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3-Chloroaniline

CAS No.
108-42-9
Chemical Name:
3-Chloroaniline
Synonyms
M-CHLOROANILINE;3-CHLOROBENZENAMINE;ORANGE GC BASE;1,3-aminochlorobenzene;oroaniL;CI 37005;3-Chloranilin;3-Cloroaniline;m-Chloraniline;3-Chloraniline
CBNumber:
CB9697982
Molecular Formula:
C6H6ClN
Molecular Weight:
127.57
MDL Number:
MFCD00007765
MOL File:
108-42-9.mol
Last updated:2024-03-19 15:37:50

3-Chloroaniline Properties

Melting point −11-−9 °C(lit.)
Boiling point 95-96 °C11 mm Hg(lit.)
Density 1.206 g/mL at 25 °C(lit.)
vapor pressure 1 mm Hg ( 63.5 °C)
refractive index n20/D 1.594(lit.)
Flash point 255 °F
storage temp. Store below +30°C.
solubility 6.2g/l
pka 3.46(at 25℃)
form Liquid
color Clear pale yellow to brown
PH 7.3 (H2O)(saturated aqueous solution)
Odor Characteristic odour
Water Solubility 6.8 g/L (20 ºC)
Decomposition 190°C
Merck 14,2118
BRN 605969
Dielectric constant 13.4(19℃)
Stability Material darkens in storage with no loss in purity, Material Darkens In Storage
LogP 0.77-2.03 at 25-30℃
CAS DataBase Reference 108-42-9(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 6GKR52SKIY
NIST Chemistry Reference m-Chloroaniline(108-42-9)
EPA Substance Registry System m-Chloroaniline (108-42-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H301+H311-H317-H319-H330-H373-H410
Precautionary statements  P273-P280-P302+P352+P312-P304+P340+P310-P305+P351+P338-P314
Hazard Codes  T,N
Risk Statements  23/24/25-33-50/53
Safety Statements  28-36/37-45-60-61-28A
RIDADR  UN 2019 6.1/PG 2
WGK Germany  2
RTECS  BX0350000
8-10-23
Autoignition Temperature 705 °C
Hazard Note  Toxic
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29214210
Toxicity LD50 orally in Rabbit: 256 mg/kg LD50 dermal Rat 250 mg/kg
NFPA 704
0
2 0

3-Chloroaniline price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C22407 3-Chloroaniline 99% 108-42-9 5g $40.2 2024-03-01 Buy
Sigma-Aldrich C22407 3-Chloroaniline 99% 108-42-9 100g $55 2024-03-01 Buy
TCI Chemical C0110 3-Chloroaniline >99.0%(GC) 108-42-9 25mL $18 2024-03-01 Buy
TCI Chemical C0110 3-Chloroaniline >99.0%(GC) 108-42-9 500mL $93 2024-03-01 Buy
Alfa Aesar A12019 3-Chloroaniline, 99% 108-42-9 100g $36.1 2024-03-01 Buy
Product number Packaging Price Buy
C22407 5g $40.2 Buy
C22407 100g $55 Buy
C0110 25mL $18 Buy
C0110 500mL $93 Buy
A12019 100g $36.1 Buy

3-Chloroaniline Chemical Properties,Uses,Production

Description

m-Chloroaniline is used as an intermediate for pesticides, pharmaceuticals, and dyes. It is produced by lowpressure hydrogenation of 3-chloronitrobenzene in the liquid phase with noble metal and/or noble metal sulfide catalysts. The addition of metal oxides to the reaction helps avoid dehalogenation. The yield is approximately 98 %.

Chemical Properties

3-Chloroaniline is a clear pale yellow to brown liquid, which becomes darker during storage, insoluble in water, but soluble in ethanol, ether and acid solution.

Application

3-Chloroaniline is the intermediate of the herbicide chloraniline, and the intermediate of the pharmaceutical diuretic antihypertensive drug hydrochlorothiazide, and can be used to produce azo dyes.
3-Chloroaniline was the only aniline compound to increase plasmaALT/GPT activity at 48 h. It is employed in the bioaugmentation of activated sludge.

Uses

3-Chlorobenzenamine is used in the synthesis of pyrimidoazepine analogs as serotonin 5-HT2A and 5-HT2C receptor ligands for the treatment of obesity. Also used in the synthesis of novel COX-2 inhibito rs.

Preparation

3-Chloroaniline is obtained by reducing 3-Nitrochlorobenzene with iron powder in the presence of ferrous sulfate.

Synthesis Reference(s)

Tetrahedron Letters, 36, p. 7313, 1995 DOI: 10.1016/0040-4039(95)01474-V

General Description

Colorless to light amber liquid with a sweet odor.

Air & Water Reactions

Sensitive to prolonged exposure to air and light and tends to darken during storage. Insoluble in water.

Reactivity Profile

3-Chloroaniline is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents.

Fire Hazard

3-Chloroaniline is combustible.

Flammability and Explosibility

Non flammable

Safety Profile

Poison by ingestion, skin contact, subcutaneous, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of Cland NOx. See also ANILINE DYES.

121-73-3
108-42-9
Synthesis of 3-Chloroaniline from 1-Chloro-3-nitrobenzene
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View Lastest Price from 3-Chloroaniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Chloroaniline pictures 2023-10-08 3-Chloroaniline
108-42-9
US $30.00 / KG 1KG 99% 20T Firsky International Trade (Wuhan) Co., Ltd
3-Chloroaniline pictures 2023-07-19 3-Chloroaniline
108-42-9
US $10.00-100.00 / KG 1KG 99% 20 Tons Wuhan wingroup Pharmaceutical Co., Ltd
3-Chloroaniline pictures 2023-06-20 3-Chloroaniline
108-42-9
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
  • 3-Chloroaniline pictures
  • 3-Chloroaniline
    108-42-9
  • US $30.00 / KG
  • 99%
  • Firsky International Trade (Wuhan) Co., Ltd
  • 3-Chloroaniline pictures
  • 3-Chloroaniline
    108-42-9
  • US $10.00-100.00 / KG
  • 99%
  • Wuhan wingroup Pharmaceutical Co., Ltd
3-Cloroaniline Aniline, 3-chloro- Aniline, m-chloro- Azoic diazo component 2, base Benzenamine, 3-chloro- Benzenamine,3-chloro- Benzeneamine, 3-chloro- chloro-3aniline m-Chloraniline m-Chloroaminobenzene m-chloro-anilin m-Chlorophenylamine meta-aminochlorobenzene AKOS BBS-00003568 3-CHLOROANILINE 3-CHLOROPHENYLAMINE 3-Chloroaniline, 99% 100ML 3-Chloroaniline 99% Inter Chloroaniline Between chloroaniline 3-chlorobenzeneamine 3-Chloroaniline base m-Aminochlorobenzene 3-Chlorobenzenamine 3-Chlooranilinen 3-chloro-benzenamin LABOTEST-BB LT00436952 m-Aminochlorobenzene META-CHLOROANILINE CHLOROANILINE(M-) CI 37005 FAST ORANGE GC BASE FAST ORANGE BASE GC 3-CHLOROANILINE 99% (GC) 3-CHLOROANILINE PESTANAL 3-Chloroaniline,>99% 3-ChloroanilineForSynthesis META CHLOROANILINE (DRUMS) 3-Chloranilin 1-AMINO-3-CHLOROBENZENE 3-Chlorobenzamine C.I.Azoic Diazo Component 2【base】 Methylene Blue solution,Ehrlich’s reagent III, Loeffler’s Methylene Blue 3-Chloroaniline (C.I. 37005) 3-CHLOROANILINE, 99% (SEE 2193) 3-CHLOROANILINE, 99% (SEE 2558) 3-Chloraniline m-CHLOROANILINE pract 3-Aminochlorobenzene 3-Chloroaniline 5g [108-42-9] oroaniL 3-ChoroanilineSolution,100mg/L,5x1ml 3-ChoroanilineSolution,100mg/L,1ml 3-Chloroaniline > 3-ChoroanilineSolution,1000mg/L,1ml 3-ChloroanilineN,N-Diethyl-4-nitrosoaniline HCl 3-Chloroaniline Solution in Methanol, 1000μg/mL 3-?Chloroaniline (3-Chlorobenzenamine) MCA meta chloro aniline