Methyl chloroacetate
- CAS No.
- 96-34-4
- Chemical Name:
- Methyl chloroacetate
- Synonyms
- methyl 2-chloroacetate;MONO METHYL CHLORO ACETATE;METHYL MONOCHLOROACETATE;IHT-FC MCA;Chloroacetic acid methyl;CHLOROACETIC ACID METHYL ESTER;ClH2CCOOCH3;AKOS BBS-00004061;Methylechloroacetate;Mathyl Chloroacetate
- CBNumber:
- CB9854725
- Molecular Formula:
- C3H5ClO2
- Molecular Weight:
- 108.52
- MDL Number:
- MFCD00000931
- MOL File:
- 96-34-4.mol
| Melting point | -33 °C |
|---|---|
| Boiling point | 130 °C740 mm Hg(lit.) |
| Density | 1.238 g/mL at 25 °C(lit.) |
| vapor density | 3.8 (vs air) |
| vapor pressure | 10 mm Hg ( 25 °C) |
| refractive index |
n |
| Flash point | 125 °F |
| storage temp. | Store at <= 20°C. |
| solubility | 51.6g/l (slow decomposition) |
| form | Liquid |
| color | Clear colorless |
| PH | 4.6 (28g/l, H2O, 20℃) |
| explosive limit | 4.6-18.5%(V) |
| Water Solubility | 28 g/L (20 ºC) |
| Merck | 14,6042 |
| BRN | 506255 |
| Dielectric constant | 12.9（20℃） |
| LogP | 0.63 at 20℃ |
| CAS DataBase Reference | 96-34-4(CAS DataBase Reference) |
| EWG's Food Scores | 1-3 |
| FDA UNII | 450VSB182I |
| NIST Chemistry Reference | Acetic acid, chloro-, methyl ester(96-34-4) |
| EPA Substance Registry System | Acetic acid, 2-chloro-, methyl ester (96-34-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H301+H331-H315-H318-H335 | |||||||||
| Precautionary statements | P210-P280-P301+P310-P303+P361+P353-P304+P340+P311-P305+P351+P338 | |||||||||
| Hazard Codes | T,Xi,F | |||||||||
| Risk Statements | 10-23/25-37/38-41-40-36/37/38-38 | |||||||||
| Safety Statements | 26-37/39-45-36-16 | |||||||||
| RIDADR | UN 2295 6.1/PG 1 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | AF9500000 | |||||||||
| F | 19 | |||||||||
| Autoignition Temperature | 869 °F | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2915 40 00 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | I | |||||||||
| Toxicity | LD50 orally in Rabbit: 107 mg/kg | |||||||||
| NFPA 704 |
|
Methyl chloroacetate price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.02413 | Methyl chloroacetate for synthesis | 96-34-4 | 100mL | $39 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.02413 | Methyl chloroacetate for synthesis | 96-34-4 | 1L | $84.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 108413 | Methyl chloroacetate 99% | 96-34-4 | 500g | $60.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 108413 | Methyl chloroacetate 99% | 96-34-4 | 1kg | $63 | 2024-03-01 | Buy |
| Alfa Aesar | A10325 | Methyl chloroacetate, 99+% | 96-34-4 | 250g | $20.6 | 2024-03-01 | Buy |
Methyl chloroacetate Chemical Properties,Uses,Production
Chemical Properties
clear colorless liquid with a slight irritating odor. It is miscible with organic solvents such as ethanol, ether, acetone and benzene. Slightly soluble in water.
Uses
Methyl chloroacetate is used as a solvent and chemical intermediate. It acts as a precursor in the preparation of (carboxymethyl) trimethylammonium chloride esters. Further, it is used in the preparation of octakis-(carbethoxymethoxy)calix[8]arene. It is employed as an extraction solvent during the separation of neutral compounds. In addition to this, it is used in the synthesis of dimethyl carbonate.
Application
Methyl chloroacetate (MC) is a halogenated ester mainly used as a solvent in organic synthesis or in the preparation of several compounds. Typically, MC is used in the preparation of (carboxymethyl) trimethylammonium chloride estersor in the synthesis of octakis- (carbethoxymethoxy)calix[8]arene. Additionally, methyl chloroacetate acts as an extraction solvent during the separation of neutral compounds with concentration enhancement using coupling liquid–liquid semi-microextraction with micellar electrokinetic chromatography through oncapillary decomposition.
Preparation
Methyl chloroacetate is prepared by esterification of chloroacetic acid with methanol.
Reaction: Methanol and chloroacetic acid are uniformly mixed in a weight ratio of 0.366:1, heated with stirring, and the esterification reaction is carried out at 105-110 °C. In the reaction process, the ternary azeotrope of methyl chloroacetate, water and methanol is continuously steamed, layered through the ester separator, the separated methanol and water are returned to the reaction pot, and the separated crude ester is made of sodium carbonate. neutralize. The neutralized crude ester is firstly cut out the 130°C fraction by atmospheric distillation, and then subjected to vacuum distillation to collect the 65°C (8kPa) fraction, which is the finished product of methyl chloroacetate. The yield is about 96%.
Synthesis Reference(s)
The Journal of Organic Chemistry, 50, p. 3408, 1985 DOI: 10.1021/jo00218a034
General Description
A crystalline solid or a solid dissolved in a liquid. Insoluble in water and denser than water. Contact may slightly irritate skin, eyes and mucous membranes. May be slightly toxic by ingestion. Used to make other chemicals.
Air & Water Reactions
Highly flammable. Insoluble in water.
Reactivity Profile
Methyl chloroacetate is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Hazard
Toxic by ingestion and inhalation.
Health Hazard
Extremely corrosive to the eyes, skin, nose, throat, and upper respiratory tract. Inhalation may be fatal as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.
Fire Hazard
Special Hazards of Combustion Products: Toxic fumes of hydrogen chloride
Safety Profile
Poison by ingestion. Moderately toxic by inhalation and subcutaneous routes. Flammable when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits toxic fumes of Cl-.
Purification Methods
Shake the ester with saturated aqueous Na2CO3 (three times), aqueous 50% CaCl2 (three times), saturated aqueous NaCl (twice), dry (Na2SO4) and fractionally distil it. Very toxic. [Beilstein 2 IV 480.]
Methyl chloroacetate Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yancheng Green Chemicals Co.,Ltd | +undefined-86-25-86655873 | info@royal-chem.com | China | 114 | 58 |
| Ningxia Jinhua Chemical Co.,Ltd | 025-52279164 | info@nxjhchem.com | China | 79 | 58 |
| Changde Changlian Chemical Co., Ltd. | +86-25-86736270 +86-15905172087 | brian.he@royal-chem.com | China | 103 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9309 | 58 |
| Zouping mingyuan import & export trading co., ltd | +86-0543-2240078 +8618364991597 | myzhao793@163.com | China | 994 | 58 |
| Shandong Dexiang International Trade Co., Ltd | 15662695772;+8615662691337 | sales006@dexiangchemical.com | China | 998 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9352 | 55 |
| Anhui Royal Chemical Co., Ltd. | +86-25-86655873 +8613962173137 | marketing@royal-chem.com | China | 205 | 55 |
View Lastest Price from Methyl chloroacetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-19 | Methyl chloroacetate
96-34-4
|
US $0.00 / Kg/Drum | 1KG | 99% | 2000mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2024-04-19 | Methyl chloroacetate
96-34-4
|
US $0.00 / Kg/Drum | 1000KG | 99% | 10tons | Changde Changlian Chemical Co., Ltd. | |
 |
2024-04-19 | Methyl chloroacetate
96-34-4
|
US $0.00 / Kg/Drum | 1000KG | 99% | 10tons | Gansu Jinyuantai New Material Co., Ltd. |
-
- Methyl chloroacetate
96-34-4
- US $0.00 / Kg/Drum
- 99%
- Jinan Finer Chemical Co., Ltd
-
- Methyl chloroacetate
96-34-4
- US $0.00 / Kg/Drum
- 99%
- Changde Changlian Chemical Co., Ltd.
-
- Methyl chloroacetate
96-34-4
- US $0.00 / Kg/Drum
- 99%
- Gansu Jinyuantai New Material Co., Ltd.
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