DIETHYLPHOSPHONOACETIC ACID
- CAS No.
- 3095-95-2
- Chemical Name:
- DIETHYLPHOSPHONOACETIC ACID
- Synonyms
- 2-(diethoxyphosphoryl)acetic acid;NSC 272281;Diethyl sulfonic acid;Venadaparib Impurity 39;acetyl diethyl phosphate;Diethylphosphoacetic acid;(diethoxyphosphoryl)acetate;DIETHYLPHOSPHONOACETIC ACID;2-diethoxyphosphorylacetate;DIETHYLPHOSPHONOETHANOIC ACID
- CBNumber:
- CB9724914
- Molecular Formula:
- C6H13O5P
- Molecular Weight:
- 196.14
- MDL Number:
- MFCD00192032
- MOL File:
- 3095-95-2.mol
- MSDS File:
- SDS
| Boiling point | 150 °C/0.05 mmHg (lit.) |
|---|---|
| Density | 1.220 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Viscous Liquid |
| pka | 3.48±0.10(Predicted) |
| color | Clear colorless to yellow |
| Specific Gravity | 1.220 |
| InChI | InChI=1S/C6H13O5P/c1-3-10-12(9,11-4-2)5-6(7)8/h3-5H2,1-2H3,(H,7,8) |
| InChIKey | DVQMPWOLBFKUMM-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CP(OCC)(OCC)=O |
| FDA UNII | 6L31G8862Z |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 37/39-26 |
| WGK Germany | 3 |
| HS Code | 29319090 |
DIETHYLPHOSPHONOACETIC ACID price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 268127 | Diethylphosphonoacetic acid 95% | 3095-95-2 | 5ml | $18.76 | 2024-03-01 | Buy |
| Sigma-Aldrich | 268127 | Diethylphosphonoacetic acid 95% | 3095-95-2 | 25ml | $143 | 2024-03-01 | Buy |
| TRC | D444745 | Diethylphosphonoacetic acid | 3095-95-2 | 25g | $140 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | ING0004122 | DIETHYLPHOSPHONOACETIC ACID 95.00% | 3095-95-2 | 5ML | $775.24 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | ING0004122 | DIETHYLPHOSPHONOACETIC ACID 95.00% | 3095-95-2 | 25ML | $1112.15 | 2021-12-16 | Buy |
DIETHYLPHOSPHONOACETIC ACID Chemical Properties,Uses,Production
Description
Diethylphosphonoacetic Acid (DPA) is a Horner-Wadsworth-Emmons (HWE) reagent. The mixed anhydride of trifluoroacetic acid—diethylphosphonoacetic acid Treat a 21-hydroxy-20-keto steroid leads directly to cardenolides by an intramolecular Horner-Emmons reaction. It could also used as a dummy template to prepare a molecularly imprinted polymer for use as an artificial receptor for organophosphorus pesticides (OPPs)[1-3].
Chemical Properties
clear colorless to yellow viscous liquid
Uses
Acts as a nucleophile for nucleophilic addition reactions for synthesis of allene epoxides
Reactant for:
- Stereoselectivity studies of the Staudinger reaction
- Enantioselective formation of diols via epoxidation and hydration reactions
- Horner-Wadsworth-Emmons reactions
- Remote chelation controlled Ireland-Claisen rearrangement
- Ugi-Dieckmann reactions for synthesis of tetramic acid derivatives
Uses
Diethylphosphonoacetic Acid is a reagent that is used for enantioselective preparation of α-phosphoryl-α,β-unsatd.-δ-aryl-δ-lactones from nonracemic β-hydroxyaldehydes and their conversion to α-methylene-δ-aryl-δ-lactones.
Synthesis Reference(s)
Journal of the American Chemical Society, 102, p. 4534, 1980 DOI: 10.1021/ja00533a047
References
[1] S. Donovan, J. Mcmurry, M. Avery. “Synthesis of digitoxigenin by remote functionalization.” Tetrahedron Letters 20 1 (1979): 3287–3290.
[2] A. M. Boldi, Hisham O. Eissa, Charles R. Johnson. “Solid-phase library synthesis of triazolopyridazines via [4+2] cycloadditions.” Tetrahedron Letters 40 1 (1999): 619–622.
[3] Lu Zhang. “Preparation and Characterization of Broad-Spectrum Artificial Antibody for OPPs Based on Dummy Template Imprinting Technique.” International Journal of Polymer Analysis and Characterization 117 1 (2014): 510–521.
DIETHYLPHOSPHONOACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1320 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
View Lastest Price from DIETHYLPHOSPHONOACETIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-12-20 | 2-(Diethoxyphosphinyl)acetic acid
3095-95-2
|
US $0.00-0.00 / kg | 1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd | |
 |
2023-08-16 | Diethylphosphonoacetic acid
3095-95-2
|
US $1.00 / KG | 1KG | >99% | 3000T | Weijer International Trade (Hebei) Co., Ltd | |
 |
2022-10-01 | Diethylphosphonoacetic acid
3095-95-2
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 2-(Diethoxyphosphinyl)acetic acid
3095-95-2
- US $0.00-0.00 / kg
- 98%
- Nanjing Fred Technology Co., Ltd
-
- Diethylphosphonoacetic acid
3095-95-2
- US $1.00 / KG
- >99%
- Weijer International Trade (Hebei) Co., Ltd
-
- Diethylphosphonoacetic acid
3095-95-2
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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