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SB216763

CAS No.
280744-09-4
Chemical Name:
SB216763
Synonyms
CS-332;SB 216763;SB216763 USP/EP/BP;SB-216763(SB 216763);3-(2,4-Dichlorophenyl)-4-...;GSK-3 Inhibitor IV, SB-216763;3-(1-methyl-indol-3-yl)-4-(2,4-dichloro-phenyl-)-maleimide;GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem;3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione;3-(2,4-DICHLOROPHENYL)-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
CBNumber:
CB9493416
Molecular Formula:
C19H12Cl2N2O2
Molecular Weight:
371.22
MDL Number:
MFCD09753369
MOL File:
280744-09-4.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

SB216763 Properties

Melting point 287-288.6 °C(lit.)
Boiling point 598.1±50.0 °C(Predicted)
Density 1.47±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: 20 mg/mL, soluble
form Orange solid
pka 7.27±0.60(Predicted)
color orange
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  29339900
NFPA 704
0
2 0

SB216763 price More Price(61)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S3442 SB 216763 >98% (HPLC) 280744-09-4 5mg $178 2024-03-01 Buy
Sigma-Aldrich S3442 SB 216763 >98% (HPLC) 280744-09-4 25mg $708 2024-03-01 Buy
TCI Chemical B5716 SB 216763 >98.0%(HPLC) 280744-09-4 10mg $118 2024-03-01 Buy
TCI Chemical B5716 SB 216763 >98.0%(HPLC) 280744-09-4 50mg $352 2024-03-01 Buy
Cayman Chemical 10010246 SB 216763 ≥98% 280744-09-4 5mg $73 2024-03-01 Buy
Product number Packaging Price Buy
S3442 5mg $178 Buy
S3442 25mg $708 Buy
B5716 10mg $118 Buy
B5716 50mg $352 Buy
10010246 5mg $73 Buy

SB216763 Chemical Properties,Uses,Production

Description

SB-216763 (280744-09-4) is a potent and selective inhibitor of glycogen synthase kinase-1 (GSK-3) IC50=34.3 nM.1 Acts at the ATP-binding domain. Displays protective effects in lung fibrosis mouse model.2 Displays neuroprotective effects on cultured neurons.3 SB-216763 maintains mouse embryonic stem cells in a pluripotent state.4?Cell permeable.

Uses

SB 216763 is a potent and selective cell permeale ATP-competitive inhibitor of GSK3a. It stimulates glycogen synthesis in Chang human liver cells.

Uses

SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line and colorectal cancer cells.

Definition

ChEBI: 3-(2,4-dichlorophenyl)-4-(1-methyl-3-indolyl)pyrrole-2,5-dione is a member of indoles and a member of maleimides.

Biological Activity

Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (K i = 9 nM for GSK-3 α ); competes with ATP. Has minimal activity against 24 other protein kinases (IC 50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

Biochem/physiol Actions

SB-216763 is a small molecule that competes with ATP and potently inhibits the activity α and β isozymes of GSK-3. It acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. It also delays preconditioning, reduces infarct size and prevents cardiac ischemia.

storage

Room temperature

References

1) Coghlan et al. (2000), Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription; Chem. Biol., 7 793 2) Gurrieri et al. (2010), 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis; J. Pharmacol. Exp. Ther., 332 785 3) Cross et al. (2001), Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurons from death; J. Neurochem., 77 94 4) Kirby et al. (2012), Glycogen synthase kinase 3 (GSK3) inhibitor , SB-216763, promotes pluripotency in mouse embryonic stem cells; PLoS One, 7 e39329

SB216763 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 171)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 967 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Hong Kong Tiansheng New Material Trading Co., Ltd
+8617320695765 zxx@hktiansheng.com China 981 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58

View Lastest Price from SB216763 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SB216763 pictures 2022-02-25 SB216763
280744-09-4
US $19.00 / KG 1KG 98% 100KG Hong Kong Tiansheng New Material Trading Co., Ltd
SB216763 pictures 2022-02-25 SB216763
280744-09-4
US $19.00 / KG 1KG 99% 10kg Hong Kong Tiansheng New Material Trading Co., Ltd
SB216763 pictures 2019-07-06 SB216763
280744-09-4
US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co
  • SB216763 pictures
  • SB216763
    280744-09-4
  • US $19.00 / KG
  • 98%
  • Hong Kong Tiansheng New Material Trading Co., Ltd
  • SB216763 pictures
  • SB216763
    280744-09-4
  • US $19.00 / KG
  • 99%
  • Hong Kong Tiansheng New Material Trading Co., Ltd
  • SB216763 pictures
  • SB216763
    280744-09-4
  • US $2.00 / kg
  • 99%
  • Career Henan Chemical Co

SB216763 Spectrum

SB 216763 3-(2,4-DICHLOROPHENYL)-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE 3-(2,4-Dichlorophenyl)-4-... 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione SB-216763(SB 216763) GSK-3 Inhibitor IV, SB-216763 CS-332 GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem 3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione 1H-Pyrrole-2,5-dione, 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)- SB216763 USP/EP/BP 3-(1-methyl-indol-3-yl)-4-(2,4-dichloro-phenyl-)-maleimide 280744-09-4 C19H12Cl2N2O2 C19H12N2O2Cl2 C19Cl2H12N2O2 Cell Signaling and Neuroscience Cell Biology BioChemical Glycogen Synthase Kinase 3 (GSK3) Kinase/Phosphatase Biology Serine/Threonine Kinase Inhibitors Inhibitors Akt mTOR PI3K Protein Kinase Signalling