ChemicalBook >> CAS DataBase List >>1-Methyl-4-piperidone

1-Methyl-4-piperidone

1-Methyl-4-piperidone structure

CAS No.: 1445-73-4

Chemical Name:: 1-Methyl-4-piperidone

Synonyms: N-METHYL-4-PIPERIDONE;1-METHYL-4-PIPERIDINONE;1-Methyl-piperidin-4-one;N-METHYL-GAMMA-PIPERIDONE;1-METHYLTETRAHYDROPYRIDIN-4(1H)-ONE;NSC 66491;AKOS BBS-00004237;N-METHYLPIPERIDONE;-Methyl-4-piperidone;N-Methyl-4-Pperidone

CBNumber:: CB9684827

Molecular Formula:: C6H11NO

Molecular Weight:: 113.16

MDL Number:: MFCD00006191

MOL File:: 1445-73-4.mol

MSDS File:: SDS

Last updated:2024-03-18 17:23:41

Request For Quotation

1-Methyl-4-piperidone Properties

Melting point	192-193 °C(Solv: ethyl acetate (141-78-6))
Boiling point	55-60 °C11 mm Hg(lit.)
Density	0.92 g/mL at 25 °C (lit.)
refractive index	n20/D 1.460
Flash point	140 °F
storage temp.	Store below +30°C.
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka	8.02±0.20(Predicted)
form	Liquid
Specific Gravity	0.92
color	Clear yellow to orange
PH	12 (100g/l, H2O, 20℃)
Water Solubility	MISCIBLE
Sensitive	Air Sensitive
BRN	106924
CAS DataBase Reference	1445-73-4(CAS DataBase Reference)
NIST Chemistry Reference	4-Piperidinone, 1-methyl-(1445-73-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02

Signal word

Warning

Hazard statements

H226

Precautionary statements

P210-P233-P240-P241-P242-P243

Hazard Codes

C,Xi

Risk Statements

34-10-36/37/38

Safety Statements

23-24/25-37/39-26

RIDADR

UN 1224 3/PG 3

WGK Germany

Hazard Note

Irritant

HazardClass

PackingGroup

III

HS Code

29333999

NFPA 704

	2
1		0

1-Methyl-4-piperidone price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	130036	N-Methyl-4-piperidone 97%	1445-73-4	5ml	$37.8	2024-03-01	Buy
Sigma-Aldrich	130036	N-Methyl-4-piperidone 97%	1445-73-4	100ml	$129	2024-03-01	Buy
Sigma-Aldrich	8.20828	1-Methyl-4-piperidinone for synthesis	1445-73-4	100mL	$150	2024-03-01	Buy
TCI Chemical	M0530	1-Methyl-4-piperidone >98.0%(GC)(T)	1445-73-4	25g	$33	2024-03-01	Buy
TCI Chemical	M0530	1-Methyl-4-piperidone >98.0%(GC)(T)	1445-73-4	100g	$86	2024-03-01	Buy

Product number	Packaging	Price	Buy
130036	5ml	$37.8	Buy
130036	100ml	$129	Buy
8.20828	100mL	$150	Buy
M0530	25g	$33	Buy
M0530	100g	$86	Buy

1-Methyl-4-piperidone Chemical Properties,Uses,Production

Chemical Properties

clear yellow to orange liquid

Uses

1-Methyl-4-piperidone, are widely used in artificial fibre industry. They are polymerizable and used as nylon precursors. They have excellent applications as solvents and as intermediates for organic synthesis. They are used in the aqueous carrier medium and amide penetrants in inks and water soluble paints.

Application

N-Methyl-4-piperidone can be used as a reactant to prepare:
Spiropiperidine rings by reacting with malononitrile and electrophiles or Michael acceptors.
(3E,5E)-1-Methyl-3,5-bis(phenylmethylene)-4-piperidinone by reacting with benzaldehyde via Michael addition, followed by intramolecular O-cyclization/elimination sequential reactions.
N,N′-Dimethylbispidinone by utilizing a double Mannich condensation method.

Preparation

[JACS (1948) vol 70 p 1820] for the synthesis of 1-methyl-4-piperidone:
To a one-liter flask containing 350 ml of 20 % hydrochloric acid was added 86 g. of 1-methyl-3-carbethoxy-4-piperidone hyrdrochloride. After refluxing for one hour, the ferric chloride reagent gave no coloration. The solution was evaporated to dryness on a steam-bath at 10 mm. pressure. The solid product, heated at 100 °C for 4 hours at 0.1 mm and further dried over solid KOH for 24 hours, weighed 57.7 g, m.p. 80 - 120 °C.
Although this melting range goes above that of the pure comound 0.45 of crude material dissolved in 90 ml. of hot acetone gave 0.40 g of pure compoundd melting at 93 - 95 °C. Other samples of crude piperidone hydrochloride showed even higher melting points than the one mentioned above, yet this apperently impure material always gave good yields of sharp melting product when recrystallized.

Purification Methods

It is best purified by fractional distillation The hydrochloride of the hydrate (4-diol) has m 94.7-95.5o, but the anhydrous hydrochloride which crystallises from CHCl3/Et2O has m 165-168o (164-167o) and can also be obtained by sublimation at 120o/2mm. The oxime has m 130-132o (from Me2CO). The methiodide crystallises from MeOH, the crystals with 1MeOH have m 189-190o, and the solvent-free iodide has m 202-204o(dec). [Lyle et al. J Org Chem 24 342 1959, Bowden & Greeen J Chem Soc 1164 1952, Tomita Yakugaku Zasshi (J Pharm Soc Japan) 71 1053 1951, Beilstein 21 IIII/IV 3183, 21/6 V 419.]

1-Methyl-4-piperidone synthesis

Synthesis of 1-Methyl-4-piperidone from Methylamine and Benzene

1-Methyl-4-piperidone Preparation Products And Raw materials

Raw materials

Preparation Products

N-Methyl-3-carbomethoxy-4-piperidone hydrochloride 4-Chloro-N-methylpiperidine 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE-3-CARBONITRILE N-Methyl-4-piperidinol 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride

5-BENZYL-2-METHYL-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE ETHYL 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE-3-CARBOXYLATE 5,6,7,8-TETRAHYDRO-6-METHYL-1,6-NAPHTHYRIDIN-3-AMINE 4-METHYLENEPIPERIDINE PYRIDINE, 4,4'-[1,1'-BIPHENYL]-4,4'-DIYLBIS-

5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-AMINE 4-CHLORO-3-IODOPYRIDINE N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide 2,2,2-Trifluoroacetate 1-(1-Methyl-4-piperidinyl)piperazine

1of3

1-Methyl-4-piperidone Suppliers

Global( 566)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12382	58
Anhui Yiao New Material Technology Co., Ltd	+86-199-55145978 +8619955145978	sales8@anhuiyiao.com	China	253	58
Henan Tengmao Chemical Technology Co. LTD	+8615238638457	salesvip2@hntmhg.com	China	415	58
Anhui Zhongda Biotechnology Co., Ltd	+8619956560829	justine@zhongda-biotech.com	China	300	58
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	sales03@chemcn.cn	China	951	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	885	50
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60

Supplier	Advantage
sgtlifesciences pvt ltd	58
Anhui Yiao New Material Technology Co., Ltd	58
Henan Tengmao Chemical Technology Co. LTD	58
Anhui Zhongda Biotechnology Co., Ltd	58
hebei hongtan Biotechnology Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Shanghai Time Chemicals CO., Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60

View Lastest Price from 1-Methyl-4-piperidone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-12	1-Methyl-4-piperidone 1445-73-4	US $10.00 / kg	1kg	99%	1000kg	hebei hongtan Biotechnology Co., Ltd
2024-02-26	1-Methyl-4-piperidone 1445-73-4	US $0.00-0.00 / kg	1kg	99%	Kgs	BTC Nantong Pharmaceuticals Technology Co.,Ltd
2024-01-04	1-Methyl-4-piperidone 1445-73-4	US $110.00-90.00 / kilogram	1kilogram	99%	10 tons/per week	Henan Tengmao Chemical Technology Co. LTD

1-Methyl-4-piperidone
1445-73-4
US $10.00 / kg
99%
hebei hongtan Biotechnology Co., Ltd

1-Methyl-4-piperidone
1445-73-4
US $0.00-0.00 / kg
99%
BTC Nantong Pharmaceuticals Technology Co.,Ltd

1-Methyl-4-piperidone
1445-73-4
US $110.00-90.00 / kilogram
99%
Henan Tengmao Chemical Technology Co. LTD

1-Methyl-4-piperidone Spectrum

1-Methyl-4-piperidone(1445-73-4)MS 1-Methyl-4-piperidone(1445-73-4)¹HNMR 1-Methyl-4-piperidone(1445-73-4)¹³CNMR 1-Methyl-4-piperidone(1445-73-4)IR1 1-Methyl-4-piperidone(1445-73-4)Raman

1445-73-4(1-Methyl-4-piperidone)Related Search:

METSULFURON METHYL 2,2,6,6-Tetramethyl-4-piperidinol Methyl salicylate 4-Methyl-2-pentanone 2,2,6,6-Tetramethylpiperidinooxy

Norgestrel Thiophanate-methyl Tribenuron methyl Pirimiphos-methyl Methyl acetate

Kresoxim-methyl N-Methyl-2-pyrrolidone Mesotrione 4-Piperidinone 1-Methyl-1H-pyrazol-3-amine

2-(1-Methylpiperidin-4-yl)ethanamine 4-BROMO-N-METHYL PIPERIDINE Edoxaban Impurity 12 (1R,2R,4S)

1of4

1-METHYL-4-PIPERIDONE N-METHYLPIPERIDONE AKOS BBS-00004237 4-PIPERIDINONE, 1-METHYL- 1-Methyl-4-piperidone,98% N-Methyl-4-piperidone ,98% N-Methyl-4-Pperidone -Methyl-4-piperidone 1-Methyl-4-piperidone, 98% 100GR 1-Methyl-4-piperidone, 98% 500GR NSC 66491 1-Met 1-Methyl -4-piperidone N-METHYLPIPERIDIN-4-ONE 1-Methylpiperid-4-one 1-METHYL-4-PIPERIDONE 98% 1-Methylpiperidin-4-one 98+% 1-Methyl-4-piperidinone for synthesis 1 - Methyl - 4 - piperidine ketone 4-Piperidone, 1-methyl- 4-Piperidone,1-methyl- N-Methyl-4-piperidinone N-Methyl-4-piperidon 1-Methyl-4-oxopiperidine 1-Methyl-4-piperidione 1-Methylpiperidine-4-one 1-Methylpiperidone-(4) N-Methyl-4-piperidone cas 1445-73-4 Pimavanserin Impurity 11 1-Methyl-4-piperidone> Edoxaban Impurity 69 N-Methyl-4-piperidone(NMP) Domperidone Impurity 25 N-Methyl-4-Piperidine -Methyl-4-piperidone 1-METHYL-4-PIPERIDINONE 1-METHYLTETRAHYDROPYRIDIN-4(1H)-ONE N-METHYL-GAMMA-PIPERIDONE N-METHYL-4-PIPERIDONE 1-Methyl-piperidin-4-one 1445-73-4 445-73-4 971445-73-4 Building Blocks Heterocyclic Building Blocks Piperidones KETONE Miscellaneous Piperidines, Piperidones, Piperazines PHARMACEUTICAL INTERMEDIATES Amines and Anilines Carbonyl Compounds Piperidine Heterocycles Miscellaneous Reagents Building Blocks Heterocyclic Building Blocks Piperidones Thiadiazoles