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Chlorhexidine digluconate

Chlorhexidine digluconate
Chlorhexidine digluconate
CAS No.
18472-51-0
Chemical Name:
Chlorhexidine digluconate
Synonyms
abacil;D00858;d-)(2:1;hibidil;placout;septeal;unisept;corsodyl;disteryl;orahexal
CBNumber:
CB9702888
Molecular Formula:
C34H54Cl2N10O14
Formula Weight:
897.76
MOL File:
18472-51-0.mol

Chlorhexidine digluconate Properties

Density 
1.06 g/mL at 25 °C(lit.)
storage temp. 
2-8°C
solubility 
water: soluble50% (w/v)
form 
Liquid
color 
Colorless
Sensitive 
Light Sensitive
λmax
257nm(H2O)(lit.)
Merck 
14,2091
InChIKey
YZIYKJHYYHPJIB-UUPCJSQJSA-N
CAS DataBase Reference
18472-51-0(CAS DataBase Reference)
EPA Substance Registry System
D-Gluconic acid, compd. with N,N''-bis(4-chlorophenyl)- 3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)(18472-51-0)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  N
Risk Statements  50/53
Safety Statements  61
RIDADR  UN 3082 9 / PGIII
WGK Germany  -
RTECS  DU1950000
TSCA  Yes
HazardClass  9
PackingGroup  III
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Chlorhexidine digluconate price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C9394 Chlorhexidine digluconate solution 20% in H 18472-51-0 25ml $38.7 2017-11-08 Buy
Sigma-Aldrich C9394 Chlorhexidine digluconate solution 20% in H 18472-51-0 100ml $96.8 2017-11-08 Buy
TCI Chemical C3105 Chlorhexidine Digluconate (20% in Water) 18472-51-0 25mL $28 2017-11-08 Buy
Alfa Aesar 41385 Chlorhexidine digluconate, 20% w/v aq. soln., non-sterile 18472-51-0 25ml $25.2 2017-11-08 Buy
Alfa Aesar 41385 Chlorhexidine digluconate, 20% w/v aq. soln., non-sterile 18472-51-0 *4x500ml $504 2017-11-08 Buy

Chlorhexidine digluconate Chemical Properties,Uses,Production

Description

Chlorhexidine digluconate solution is a bis(biguanide) family cationic broad spectrum antibiotic that is available in a range of concentrations and has been safely used for over 40 years for a variety of health-related applications; but its specific use for umbilical cord care was uniquely tested in three clinical trials in Nepal, Bangladesh, and Pakistan, in the form of 7.1% chlorhexidine digluconate (CHX). Given the promising results of the trials, in 2013 the World Health Organization (WHO) added CHX to its Model List of Essential Medicines for Children; and in 2014 the WHO issued a new guideline on umbilical cord care, which included a formal recommendation on the use of chlorhexidine.
Chlorhexidine digluconate is a broad spectrum antiseptic. Its mechanism of action involves destabilization of the outer bacterial membrane. It is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria.It has both bactericidal and bacteriostatic mechanisms of action, the mechanism of action being membrane disruption, not ATPase inactivation as previously thought.It is also useful against fungi and enveloped viruses, though this has not been extensively investigated. Chlorhexidine is harmful in high concentrations, but is used safely in low concentrations in many products, such as mouthwash and contact lens solutions.

Uses

Hydrogenolysis of benzyl-nitrogen bonds

Uses

Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.
The gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.
Chlorhexidine digluconate 20% solution is a broad spectrum bacteriostatis antiseptic agent, oral care agent, disinfectant, cosmetic biocide, and preservative. It is very effective against plaque, oral flora including Candida and is active against gram-positive and gram-negative organisms, facultative anaerobes, aerobes, and yeast. It can be used in antiseptic soap, mouthwash that fights plaque, disinfecting wounds and burns, vaginal flushing, hair dyes and bleaches, makeup, and other skin and hair care products.

Chlorhexidine digluconate Preparation Products And Raw materials

Raw materials

Preparation Products


Chlorhexidine digluconate Suppliers

Global( 224)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Bojing Chemical Co.,Ltd.
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021-69106780 bangchem1@163.com China 8323 60
Hubei YiKangYuan Chemical Co., Ltd. 027-87182908 027-87182808 18064088908
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