(+/-)-BAY K 8644
- CAS No.
- 71145-03-4
- Chemical Name:
- (+/-)-BAY K 8644
- Synonyms
- SQ-28873;(RS)-BAY K 8644;BAY K-8644 (+/-);(+/-)-BAY K 8644;(+/-)-BAY K 8644;(±)-Bay K 8644,98%;BAYK 8644 (racemate);BAYK 8644; BAYK8644; BAYK-8644;(+/-)-BAY K8644 CALCIUM SLOW CHANNEL;(+/-)-Bay K8644 calcium channel agonist
- CBNumber:
- CB9471784
- Molecular Formula:
- C16H15F3N2O4
- Molecular Weight:
- 356.3
- MDL Number:
- MFCD00036697
- MOL File:
- 71145-03-4.mol
- MSDS File:
- SDS
| Melting point | 166 °C |
|---|---|
| Boiling point | 429.2±45.0 °C(Predicted) |
| Density | 1.3548 (estimate) |
| RTECS | US5655000 |
| storage temp. | 2-8°C |
| solubility | DMSO: 184 mg/mL |
| pka | -3.43±0.70(Predicted) |
| form | Yellow solid. |
| color | Yellow |
| Water Solubility | Soluble in DMSO at 20mg/ml. Also soluble in methanol or ethanol at 60mg/ml. Insoluble in water |
| Stability | Stable. Incompatible with strong oxidizing agents. |
(+/-)-BAY K 8644 price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B112 | (±)-Bay K8644 calcium channel agonist | 71145-03-4 | 5mg | $349 | 2024-03-01 | Buy |
| Sigma-Aldrich | B112 | (±)-Bay K8644 calcium channel agonist | 71145-03-4 | 25mg | $1390 | 2024-03-01 | Buy |
| Alfa Aesar | J61480 | (±)-Bay K 8644 | 71145-03-4 | 5mg | $178.65 | 2024-03-01 | Buy |
| Cayman Chemical | 21479 | (±)-Bay K 8644 ≥98% | 71145-03-4 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21479 | (±)-Bay K 8644 ≥98% | 71145-03-4 | 5mg | $72 | 2024-03-01 | Buy |
(+/-)-BAY K 8644 Chemical Properties,Uses,Production
Description
BAY K8644 (71145-03-4) is an L-type Ca2+-channel activator with positive inotropic and vasoconstrictive effects.
Chemical Properties
yellow powder
Uses
An active L-type, voltage-gated calcium channel agonist
Definition
ChEBI: Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate is a pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6. It is a dihydropyridine, a methyl ester, a C-nitro compound and a member of (trifluoromethyl)benzenes.
Biological Activity
L-type Ca 2+ -channel activator (EC 50 = 17.3 nM). Has positive inotropic, vasoconstrictive and behavioral effects in vivo . Separate enantiomers also available ((4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromet hyl)phenyl]-3-pyridinecarboxylic acid methyl ester and (4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromet hyl)phenyl]-3-pyridinecarboxylic acid methyl ester).
Biochem/physiol Actions
(±)-Bay K8644 is a 1,4-dihydropyridine (DHP) derivative and an agonist for L-type Ca2+ channels. However, it′s enantiomers (-)-BAY k8644 and (+)-BAY k8644 have opposing functionality with respect to Ca2+ channels as high-potency agonist and low-potency antagonist, respectively. (±)-Bay K8644 increases influx of Ca2+ specifically at voltage-gated calcium channels. It constricts blood vessels and heart contraction.
in vitro
it was demonstrated that bay k 8644 prolonged the mean ca2+ channel opening time in heart myocytes and neurones of spinal ganglia. an experiment using rat heart ventricles demonstrated that bay k 8644, at the final concentration of approximately 1 pm, had strong positive inotropic effect when added to the perfusion fluid. moreover, the addition of bay k 8644 to the chronic ethanol treatment significantly reduced the electrophysiological signs of withdrawal in the isolated hippocampal slices. [2, 3]
in vivo
study in mice demonstrated that bay k 8644 significantly ameliorated the ethanol withdrawal syndrome. when experimental animals were administered with an acute injection of bay k 8644, the convulsive behavior of mice could be monitored to increase for 2 hours. in addition, bay k 8644 was also reported to ameliorate hypotension in endotoxin-shocked rats. it could lead to a 37% decrease in heart rate of endotoxin-treated rats and 39% decrease in control rats in a dose-dependent manner. [3,4]
storage
+4°C
References
1) Schramm?et al. (1983)?Novel Dihydropyridines with positive inotropic action through activation of Ca2+ channels; Nature,?303?535 2) Yamamoto?et al. (1984)?Bay K8644 Differentiates between potential and receptor operated Ca2+ channels; Eur. J. Pharmacol.?102?555 3) Thomas?et al. (1985)?A dihydropyridine (Bay K 8644) that enhances calcium currents in guinea pig and calf myocardial cells. A new type of positive inotropic agent; Circ. Res.,?56?87 4) Shi?et al. (2009)?Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small molecule compounds; Cell Stem Cell,?3?568
(+/-)-BAY K 8644 Preparation Products And Raw materials
Raw materials
Preparation Products
(+/-)-BAY K 8644 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
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