility Practically insoluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
pka 8.36±0.15(Predicted)
color Yellow
BRN 4264976
CAS DataBase Reference 965-52-6(CAS DataBase Reference)
FDA UNII PM5LI0P38J
ATC code A07AX03

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P280
WGK Germany  3
RTECS  DH2528300
Toxicity LD50 intraperitoneal in mouse: 1gm/kg

Nifuroxazide price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 481984 Nifuroxazide 965-52-6 500mg $113 2024-03-01 Buy
Sigma-Aldrich 46494 Nifuroxazide VETRANAL 965-52-6 100mg $50.8 2024-03-01 Buy
Cayman Chemical 18163 Nifuroxazide ≥98% 965-52-6 100mg $32 2024-03-01 Buy
Cayman Chemical 18163 Nifuroxazide ≥98% 965-52-6 1g $243 2024-03-01 Buy
Sigma-Aldrich Y0000836 Nifuroxazide European Pharmacopoeia (EP) Reference Standard 965-52-6 y0000836 $153 2024-03-01 Buy
Product number Packaging Price Buy
481984 500mg $113 Buy
46494 100mg $50.8 Buy
18163 100mg $32 Buy
18163 1g $243 Buy
Y0000836 y0000836 $153 Buy

Nifuroxazide Chemical Properties,Uses,Production

Chemical Properties

Yellow Solid

Originator

Ercefuryl,Carriere,France,1964

Uses

Nifuroxazide is an intestinal antiseptic. Nifuroxazide, is still used as a veterinary drug illegally in some countries. SEE H829102 as a test for antibiotic in broiler chickens.

Definition

Nifuroxazide is a member of benzoic acids. Nifuroxazide is an oral nitrofuran antibiotic used to treat mild diarrhea in humans and animals.

Manufacturing Process

13 g (0.1 mol) of 4-hydroxybenzhydrazide were dissolved in a boiling mixture of 100 ml of water and an equal volume of dimethylformamide. 15.5 g (0.11 mol) of 5-nitrofurfural dissolved in 31 ml of dimethylformamide were added to this hot solution, and the mixture was stirred and brought to the boiling point.
The mixture was then allowed to stand for fifteen hours. The precipitate was separated, washed twice with 100 ml of water, and recrystallized by dissolving it in 250 ml of hot pyridine and pouring this solution into 250 ml of water.
The 5-nitrofurfurylidene hydrazide of 4-hydroxybenzoic acid obtained was washed with water and methanol and was dried at a moderate temperature. It weighed 23 g (83.7% yield), and melted at 298°C. The percentage nitrogen determined by the micro-Dumas method was 15.41% (theory 15.27%).

Therapeutic Function

Antiseptic

Biological Activity

Nifuroxazide is a nitrofuran antibiotic. It is active against strains of the enteropathogenic bacteria C. jejuni, Salmonella, Y. enterocolitica, Shigella, and E. coli. It inhibits quorum sensing and virulence factor production in P. aeruginosa. Nifuroxazide inhibits STAT3 activity in a reporter assay (IC50 = ~3 μM) and decreases viability of U266 and INA-6 myeloma cells, which have constitutive STAT3 phosphorylation, with EC50 values of approximately 4.5 μM for both. It also decreases viability, migration, and invasion of, and induces apoptosis in, MCF-7, 4T1, and MDA-MB-231 breast cancer cells. Nifuroxazide (50 mg/kg per day) reduces tumor growth and prevents pulmonary metastasis in a 4T1 murine mammary carcinoma model. It also reduces diarrhea, weight loss, and colon inflammation in a rat model of acetic acid-induced ulcerative colitis.

698-63-5
5351-23-5
965-52-6
Synthesis of Nifuroxazide from 5-Nitrofurfural and 4-Hydroxybenzhydrazide

Nifuroxazide Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 294)Suppliers
Supplier Tel Email Country ProdList Advantage
Joyochem Co.,Ltd
+86-0531-82687558 +8613290333633 sales@joyochem.com China 42 58
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11001 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
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+8615102730682 bruce@xrdchem.cn CHINA 566 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 alice@crovellbio.com China 8823 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Changzhou Ditong Chemical Co.,Ltd
+86-0519-88299272 info@edengenechem.com China 2169 58

Related articles

View Lastest Price from Nifuroxazide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Nifuroxazide pictures 2024-01-02 Nifuroxazide
965-52-6
US $75.00-750.00 / KG 1KG 0.99 20 tons Zibo Hangyu Biotechnology Development Co., Ltd
Nifuroxazide pictures 2023-09-07 Nifuroxazide
965-52-6
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Nifuroxazide pictures 2023-09-06 Nifuroxazide
965-52-6
US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
  • Nifuroxazide pictures
  • Nifuroxazide
    965-52-6
  • US $75.00-750.00 / KG
  • 0.99
  • Zibo Hangyu Biotechnology Development Co., Ltd
  • Nifuroxazide pictures
  • Nifuroxazide
    965-52-6
  • US $0.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
  • Nifuroxazide pictures
  • Nifuroxazide
    965-52-6
  • US $0.00-0.00 / KG
  • 99%
  • Hebei Guanlang Biotechnology Co., Ltd.

Nifuroxazide Spectrum

4-hydroxy-benzoicaci((5-nitro-2-furanyl)methylene)hydrazide NIFUROXAZIDE p-hydroxybenzoic acid (5-nitrofurfurylidene) hydrazide r.c.27-109 (5-Nitro-2-furfurylidene)(4-hydroxybenzoyl)hydrazine 4-Hydroxybenzoic Acid 2-[(5-Nitro-2-furanyl)methylene]hydrazide Adral Bacifurane Enterofuril Pentofuryl RC 30-109 NIFUROXAZIDE VETRANAL, 250 MG 4-Hydroxybenzoic acid-[[5-nitro-2-furanyl] methylene] hydrazide nitrofuroxazide 1-(p-Hydroxybenzoyl)-2-(5-nitrofurfurylidene)hydrazine 5-Nitro-2-furfurylidene-4-hydroxybenzhydrazide 27-109RC Nifuroxazide COS (E)-4-hydroxy-N'-((5-nitrofuran-2-yl)Methylene)benzohydrazide Benzoic acid,4-hydroxy-, 2-[(5-nitro-2-furanyl)Methylene]hydrazide BENZOIC ACID, 4-HYDROXY-, [(5-NITRO-2-FURANYL)METHYLENE]HYDRAZIDE diarlidan dicoferin ercefurol ercefuryl nifuroxazid p-hydroxy-benzoicaci(5-nitrofurfurylidene)hydrazide 5-NITRO-2-FURALDEHYDE P-HYDROXYBENZOYLHYDRAZONE 4-hydroxy-N'-[(5-nitro-2-furyl)methylene]benzohydrazide 4-hydroxy-N-[(E)-(5-nitrofuran-2-yl)methylideneamino]benzamide Nifuroxazide - CAS 965-52-6 - Calbiochem Nifruoxazide Nitrofurazone Impurity 2 Nifuroxazide CRS 4-Hydroxy-N'-((5-nitrofuran-2-yl)methylene)benzohydrazide Nifuroxazide USP/EP/BP Nifurazide (nitro-5’furfurylidene-2’)hydroxy-4benzhydrazide Nifuzide 965-52-6 C12H9N3O5 Analytical Chromatography Product Catalog Alphabetic Analytical Standards NA - NI API Prevention and control of e. coli ACTIVE PHARMACEUTICAL INGREDIENTS Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals